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九州大学 生体防御医学研究所
〒812-8582
福岡市東区馬出3-1-1
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研究推進ユニット 【発生工学実験室 ・ 先端研究開発室 ・ 情報解析基盤室】

実績（2000〜）

研究推進ユニットの研究支援サービスや共通機器を利用して行った研究の成果を学会誌等に発表される場合には、論文にその旨ご記載いただくと共に、研究推進ユニットまでご一報下さいますよう、よろしくお願い致します。
2022年9月13日現在、245報の論文を掲載しております。
2022年（3)
  1. Yano S., Ishiuchi T., Abe S., Namekawa S.H., Huang G., Ogawa Y., Sasaki, H. Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes. Nat. Commun. 2022 Aug 3;13:4440. [PubMed]
    （研究推進ユニット 技術支援室/次世代シークエンス解析/エピゲノム制御学分野）
  2. Mise S., Matsumoto A., Shimada K., Hosaka T., Takahashi M., Ichihara K., Shimizu H., Shiraishi C., Saito D., Suyama M., Yasuda T., Ide T., Izumi Y., Bamba T., Kimura-Someya T., Shirouzu M., Miyata H., Ikawa M., Nakayama KI. Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nature Commun. 13, 1071 (2022).[PubMed]
    （研究推進ユニット 技術支援室/分子医科学分野）
  3. Mizuno Y, Abolhassani N, Mazzei G, Saito T, Saido, TC, Yamasaki R, J. Kira, Nakabeppu Y. Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the App[NL-G-F/NL-G-F] knock-in mouse model of Alzheimer's disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior. Neurosci Res. 2022 Apr;177:118-134. [PubMed]
    （研究推進ユニット 発生工学実験室/脳機能制御学分野）
2021年（15)
  1. Nakajima H., Fujita S., Kakae M., Nagayasu K., Oh-hora M., Shirakawa H., Kaneko S. Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α-stimulated astrocytes. Glia. 2022;70:1666–1680. [PubMed]
    （研究推進ユニット 発生工学実験室/京都大学薬学研究科）
  2. Nakashima Y., Gotoh K., Mizuguchi S., Setoyama D., Takata Y., Kanno T., D. Kang . Attenuating Effect of Chlorella Extract on NLRP3 Inflammasome Activation by Mitochondrial Reactive Oxygen Species. Front Nutr. 2021 Oct 8;8:763492. [PubMed]
    （研究推進ユニット 技術支援室/電子顕微鏡観察/九大病院検査部）
  3. Mizuguchi S., Gotoh K., Nakashima Y., Setoyama D., Takata Y., Ohga S., D. Kang. Mitochondrial Reactive Oxygen Species Are Essential for the Development of Psoriatic Inflammation. Front Immunol. 2021 Aug 6;12:714897.[PubMed]
    （研究推進ユニット 技術支援室/電子顕微鏡観察/九大病院検査部）
  4. Nita A., Matsumoto A., Tang R., Shiraishi C., Ichihara K., Saito D., Suyama M., Yasuda T., Tsuji G., Furue M., Katayama B., Ozawa T., Murata T., Dainichi T., Kabashima K., Hatano A., Matsumoto M., Nakayama KI. A ubiquitin-like protein encoded by the “noncoding” RNA TINCR promotes keratinocyte proliferation and wound healing. PLoS Genet. 2021 Aug 5;17(8):e1009686. [PubMed]
    （研究推進ユニット 技術支援室/分子医科学分野、情報生物学分野）
  5. Matsuzaki F., Uda S., Yamauchi Y., Matsumoto M., Soga T., Maehara K., Ohkawa Y., Nakayama KI., Kuroda S., Kubota H. An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver. Cell Rep. 2021 Aug 24;36(8):109569. [PubMed]
    （研究推進ユニット 技術支援室/プロテオーム解析/統合オミクス分野、トランスクリプトミクス分野、分子医科学分野）
  6. Ichihara K., Matsumoto A., Nishida H., Kito Y., Shimizu H., Shichino Y., Iwasaki S., Imami K., Ishihama Y., Nakayama KI.　Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons. Nucleic Acids Res. 2021 Jul 21;49(13):7298-7317. [PubMed]
    （研究推進ユニット 技術支援室/次世代シークエンス解析/分子医科学分野）
  7. Kawamura A., Katayama Y., Kakegawa W., Ino D., Nishiyama M., Yuzaki M., Nakayama KI. The autism-associated protein CHD8 is required for cerebellar development and motor function. Cell Rep. 35: 108932, 2021.[PubMed]
    （研究推進ユニット 技術支援室、発生工学実験室/病理標本作製、発生工学実験室、プロテオーム解析、次世代シークエンス/分子医科学分野）
  8. Nita A., Muto Y., Katayama Y., Matsumoto A., Nishiyama M., Nakayama KI. The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells. Cell Rep. 2021 Feb 2;34(5):108688. [PubMed]
    （研究推進ユニット 技術支援室/次世代シークエンス解析/分子医科学分野）
  9. Ishiuchi T., Abe S., Inoue K., Wan Kin Au Yeung, Miki Y., Ogura A., Sasaki H. Reprogramming of the histone H3.3 landscape in the early mouse embryo. Nat. Struct. Mol. Biol. 2021 Jan;28(1):38-49. [PubMed]
    （研究推進ユニット/エピゲノム制御学分野）
  10. Morikawa T, Ohishi H, Kosaka K, Shimojo T, Nagano A, Taniguchi I, Fujioka R, Moriyama K, Unoki M, Takahashi M, Nakao M, Izumi Y, Bamba T, Sasaki H , Miura S, Shibata H. Ddhd1 knockout mouse as a model for familial spastic paraplegia. Biosci Rep. 41(2): BSR20204171 (2021).[PubMed]
    （研究推進ユニット 技術支援室、発生工学実験室/次世代シークエンス、発生工学実験室/エピゲノム制御学分野）
  11. Yasuda T, Saito Y, Ono C, Kawata K, Baba A, Baba Y. Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells. Sci. Rep. 11, 5524 (2021) [PubMed]
    （研究推進ユニット 発生工学実験室/免疫ゲノム生物学分野）
  12. Hasuwa, H., Iwasaki, Y.W., Au Yeung, W.K., Ishino, K., Masuda, H., Sasaki, H. & Siomi, H. Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters. Nat. Cell Biol. 23, 1002-1012 (2021).[PubMed]
    （研究推進ユニット 技術支援室/次世代シークエンス解析/慶應大学、エピゲノム制御学分野）
  13. Kibe K., Shirane K., Ohishi H., Uemura S., Toh H., Sasaki H. The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes. PLoS Genet. 2021 May 28;17(5):e1009570. [PubMed]
    （研究推進ユニット 技術支援室/次世代シークエンス解析/エピゲノム制御学分野）
  14. Abe S., Nagatomo H., Sasaki H., Ishiuchi T. A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation. Epigenetics. 2021 Oct;16(10):1123-1134. [PubMed]
    （研究推進ユニット/エピゲノム制御学分野）
  15. Mizuno Y., N. Abolhassani, G. Mazzei, Sakumi K., Saito T., C Saido T., Ninomiya T., Iwaki T., Yamasaki R., Kira J., Nakabeppu Y. MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer’s Disease. Oxid Med Cell Longev. 2021 Dec 21;2021:8635088. [PubMed]
    （研究推進ユニット 技術支援室、発生工学実験室/発生工学実験室、マイクロアレイ、次世代シークエンス/脳機能制御学分野）
2020年（13)
  1. Takahashi H., A. Ranjan, S. Chen, Suzuki H., Shibata M., Hirose T., Hirose H., Sasaki K., Abe R., K. Chen, Y. He, Y. Zhang, Takigawa I., Tsukiyama T., Watanabe M., Fujii S., Iida M., Yamamoto J., Yamaguchi Y., Suzuki Y., Matsumoto M., Nakayama KI, M P Washburn, A Saraf, L Florens, Sato S., Tomomori-Sato C., R C Conaway, J W Conaway, Hatakeyama S. The role of Mediator and Little Elongation Complex in transcription termination. Nat Commun. 2020 Feb 26;11(1):1063.[PubMed]
    （研究推進ユニット 技術支援室/プロテオーム解析/横浜市立大学（共同利用共同研究拠点）、分子医科学分野）
  2. Kawamura A., Abe Y., Seki F., Katayama Y., Nishiyama M., Takata N., Tanaka F K., Okano H., Nakayama KI. Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain. Mol Brain. 2020 Nov 23;13(1):160.[PubMed]
    （研究推進ユニット 発生工学実験室/分子医科学分野）
  3. Miura S., and Suzuki A. Induction of Steatohepatitis and Liver Tumorigenesis by Enforced Snail Expression in Hepatocytes. Am. J. Pathol. 190, 1271-1283.[PubMed]
    （研究推進ユニット 技術支援室/病理標本作製、電子顕微鏡観察、DNAシークエンス/器官発生再生学分野）
  4. Yamauchi Y., Nita A., Nishiyama M., Muto Y., Shimizu H., Nakatsumi H., Nakayama KI. Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development. Genes Cells. 2020 Jun;25(6):427-438.[PubMed]
    （研究推進ユニット 技術支援室/病理標本作製/分子医科学分野）
  5. Horisawa K., Udono M., Ueno K., Ohkawa Y., Nagasaki M., Sekiya S., Suzuki A. The dynamics of transcriptional activation by hepatic reprogramming factors. Mol Cell 79, 660-676.[PubMed]
    （研究推進ユニット 技術支援室/プロテオーム解析/器官発生再生学分野、トランスクリプトミクス分野）
  6. Kito Y., Matsumoto M., Hatano A., Takami T., Oshikawa K., Matsumoto A., Nakayama KI. Cell cycle-dependent localization of the proteasome to chromatin. Sci. Rep. 2020 Apr 2;10(1):5801.[PubMed]
    （研究推進ユニット 技術支援室/プロテオーム解析/分子医科学分野）
  7. Julien Richard Albert, Wan Kin Au Yeung, Keisuke Toriyama, Hisato Kobayashi, Ryutaro Hirasawa, Julie Brind'Amour, Aaron Bogutz, Hiroyuki Sasaki, Matthew Lorincz. Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo. Nat Commun. 2020 Oct 27;11(1):5417.[PubMed]
    （研究推進ユニット 技術支援室/大規模DNAシークエンス/エピゲノム制御学分野）
  8. Ohishi H., Wan Kin Au Yeung, Unoki M., Ichiyanagi K., Fukuda K., Maenohara S., Shirane K., Chiba H., Sado T., and Sasaki H. Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells. Genes Cells2020 Jan;25(1):54-64.[PubMed]
    （研究推進ユニット 技術支援室/大規模DNAシークエンス/エピゲノム制御学分野）
  9. Onoyama I., Nakayama S., Shimizu H. Nakayama KI. Loss of Fbxw7 impairs development of and induces heterogeneous tumor formation in the mouse mammary gland. Cancer Res. 2020 Dec 15;80(24):5515-5530.[PubMed]
    （研究推進ユニット 技術支援室、発生工学実験室/発生工学実験室、大規模DNAシークエンス/分子医科学分野）
  10. Mayanagi K., Oki K., Miyazaki N., Ishino S., Yamagami T., Morikawa K., Iwasaki K., Kohda D., Shirai T., Ishino Y. Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy. BMC Biology 18, 152 (2020).[PubMed]
    （研究推進ユニット 技術支援室/電子顕微鏡観察/構造生物学分野、九大農学研究院）
  11. Inada H., Udono M., Matsuda-Ito K., Horisawa K., Ohkawa Y., Miura S., Goya T., Yamamoto J., Nagasaki M., Ueno K., Saitou D., Suyama M., Maehara Y., Kumamaru W., Ogawa Y., Sekiya S., Suzuki A. Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells. Nat Commun.11, 5292 (2020).[PubMed]
    （研究推進ユニット 技術支援室/病理標本作製、電子顕微鏡観察、DNAシークエンス/器官発生再生学分野、トランスクリプトミクス分野、情報生物学分野）
  12. Koga Y., Tsuchimoto D., Hayashi Y., N. Abolhassani, Yoneshima Y., Sakumi K., Nakanishi H., Toyokuni S., Nakabeppu Y. Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy. JCI Insight . 2020 Nov 19;5(22):140229.[PubMed]
    （研究推進ユニット 技術支援室、発生工学実験室/発生工学実験室、DNAシークエンス、病理標本作製/脳機能制御学分野）
  13. Iwamori T., Iwamori N., Matsumoto M., Imai H., Ono E. Novel Localizations and Interactions of Intercellular Bridge Proteins Revealed by Proteomic Profiling. Biol. Reprod. 2020 Apr 24;102(5):1134-1144.[PubMed]
    （研究推進ユニット 技術支援室/プロテオーム解析、病理標本作製/医・実験動物）
2019年（11)
  1. Yamauchi S, Mano S, Oikawa K, Hikino K, Teshima KM, Kimori Y, Nishimura M, Shimazaki K, Takemiya A. Autophagy controls reactive oxygen species homeostasis in guard cells that is essential for stomatal opening. Proc Natl Acad Sci USA 116: 19187-19192 (2019).[PubMed]
    （研究推進ユニット 技術支援室/プロテオーム解析/山口大学大学院創成科学研究科（共同利用共同研究拠点））
  2. Takii R., Fujimoto M., Matsumoto M., P. Srivastava, A. Katiyar, Nakayama KI.,Nakai A. The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment. EMBO J.2019 Dec 16;38(24).[PubMed]
    （研究推進ユニット 技術支援室/プロテオーム解析/山口大学大学院医学系研究科医化学講座（共同利用共同研究拠点））
  3. Aktar S, Sasaki H, Unoki M. Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation. Genes Cells. 2019 Nov 13;24(11):746-755.[PubMed]
    （研究推進ユニット 技術支援室/DNAシークエンス/エピゲノム制御学）
  4. Terada M., Kawamata M., Kimura R., Sekiya S., Nagamatsu G., Hayashi K., Horisawa K., Suzuki A. Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells. Genesis. 2019 Nov;57(11-12):e23334.[PubMed]
    （研究推進ユニット 技術支援室、発生工学実験室/発生工学実験室、病理標本作製/器官発生再生学分野）
  5. Hanawa-Suetsugu K, Itoh Y, Ab Fatah M, Nishimura T, Takemura K, Takeshita K, Kubota S, Miyazaki N, Wan Mohamad Noor WNI, Inaba T, Nguyen NTH, Hamada-Nakahara S, Oono-Yakura K, Tachikawa M, Iwasaki K, Kohda D, Yamamoto M, Kitao A, Shimada A, Suetsugu S. Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7. Nat Commun. 2019 Oct 18;10(1):4763.[PubMed]
    （研究推進ユニット 技術支援室/電子顕微鏡観察/奈良先端科学技術大学院大学）
  6. Inoguchi Y., Ichiyanagi K., Ohishi H., Maeda Y., Sonoda N., Ogawa Y., Inoguchi T., Sasaki H. Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring. Sci Rep. 2019 Jul 15;9(1):10181.[PubMed]
    （研究推進ユニット 技術支援室/大規模DNAシークエンス解析/エピゲノム制御学分野）
  7. Ishiuchi T., Ohishi H., Sato T., Kamimura S., Yorino M., Abe S., Suzuki A., Wakayama T., Suyama M., Sasaki H. Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development. Cell Rep. 2019 May 7;27(6):1742-1754.[PubMed]
    （研究推進ユニット 技術支援室/エピゲノム制御学分野）
  8. Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI. Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. J Exp Med. 2019 Apr 1;216(4):950-965.[PubMed]
    （研究推進ユニット 技術支援室/マイクロアレイ解析/分子医科学分野）
  9. Shimizu H, Takeishi S, Nakatsumi H, Nakayama KI. Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells. JCI Insight. 2019 Feb 21; 4(4): e125138.[PubMed]
    （研究推進ユニット 技術支援室/LSM/分子医科学分野）
  10. Unoki M, Funabiki H, Velasco G, Francastel C, Sasaki H. CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome. J Clin Invest. 2019 Jan 2;129(1):78-92.[PubMed]
    （研究推進ユニット 技術支援室/プロテオーム解析/エピゲノム制御学分野）
  11. Haruki R, Kouno H, Hosoyamada M, Ogawa T, Yanai N, Kimizuka N.　Oligo(ethylene glycol)/alkyl-modified Chromophore Assemblies for Photon Upconversion in Water.　Chem Asian J. 2019 Jan 2.[PubMed]
    （研究推進ユニット 技術支援室/電子顕微鏡観察/九大工学部応用化学）
2018年（7)
  1. Abe Y., Honsho M., Itoh R., Kawaguchi R., Fujitani M., Fujiwara K., Hirokane M., Matsuzaki T., Nakayama K., Ohgi R., Marutani T., Nakayama KI, Yamashita T., Fujiki Y. Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum.　Life Sci Alliance. 2018 Dec 3;1(6):e201800062.[PubMed]
    （研究推進ユニット 技術支援室/オルガネラホメオスタシス分野）
  2. Imai T., Matsumura T., S. Mayer-Lambertz, C. A. Wells, Ishikawa E., S. K. Butcher, T. C. Barnett, M. J. Walker, Imamura A., Ishida H., Ikebe T., Miyamoto T., Ato M., Ohga S., B. Lepenies, N. M. van Sorge, Yamasaki S. Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10662-E10671.[PubMed]
    （研究推進ユニット 技術支援室、発生工学実験室/病理標本作製、発生工学実験室/大阪大学微生物病研究所分子免疫制御分野）
  3. Gotoh K, Morisaki T, Setoyama D, Sasaki K, Yagi M, Igami K, Mizuguchi S, Uchiumi T, Fukui Y, Kang D. Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation. Cell Rep. 2018 Nov 13;25(7):1800-1815.e4.[PubMed]
    （研究推進ユニット 技術支援室/電子顕微鏡観察/九大医学部臨床検査医学分野）
  4. Sakakibara Y., Nagao K., Blewitt M., Sasaki H., Obuse C., Sado T. Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice. Development. 2018 Sep 25;145(18).[PubMed]
    （研究推進ユニット 技術支援室/大規模DNAシークエンス解析/エピゲノム制御学分野）
  5. Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. Ann Neurol. 2018 Aug;84(2):208-224.[PubMed]
    （研究推進ユニット 技術支援室/プロテオーム解析/九大医学部神経内科、脳機能制御学分野）
  6. Nakayama S, Yumimoto K, Kawamura A, Nakayama KI. Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3. J Biol Chem. 2018 Apr 13;293(15):5705-5714.[PubMed]
    （研究推進ユニット 技術支援室/分子医科学分野）
  7. Koshiyama T, Tanaka M, Honjo M, Fukunaga Y, Okamura T, Ohba M. Direct Synthesis of Prussian Blue Nanoparticles in Liposomes Incorporating Natural Ion Channels for Cs+ Adsorption and Particle Size Control.Langmuir. 2018 Jan 30;34(4):1666-1672.[PubMed]
    （研究推進ユニット 技術支援室/電子顕微鏡観察/九大理学部無機・分析化学講座）
2017年（19)
  1. Muto Y., Nishiyama M., Nita A., Moroishi T. Nakayama KI.　Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.　Nature Commun.8: 16114, 2017.[PubMed]
    （技術室/マイクロアレイ解析/分子医科学分野）
  2. Yaguchi H., Yabe I., Takahashi H., Watanabe M., Nomura T., Kano T., Matsumoto M., Nakayama KI., Watanabe M., Hatakeyama S. Sez6l2 regulates phosphorylation of ADD and neuritogenesis. Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):234-241.[PubMed]
    （技術室/プロテオーム解析/北海道大学医化学（共同利用共同研究拠点））
  3. Nakatsumi H., Matsumoto M., Nakayama KI. Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages. Cell Rep. 2017 Nov 28;21(9):2471-2486.[PubMed]
    （技術室/プロテオーム解析、DNAシークエンス、マイクロアレイ/分子医科学分野）
  4. Fujinami D., Taguchi Y., Kohda D. Asn-linked oligosaccharide chain of a crenarchaeon, Pyrobaculum calidifontis, is reminiscent of the eukaryotic high-mannose-type glycan. Glycobiology. 2017 May 16.[PubMed]
    （技術室/プロテオーム解析/構造生物学分野）
  5. Miura S., Suzuki A. Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming. Cell Stem Cell. 2017 Oct 5;21(4):456-471.e5.[PubMed]
    （技術室/病理標本作製/器官発生再生学分野）
  6. Yamazaki S, Tanaka Y, Araki H, Kohda A, Sanematsu F, Arasaki T, Duan X, Miura F, Katagiri T, Shindo R, NakanoH, Ito T, Fukui Y, Endo S, Sumimoto H. The AP-1 transcription factor JunB is required for Th17 cell differentiation. Sci Rep. 2017 Dec 12;7(1):17402.[PubMed]
    （技術室/医学部生化学）
  7. Yanagihara T., Tomino T., Uruno T., Fukui Y. Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes. Biochem Biophys Res Commun. 2017 Jul 15;489(1):8-13.[PubMed]
    （技術室/免疫遺伝学分野）
  8. Fujii T., YamasakiR., Iinuma K., Tsuchimoto D., Hayashi Y., Saitoh B., Matsushita T., Kido M. A., Aishima S., Nakanishi H., Nakabeppu Y., Kira JI. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. Ann Neurol. 2018 Aug;84(2):208-224.[PubMed]
    （技術室/プロテオーム解析/九大病院神経内科、脳機能制御学分野）
  9. E. Castillo, J. Leon, G. Mazzei, N. Abolhassani, Haruyama N., Saito T., Saido T., Hokama M., Iwaki T., Ohara T., Ninomiya T., Kiyohara Y., Sakumi K., F. M. LaFerla, Nakabeppu Y. Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Scientific Reportsvolume 7, Article number: 17762 (2017)[PubMed]
    （技術室/マイクロアレイ/脳機能制御学分野）
  10. Shibata T, Hadano J, Kawasaki D, Dong X, Kawabata SI. Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations. J. Biol. Chem. 2017 Jun 23;292(25):10723-10734.[PubMed]
    （技術室/電子顕微鏡観察/九大理学部生体高分子学研究室）
  11. Kabayama Y, Toh H, Katanaya A, Sakurai T, Chuma S, Kuramochi-Miyagawa S, Saga Y, Nakano T, Sasaki H. Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes. Nucleic Acids Res. 2017 May 19;45(9):5387-5398.[PubMed]
    （技術室、発生工学実験室/大規模DNAシークエンス、発生工学実験室/エピゲノム制御学分野、エピゲノミクス分野）
  12. Matsumoto S, Taguchi Y, Shimada A, Igura M, Kohda D. Tethering an N-Glycosylation Sequon-Containing Peptide Creates a Catalytically Competent Oligosaccharyltransferase Complex. Biochemistry. 2017 Jan 31;56(4):602-611.[PubMed]
    （技術室/DNAシークエンス/構造生物学分野）
  13. Nagata M, Izumi Y, Ishikawa E, Kiyotake R, Doi R, Iwai S, Omahdi Z, Yamaji T, Miyamoto T, Bamba T, Yamasaki S. Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3285-E3294.[PubMed]
    （発生工学実験室/分子免疫学分野、メタボロミクス分野）
  14. Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama KI. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017 Mar 31;37(8).[PubMed]
    （技術室/DNAシークエンス、病理標本作製/分子医科学分野）
  15. Matsumoto M, Matsuzaki F, Oshikawa K, Goshima N, Mori M, Kawamura Y, Ogawa K, Fukuda E, Nakatsumi H, Natsume T, Fukui K, Horimoto K, Nagashima T, Funayama R, Nakayama K, Nakayama KI. A large-scale targeted proteomics assay resource based on an in vitro human proteome. Nat Methods. 2017 Mar;14(3):251-258.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/分子医科学分野、プロテオミクス分野）
  16. Matsumoto S, Taguchi Y, Shimada A, Igura M, Kohda D. Tethering an N-Glycosylation Sequon-Containing Peptide Creates a Catalytically Competent Oligosaccharyltransferase Complex. Biochemistry. 2017 Jan 31;56(4):602-611.[PubMed]
    （技術室/DNAシークエンス/構造生物学分野）
  17. Ohnishi T, Shirane M, Nakayama KI. SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth. Sci Rep. 2017 Jan 20;7:41130.[PubMed]
    （技術室/DNAシークエンス/分子医科学分野）
  18. Mori D, Shibata K, Yamasaki S. C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein β-Glucuronidase on Dendritic Cells. PLoS One. 2017 Jan 3;12(1):e0169562.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、プロテオーム解析、DNAシークエンス/分子免疫学分野）
  19. Nakaya M, Watari K, Tajima M, Nakaya T, Matsuda S, Ohara H, Nishihara H, Yamaguchi H, Hashimoto A, Nishida M, Nagasaka A, Horii Y, Ono H, Iribe G, Inoue R, Tsuda M, Inoue K, Tanaka A, Kuroda M, Nagata S, Kurose H. Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction. J Clin Invest. 2017 Jan 3;127(1):383-401.[PubMed]
    （技術室/電子顕微鏡観察、病理標本作製/九大薬学部薬効安全性学分野）
2016年（15)
  1. Kanemura, S., Okumura, M., Yutani, K., Ramming, T., Hikima, T., Appenzeller-Herzog, C., Akiyama, S., and Inaba, K. Human ER Oxidereductin-1a (Ero1a) undergoes dual regulation through complementary redox interactions with Protein Disulfide Isomerase. J. Biol. Chem. 2016 Nov 11;291(46):23952-23964.[PubMed]
    （技術室/プロテオーム解析/東北大学多元物質科学研究所（共同利用共同研究拠点））
  2. Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Matsuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S. C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection.Immunity. 2016 Dec 20;45(6):1245-1257.[PubMed]
    （発生工学実験室/分子免疫学分野、感染制御学分野）
  3. Sekiya S, Miura S, Matsuda-Ito K, Suzuki A. Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment. Stem Cell Reports. 2016 Dec 13;7(6):1130-1139.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、病理標本作製/器官発生再生学分野）
  4. Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S. The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. J Mol Cell Cardiol. 2016 Nov;100:43-53.[PubMed]
    （技術室/プロテオミクスセンター/北海道大学（共同利用共同研究拠点）、分子医科学分野）
  5. Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y. Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease. Sci Rep. 2016 Nov 29;6:37889.[PubMed]
    （技術室/マイクロアレイ/脳機能制御学分野）
  6. Terada M, Horisawa K, Miura S, Takashima Y, Ohkawa Y, Sekiya S, Matsuda-Ito K, Suzuki A. Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma. Sci Rep. 2016 Oct 4;6:34691.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、病理標本作製/器官発生再生学分野）
  7. Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama KI. CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Nature. 2016 Sep 29;537(7622):675-679.[PubMed]
    （発生工学実験室/分子医科学分野、トランスクリプトミクス分野、情報生物学分野）
  8. Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S. Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat Commun. 2016 Sep 27;7:12756.[PubMed]
    （技術室/マススペクトル測定/分子免疫学分野）
  9. Li Y, Kobayashi K, Mona MM, Satomi C, Okano S, Inoue H, Tani K, Takahashi A. Immunogenic FEAT protein circulates in the bloodstream of cancer patients. J. Transl. Med. 2016 Sep 22;14(1):275.[PubMed]
    （技術室/電子顕微鏡観察/防御分子構築学分野）
  10. Yoneshima Y, Abolhassani N, Iyama T, Sakumi K, Shiomi N, Mori M, Shiomi T, Noda T, Tsuchimoto D, Nakabeppu Y. Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells. Sci Rep. 2016 Sep 13;6:32849.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、DNAシークエンス、病理標本作製/脳機能制御学分野）
  11. Nii T, Kohara H, Marumoto T, Sakuma T, Yamamoto T, Tani K. Single-Cell-State Culture of Human Pluripotent Stem Cells Increases Transfection Efficiency. Biores Open Access. 2016 May 1;5(1):127-36.[PubMed]
    （技術室/防御分子構築学分野）
  12. Hosokawa H, Tanaka T, Endo Y, Kato M, Shinoda K, Suzuki A, Motohashi S, Matsumoto M, Nakayama KI, Nakayama T. Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat Commun. 2016 Apr 7;7:11289.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定、DNAシークエンス/千葉大学（共同利用共同研究拠点）、分子医科学分野）
  13. Tanaka M, Shiota M, Nakao T, Uemura R, Nishi S, Ohkawa Y, Matsumoto M, Yamaguchi M, Osada-Oka M, Inagaki A, Takahashi K, Nakayama KI, Gi M, Izumi Y, Miura K, Iwao H. Identification of low-abundance proteins in serum via the isolation of HSP72 complexes. J. Proteomics. 2016 Mar 16;136:214-21.[PubMed]
    （技術室/プロテオーム解析/大阪市立大学（共同利用共同研究拠点）、分子医科学分野、医学部先端医療医学部門）
  14. Shinoda K, Sun X, Oyamada A, Yamada H, Kira J, Yoshikai Y. Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2016 Feb 15;291:39-45.[PubMed]
    （技術室/病理標本作製/感染制御学分野）
  15. Fujimoto N, Kan-O M, Ushijima T, Kage Y, Tominaga R, Sumimoto H, Takeya R. Transgenic Expression of the Formin Protein Fhod3 Selectively in the Embryonic Heart: Role of Actin-Binding Activity of Fhod3 and Its Sarcomeric Localization during Myofibrillogenesis. PLoS. One. 2016 Feb 5;11(2):e0148472.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、病理標本作製/九大医学部生化学分野）
2015年（13)
  1. Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Yoshinori F. Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus. Nat Commun. 2015 Nov 4;6:8820.[PubMed]
    （技術室/病理標本作製、プロテオーム解析/免疫遺伝学分野、情報生物学分野）
  2. Nishiyama M, Nita A, Yumimoto K, Nakayama KI. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Stem Cells. 2015 Nov;33(11):3327-40.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、プロテオーム解析、病理標本作製/分子医科学分野）
  3. Kiyotake R, Oh-Hora M, Ishikawa E, Miyamoto T, Ishibashi T, Yamasaki S. Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses. J Biol Chem. 2015 Oct 16;290(42):25322-32.[PubMed]
    （技術室/DNAシークエンス、マイクロアレイ解析/分子免疫学分野）
  4. Watanabe K, Yumimoto K, Nakayama KI. FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1. Genes Cells. 2015 Aug;20(8):667-74.[PubMed]
    （技術室/プロテオーム解析/分子医科学分野）
  5. Kazumitsu Maehara, Akihito Harada, Yuko Sato, Masaki Matsumoto, Keiichi I. Nakayama, Hiroshi Kimura, and Yasuyuki Ohkawa. Tissue-specific expression of histone H3 variants diversified after species separation. Epigenetics Chromatin. 2015; 8: 35.[PubMed]
    （技術室/プロテオーム解析/九大医学部先端医療医学部門、分子医科）
  6. Miyake Y, Masatsugu OH, Yamasaki S. C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation. J Immunol. 2015 Jun 1;194(11):5366-74.[PubMed]
    （技術室/DNAシークエンス/分子免疫学分野）
  7. Motomura Y, Kanno S, Asano K, Tanaka M, Hasegawa Y, Katagiri H, Saito T, Hara H, Nishio H, Hara T, Yamasaki S. Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1423-33.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、電子顕微鏡観察、マイクロアレイ解析/分子免疫学分野）
  8. Murata M, Piao JS, Narahara S, Kawano T, Hamano N, Kang JH, Asai D, Ugawa R, Hashizume M. Expression and characterization of myristoylated preS1-conjugated nanocages for targeted cell delivery. Protein Expr Purif. 2015 Jun;110:52-6.[PubMed]
    （技術室/電子顕微鏡観察/九大医学部災害救急医学）
  9. Hosokawa H, Kato M, Tohyama H, Tamaki Y, Endo Y, Kimura M.Y, Tumes D.J, Motohashi S, Matsumoto M, Nakayama K.I, Tanaka T, Nakayama T. Methylation of Gata3 Protein at Arg-261 Regulates Transactivation of the Il5 Gene in T Helper 2 Cells. J Biol Chem. 2015 May 22; 290(21): 13095-13103.[PubMed]
    （技術室/プロテオーム解析、DNAシークエンス/千葉大学(共同利用共同研究拠点)、分子医科学分野）
  10. Yoshida Y, Niwa H, Honsho M, Itoyama A, Fujiki Y. Pex11mediates peroxisomal proliferation by promoting deformation of the lipid membrane. Biol Open. 2015 Apr 24;4(6):710-21.[PubMed]
    （技術室/電子顕微鏡観察/九大理学部生物学科）
  11. Shinoda K, Sun X, Oyamada A, Yamada H, Muta H, Podack ER, Kira J, Yoshikai Y. CD30 ligand is a new therapeutic target for central nervous system autoimmunity. J Autoimmun. 2015 Feb;57:14-23.[PubMed]
    （技術室/病理標本作製/感染制御学分野）
  12. Kobayakawa Y, Sakumi K, Kajitani K, Kadoya T, Horie H, Kira JI, Nakabeppu Y. Galectin-1 deficiency improves axonal swelling of motor neurons in SOD1G93A transgenic mice. Neuropathol Appl Neurobiol. 2015 Feb;41(2):227-44.[PubMed]
    （技術室/電子顕微鏡観察、病理標本作製/脳機能制御学分野）
  13. Yumimoto K, Akiyoshi S, Ueo H, Sagara Y, Onoyama I, Ueo H, Ohno S, Mori M, Mimori K, Nakayama KI.　F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.　J Clin Invest. 2015 Feb;125(2):621-35.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、病理標本作製/分子医科学分野）
2014年（12)
  1. Hokama M., Oka S., J. Leon, Ninomiya T., Honda H., Sasaki K., Iwaki T., Ohara T., Sasaki T., F. M. LaFerla, Kiyohara Y., Nakabeppu Y. Altered expression of diabetes-related genes in Alzheimer’s disease brains: The Hisayama study. Cereb Cortex 24(9):2476-88.2014.[PubMed]
    （技術室/マイクロアレイ/脳機能制御学分野）
  2. Toyonaga K, Miyake Y2, Yamasaki S2. Characterization of the receptors for mycobacterial cord factor in Guinea pig. PLoS One. 9(2):e88747. 2014.[PubMed]
    （技術室/DNAシークエンス/分子免疫学分野）
  3. Moroishi T, Yamauchi T, Nishiyama M, Nakayama KI. HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism. J Biol Chem. 289(23):16430-41. 2014.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/分子医科学分野）
  4. Nomaru H, Sakumi K, Katogi A, Ohnishi YN, Kajitani K, Tsuchimoto D, Nestler EJ, Nakabeppu Y. Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. Glia. 62(8):1284-98.2014.[PubMed]
    （技術室/マイクロアレイ、DNAシークエンス/脳機能制御学分野）
  5. Matsumoto A, Takeishi S, Nakayama KI. p57 regulates T cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling. Blood. 123(22):3429-39. 2014.[PubMed]
    （発生工学実験室/分子医科学分野）
  6. Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, Sanematsu F, Yamamura K, Terasawa M, Nishikimi A, Jean-François Côté, Fukui Y. DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation. J. Exp. Med. 211(7):1407-19.2014.[PubMed]
    （技術室、発生工学実験室/病理組織標本作製、発生工学実験室/免疫遺伝学分野）
  7. Shinoda K, Sun X, Oyamada A, Yamada H, Muta H, Podack ER, Kira JI, Yoshikai Y. CD30 ligand is a new therapeutic target for central nervous system autoimmunity. J Autoimmun. 2014 Dec 18. pii: S0896-8411(14)00169-3.[PubMed]
    （技術室/病理標本作製/感染制御学分野）
  8. Yamauchi T, Nishiyama M, Moroishi T, Yumimoto K, Nakayama KI. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. Mol Cell Biol. 34(17):3321-40. 2014.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/分子医科学分野）
  9. Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T. Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Cell Rep. 8(5):1391-404. 2014.[PubMed]
    （技術室/細胞統御システム分野）
  10. Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.　Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria. Immunity. 41(3):402-13. 2014.[PubMed]
    （技術室/分子免疫学分野）
  11. Sekiya S. and Suzuki A. Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver. Am J Pathol. 184(5):1468-78. 2014.[PubMed]
    （発生工学実験室/器官発生再生学分野）
  12. Yamaguchi S, Marumoto T, Nii T, Kawano H, Liao J, Nagai Y, Okada M, Takahashi A, Inoue H, Sasaki E, Fujii H, Okano S, Ebise H, Sato T, Suyama M, Okano H, Miura Y, Tani K. Characterization of common marmoset dysgerminoma-like tumor induced by the lentiviral expression of reprogramming factors. Cancer Sci. 105(4):402-8. 2014.[PubMed]
    （技術室/病理標本作製/ゲノム病態学分野、情報生物学分野）
2013年（10)
  1. Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, Saito T, Okawa Y, Shibata N, Miyamoto T, Yamasaki S. Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic Fungus Malassezia. Cell Host Microbe. 2013 Apr 17;13(4):477-88.[PubMed]
    （技術室/共同利用共同研究拠点/分子免疫学分野）
  2. Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Naoki Takeda, Chika Sakamoto, Hirotaka Kawano, Takenobu Nii, Shohei Miyamato, Yoko Nagai, Michiyo Okada, Hiroyuki Inoue, Kohichi Kawahara, Akira Suzuki, Yoshie Miura, and Kenzaburo Tani.　Inhibition of PTEN Tumor Suppressor Promotes the Generation of Induced Pluripotent Stem Cells. Mol Ther. 2013 Jun; 21(6): 1242-1250.[PubMed]
    （発生工学実験室/ゲノム病態学分野、ゲノム腫瘍学分野）
  3. Saita S.,Shirane M., Nakayama K.(2013) Selective escape of proteins from the mitochondria during mitophagy. Nat. Commun. 4(1410): 1-14.[PubMed]
    （技術室/電子顕微鏡観察/分子医科学分野）
  4. Yumimoto K., Matsumoto M., Onoyama I., Imaizumi K., Nakayama KI.(2013) F-box and WD repeat domain containing-7 (Fbxw7) targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. J. Biol. Chem.288: 28488-502.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/分子医科学分野）
  5. Matsumoto S., Shimada A., Kohda D. (2013) Crystal structure of the C-terminal globular domain of the third paralog of the Archaeoglobus fulgidus oligosaccharyltransferases.BMC Struct. Biol.13:11.[PubMed]
    （技術室/DNAシークエンス/構造生物学分野）
  6. Matsumoto S., Shimada A., J. Nyirenda, Igura M., Kawano Y., Kohda D. (2013) Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation.PNAS110(44): 17868-17873.[PubMed]
    （技術室/DNAシークエンス/構造生物学分野）
  7. Kamakura S, Nomura M, Hayase J, Iwakiri Y, Nishikimi A, Takayanagi R, Fukui Y, Sumimoto H. The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway. Dev Cell. 26(3):292-302.2013.[PubMed]
    （技術室/九大医学部生化学分野）
  8. Miyake Y, Toyonaga K, Mori D, Kakuta S, Hoshino Y, Oyamada A, Yamada H, Ono K, Suyama M, Iwakura Y, Yoshikai Y, Yamasaki S. C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity. 38(5):1050-62.2013.[PubMed]
    （技術室/分子免疫学分野、感染制御学分野、情報生物学分野）
  9. Yamamoto A, Takeya R, Matsumoto M, Nakayama KI, Sumimoto H. Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1. FEBS J. 280(20):5145-59. 2013.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/九大医学部生化学分野、分子医科学分野）
  10. Ishibashi M, Kogo R, Shibata K, Ueo H, Uchi R, Matsumura T, Takano Y, Sawada G, Takahashi Y, Mima K, Kurashige J, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Suzuki A, Wakabayashi G, Mori M, Mimori K. Clinical significance of PICT1 in patients of hepatocellular carcinoma with wild-type TP53. Ann Surg Oncol. 20 Suppl 3:S537-44. 2013.[PubMed]
    （技術室/DNAシークエンス/九大別府病院外科）
2012年（12)
  1. Sekiya S, Suzuki A. Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J Clin Invest. 2012 Nov 1;122(11):3914-8.[PubMed]
    （発生工学実験室/器官発生再生学分野）
  2. Tateishi Y, Matsumoto A, Kanie T, Hara E, Nakayama K, Nakayama KI. Development of mice without Cip/Kip CDK inhibitors. Biochem Biophys Res Commun. 2012 Oct 19;427(2):285-92.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、病理標本作製/分子医科学分野）
  3. Z. Sheng, Oka S., Tsuchimoto D., N. Abolhassani, Nomaru H., Sakumi K., Yamada H., Nakabeppu Y.(2012) 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA bese excision repair.J. Clin. Invest. 122(12): 4344-4361.[PubMed]
    （技術室/電子顕微鏡観察/脳機能制御学分野）
  4. Kan-o M., Takeya R., Abe T., Kitajima N., Nishida M., Tominaga R., Kurose H., Sumimoto H.(2012) Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis. Biology Open 1: 889-896.[PubMed]
    （技術室/病理標本作製、電子顕微鏡観察/医学部生化学分野）
  5. Ota S., Ishitani S., Shimizu N., Matsumoto K., Itoh M., Ishitani T.(2012) NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J. 31(8): 1904-1915.[PubMed]
    （技術室/病理標本作製/細胞統御システム）
  6. Yumimoto K., Matsumoto M., Oyamada K., Moroishi T., and Nakayama KI. (2012) Comprehensive Identification of Substrates for F-box Proteins by Differential Proteomics Analysis. J. Proteome Res. 11: 3175-3185.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/分子医科学分野）
  7. Oshikawa K., Matsumoto M., Oyamada K., Nakayama KI. (2012) Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. J. Proteome Res. 11: 796-807.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/分子医科学分野）
  8. D. Murata, K. H. Nomura, K. Dejima, S. Mizuguchi, N. Kawasaki, Y. Matsuishi-Nakajima, S. Ito, K. Gengyo-ando, E. Kage-nakadai, S. Mitani, and K. Nomura(2012) GPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans. Mol. Biol. Cell 23(6): 982-995.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/九大理学部発生生物学）
  9. Iwashita Y., Fukuchi N., Waki M., Hayashi K., and Tahira T.(2012) Genome-wide Repression of NF-κB Target Genes by Transcription Factor MIBP1 and Its Modulation by O-Linked β-N-Acetylglucosamine(O-GlcNAc) Transferase.J. Biol. Chem. 287(13): 9887-9900.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定、マイクロアレイ/ゲノム構造学分野）
  10. Shimizu N, Kawakami K, Ishitani T. Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish. Dev Biol. 370(1):71-85.2012.[PubMed]
    （技術室/細胞統御システム分野）
  11. Matsumoto S, Igura M, Nyirenda J, Matsumoto M, Yuzawa S, Noda N, Inagaki F, Kohda D. Crystal structure of the C-terminal globular domain of oligosaccharyltransferase from Archaeoglobus fulgidus at 1.75 Å resolution. Biochemistry. 51(20):4157-66. 2012.[PubMed]
    （技術室/DNAシークエンス/構造生物学分野）
  12. Kan-o M, Takeya R, Taniguchi K, Tanoue Y, Tominaga R, Sumimoto H. Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart. PLoS One. 7(4):e34765.2012.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、電子顕微鏡観察/九大医学部生化学分野）
2011年（11)
  1. Matsuzaki F., Shirane M., Matsumoto M., and Nakayama K.(2011) Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.Mol. Biol. Cell 22: 4602-4620.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定、DNAシークエンス、Deltavision/分子医科学分野）
  2. Moroishi T., Nishiyama M., Takeda Y., Iwai K., Nakayama K.(2011) The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo.Cell Metab. 14: 339-351.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定、病理標本作製、電子顕微鏡観察/分子医科学分野）
  3. Iwama E., Tsuchimoto D., Iyama T., Sakumi K., Nakagawara A., Takayama K., Nakanishi Y., Nakabeppu Y.(2011) Cancer-Related PRUNE2 Protein Is Associated with Nucleotides and Is Highly Expressed in Mature Nerve Tissues.J. Mol. Nucreosci. 44: 103-114.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定、DNAシークエンス/脳機能制御学分野）
  4. Matsumoto A, Susaki E, Onoyama I, Nakayama K, Hoshino M, Nakayama KI. Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice. Mol Cell Biol. 2011 Oct;31(20):4176-92.[PubMed]
    （発生工学実験室/分子医科学分野）
  5. Fuchiwaki T, Sun X, Fujimura K, Yamada H, Shibata K, Muta H, Podack ER, Kawauchi H, Yoshikai Y. The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice. Eur J Immunol. 2011 Oct;41(10):2947-54.[PubMed]
    （技術室/病理標本作製/感染制御学分野）
  6. Ohnishi YN, Ohnishi YH, Hokama M, Nomaru H, Yamazaki K, Tominaga Y, Sakumi K, Nestler EJ, Nakabeppu Y. FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB.　Biol Psychiatry. 2011 Sep 1;70(5):487-95.[PubMed]
    （技術室/DNAシークエンス/脳機能制御学分野）
  7. Matsumoto A, Takeishi S, Kanie T, Susaki E, Onoyama I, Tateishi Y, Nakayama K, Nakayama KI. p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2011 Sep 2;9(3):262-71.[PubMed]
    （技術室、発生工学実験室/DNAシークエンス、発生工学実験室/分子医科学分野）
  8. Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI. Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J Biol Chem. 2011 Apr 15;286(15):13754-64.[PubMed]
    （発生工学実験室/分子医科学分野）
  9. Matsumoto A, Tateishi Y, Onoyama I, Okita Y, Nakayama K, Nakayama KI. Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. Cancer Sci. 2011 Apr;102(4):749-55.[PubMed]
    （発生工学実験室/分子医科学分野）
  10. Nakaya M, Hamano S, Kawasumi M, Yoshida H, Yoshimura A, Kobayashi T. Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations. Int Immunol. 2011 Mar;23(3):195-202.[PubMed]
    （技術室/DNAシークエンス、病理標本作製/免疫制御学分野）
  11. Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.J Clin Invest. 2011 Jan;121(1):342-54.[PubMed]
    （発生工学実験室/分子医科学分野、器官発生再生学分野）
2010年（8)
  1. Okamoto F, Saeki K, Sumimoto H, Yamasaki S, Yokomizo T. Leukotriene B4 augments and restores Fc gammaRs-dependent phagocytosis in macrophages. J Biol Chem. 2010 Dec 24;285(52):41113-21.[PubMed]
    （技術室/DNAシークエンス、マススペクトル測定/九大医学部医化学分野、九大医学部生化学分野、分子免疫学分野）
  2. Ishikawa E., Miyake Y., Hara H., Saito T., Yamasaki S.(2010) Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for β-selection and TCR repertoire formation.Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19979-84.[PubMed]
    （技術室/分子免疫学分野）
  3. Iyama T., N. Abolhassani, Tsuchimoto D., Nonaka M., Nakabeppu Y. NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuculear DNA and growth arrest.Nucleic Acids Res, 2010 Aug;38(14):4834-43.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定、DNAシークエンス/脳機能制御学分野）
  4. N. Abolhassani, Iyama T., Tsuchimoto D., Sakumi K., Ohono M., M. Behmanesh, Nakabeppu Y. NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.Nucleic Acids Res, 2010 May;38(9):2891-903.[PubMed]
    （技術室/DNAシークエンス/脳機能制御学分野）
  5. Susaki E, Kaneko-Oshikawa C, Miyata K, Tabata M, Yamada T, Oike Y, Katagiri H, Nakayama KI. Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. J Biol Chem. 2010 May 14;285(20):15538-47.[PubMed]
    （発生工学実験室/分子医科学分野）
  6. Minakami R, Maehara Y, Kamakura S, Kumano O, Miyano K, Sumimoto H. Membrane phospholipid metabolism during phagocytosis in human neutrophils. Genes Cells. 2010 May;15(5):409-24.[PubMed]
    （技術室/DNAシークエンス/九大医学部生化学分野）
  7. Maita N, Nyirenda J, Igura M, Kamishikiryo J, Kohda D. Comparative structural biology of eubacterial and archaeal oligosaccharyltransferases. J Biol Chem. 2010 Feb 12;285(7):4941-50.[PubMed]
    （技術室/DNAシークエンス/構造生物学分野）
  8. Matsuda T, Takahashi-Yanaga F, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, Sasaguri T. Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity. J Pharmacol Sci. 112(3):320-6.2010.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/九大医学部臨床薬理学分野）
2009年（15)
  1. Ishikawa E, Ishikawa T, Morita Y S, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.J Exp Med. 2009 Dec 21;206(13):2879-88.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、病理標本作製/分子免疫学分野）
  2. Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y. ITPase-deficient mice show growth retardation and die before weaning. Cell Death Differ. 2009 Oct;16(10):1315-22.[PubMed]
    （技術室、発生工学実験室/発生工学実験室、電子顕微鏡観察、DNAシークエンス/脳機能制御学分野）
  3. Taniguchi K, Takeya R, Suetsugu S, Kan-o M, Narusawa M, Shiose A, Tominaga R, Sumimoto H. Mammalian Formin Fhod3 Regulates Actin Assembly and Sarcomere Organization in Striated Muscles.　J Biol Chem. 2009 Oct 23;284(43):29873-81.[PubMed]
    （技術室/電子顕微鏡観察、DNAシークエンス/増殖分化制御学分野）
  4. Sasaki K, Kajikawa M, Kuroki K, Motohashi T, Shimojima T, Park EY, Kondo S, Yagi H, Kato K, Maenaka K. Silkworm expression and sugar profiling of human immune cell surface receptor, KIR2DL1. Biochem Biophys Res Commun. 2009 Sep 25;387(3):575-80.[PubMed]
    （技術室/DNAシークエンス/構造生物学分野）
  5. Matsumoto M, Oyamada K, Takahashi H, Sato T, Hatakeyama S, Nakayama KI. Large-scale proteomic analysis of tyrosine-phosphorelation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways. Proteomics. 2009 Jul;9(13):3549-63.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/分子発現制御学分野）
  6. Saiga T, Fukuda T, Matsumoto M, Tada H, Okano HO, Okano H, Nakayama KI. Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009 Jul;29(13):3529-43.[PubMed]
    （発生工学実験室/分子発現制御学分野）
  7. Ichiyama K, Hashimoto M, Sekiya T, Nakagawa R, Wakabayashi Y, Sugiyama Y, Komai K, Saba I, Möröy T, Yoshimura A. Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity. Int Immunol. 2009 Jul;21(7):881-9.[PubMed]
    （技術室/DNAシークエンス/慶應大学医学部）
  8. Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A. A Major Lipid Raft Protein Raftlin Modulates T Cell Receptor Signaling and Enhances Th17-Mediated Autoimmune Responses. J Immunol. 2009 May 15;182(10):5929-37.[PubMed]
    （技術室、発生工学実験室/電子顕微鏡観察、発生工学実験室、DNAシークエンス/免疫制御学分野）
  9. Yoshimura T, Sonoda KH, Ohguro N, Ohsugi Y, Ishibashi T, Cua DJ, Kobayashi T, Yoshida H, Yoshimura A. Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology (Oxford). 2009 Apr;48(4):347-54.[PubMed]
    （技術室/DNAシークエンス/免疫制御学分野）
  10. Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G. An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. Biochem Biophys Res Commun. 2009 Apr 10;381(3):412-7.[PubMed]
    （技術室/DNAシークエンス、マススペクトル測定/免疫制御学分野）
  11. Nonaka M, Tsuchimoto D, Sakumi K, Nakabeppu Y. Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. FEBS J. 2009 Mar;276(6):1654-66.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定、DNAシークエンス/脳機能制御学分野）
  12. Susaki E, Nakayama K, Yamasaki L, Nakayama KI. Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5192-7.[PubMed]
    （発生工学実験室/分子発現制御学分野）
  13. Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A. Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein. Immunity. 2009 Mar 20;30(3):372-83.[PubMed]
    （技術室/DNAシークエンス、マイクロアレイ/免疫制御学分野）
  14. Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A. Sprouty4 negatively regulates protein kinase C activation by inhibiting. Oncogene. 2009 Feb 26;28(8):1076-88.[PubMed]
    （技術室/DNAシークエンス/免疫制御学分野）
  15. Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A. Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis. PLoS One. 4(5):e5467. 2009.[PubMed]
    （技術室、発生工学実験室/DNAシークエンス、発生工学実験室/免疫制御学分野）
2008年（19)
  1. Kajikawa M, Sasaki K, Wakimoto Y, Toyooka M, Motohashi T, Shimojima T, Takeda S, Park EY, Maenaka K. Efficient silkworm expression of human GPCR (nociceptin receptor) by a Bombyx mori bacmid DNA system. Biochem Biophys Res Commun. 385(3):375-9. 2008.[PubMed]
    （技術室/DNAシークエンス、電子顕微鏡観察/構造生物学分野）
  2. Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A. FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 283(49):33858-64. 2008.[PubMed]
    （技術室、発生工学実験室/病理標本作製、DNAシークエンス、発生工学実験室/免疫制御学分野）
  3. Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T. STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J Biol Chem. 283(22):14955-62. 2008.[PubMed]
    （技術室/DNAシークエンス、電子顕微鏡観察、病理標本作製/免疫制御学分野）
  4. Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A. Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads. J Immunol. 180(6):3746-56. 2008.[PubMed]
    （技術室/DNAシークエンス/免疫制御学分野）
  5. Aki D, Minoda Y, Yoshida H, Watanabe S, Yoshida R, Takaesu G, Chinen T, Inaba T, Hikida M, Kurosaki T, Saeki K, Yoshimura A. Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells.Genes Cells. (2):199-208. 2008.[PubMed]
    （技術室/DNAシークエンス/免疫制御学分野）
  6. Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T. TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway. J. Biol. Chem. 283(52):36211-20. 2008.[PubMed]
    （技術室/DNAシークエンス、マイクロアレイ/免疫制御学分野）
  7. Ohnishi YN, Sakumi K, Yamazaki K, Ohnishi YH, Miura T, Tominaga Y, Nakabeppu Y. Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol. Biol. Cell. 19(11):4717-29. 2008.[PubMed]
    （技術室/DNAシークエンス/脳機能制御学分野）
  8. Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, Yoshimura A, Kobayashi T. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J. Biol. Chem. 283(25):17003-8. 2008.[PubMed]
    （技術室/DNAシークエンス/免疫制御学分野）
  9. Sakae N, Yamasaki N, Kitaichi K, Fukuda T, Yamada M, Yoshikawa H, Hiranita T, Tatsumi Y, Kira J, Yamamoto T, Miyakawa T, Nakayama KI. Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Hum. Mol. Genet. 17(20):3191-203. 2008.[PubMed]
    （発生工学実験室/分子医科学分野）
  10. Nishimura J, Saiga H, Sato S, Okuyama M, Kayama H, Kuwata H, Matsumoto S, Nishida T, Sawa Y, Akira S, Yoshikai Y, Yamamoto M, Takeda K Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor. J. Immunol. 180(6):4032-9. 2008.[PubMed]
    （発生工学実験室/感染制御学分野、大阪大学）
  11. Saiga H, Nishimura J, Kuwata H, Okuyama M, Matsumoto S, Sato S, Matsumoto M, Akira S, Yoshikai Y, Honda K, Yamamoto M, Takeda K. Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium. J. Immunol. 181(12):8521-7. 2008.[PubMed]
    （発生工学実験室/大阪大学）
  12. Shirane M, Ogawa M, Motoyama J, Nakayama KI. Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse. Genes Cells. 13(6):635-51. 2008.[PubMed]
    （発生工学実験室/分子医科学分野）
  13. Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, Yoshida R, Okamoto F, Hanada T, Torisu K, Takaesu G, Kobayashi T, Yasukawa H, Yoshimura A. Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis. Hepatology. 47(5):1644-54. 2008.[PubMed]
    （技術室/病理標本作製、DNAシークエンス/免疫制御学分野）
  14. Shiraishi H, Yoshida H, Saeki K, Miura Y, Watanabe S, Ishizaki T, Hashimoto M, Takaesu G, Kobayashi T, Yoshimura A. Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells. Int Immunol. 20(9):1219-29. 2008.[PubMed]
    （技術室/病理標本作製、DNAシークエンス/免疫制御学分野）
  15. Yamamoto S., Tanaka K., Sakimura R., Okada T., Nakamura T., Li Y., Takasaki M., Nakabeppu Y., Iwamoto Y.(2008) Suberoylanilide hidroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines. Anticancer Res. 28: 1585－1592.[PubMed]
    （技術室/電子顕微鏡観察/九大医学部整形外科、脳機能制御学分野）
  16. Oka S., Ohno M., Tsuchimoto D., Sakumi K., Furuichi M., Nakabeppu Y. (2008) Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. EMBO J. 27: 421－432.[PubMed]
    （技術室/電子顕微鏡観察、DNAシークエンス/脳機能制御学分野）
  17. Ichikawa J., Tsuchimoto D., Oka S., Ohno M., Furuichi M., Sakumi K., Nakabeppu Y.(2008) Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death. DNA Repair 7: 418-130.[PubMed]
    （技術室/電子顕微鏡観察、DNAシークエンス/脳機能制御学分野）
  18. Takeya R., Taniguchi K., Narumiya S., Sumimoto H.(2008) The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells. EMBO J. 27: 618-628.[PubMed]
    （技術室/DNAシークエンス/増殖分化制御学分野）
  19. Igura M., Maita N., Kamishikiryo J., Yamada M., Obita T., Maenaka K., Kohda D.(2008) Structure-guided identification of a new catalytic motif of oligosaccharyltransferase. EMBO J. 27: 234-243.[PubMed]
    （技術室/電子顕微鏡観察/ワクチン開発構造生物学分野）
2007年（9)
  1. Torisu T, Sato N, Yoshiga D, Kobayashi T, Yoshioka T, Mori H, Iida M, Yoshimura A. The dual function of hepatic SOCS3 in insulin resistance in vivo. Genes Cells. 12(2):143-54. 2007.[PubMed]
    （技術室、発生工学実験室/病理標本作製、DNAシークエンス、発生工学実験室、マイクロアレイ /免疫制御学分野）
  2. Mori H, Shichita T, Yu Q, Yoshida R, Hashimoto M, Okamoto F, Torisu T, Nakaya M, Kobayashi T, Takaesu G, Yoshimura A. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Biochem Biophys Res Commun. 359(4):952-8. 2007.[PubMed]
    （技術室/病理標本作製、電子顕微鏡観察/免疫制御学分野）
  3. Nishinakamura H, Minoda Y, Saeki K, Koga K, Takaesu G, Onodera M, Yoshimura A, Kobayashi T. An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity. Int Immunol. 19(5):609-19. 2007.[PubMed]
    （技術室/マススペクトル測定、DNAシークエンス/免疫制御学分野）
  4. Honbou K, Minakami R, Yuzawa S, Takeya R, Suzuki NN, Kamakura S, Sumimoto H, Inagaki F. Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding. EMBO J. 26(4):1176-86. 2007.[PubMed]
    （技術室/DNAシークエンス/北海道大学、増殖分化制御学分野）
  5. Matsumura Y, Kobayashi T, Ichiyama K, Yoshida R, Hashimoto M, Takimoto T, Tanaka K, Chinen T, Shichita T, Wyss-Coray T, Sato K, Yoshimura A. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. J Immunol. 179(4):2170-9. 2007.[PubMed]
    （技術室/DNAシークエンス/免疫制御学分野）
  6. Onoyama I, Tsunematsu R, Matsumoto A, Kimura T, de Alborán IM, Nakayama K, Nakayama KI. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med. (12):2875-88. 2007.[PubMed]
    （発生工学実験室/分子医科学分野）
  7. Igura M., Maita N., Obita T., Kamishikiryo J., Maenaka K., Kohda D.(2007) Purification, crystallization and preliminary X-ray diffraction studies of the soluble domain of the oligosaccharyltransferase STT3 subunit from the thermophilic archaeon Pyrococcus furiosus.Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.F63: 798-801.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定、DNAシークエンス/ワクチン開発構造生物学分野）
  8. Taniguchi K., Kohno RI., Ayada T., Kato R., Ichiyama K., Morisada T., Oike Y., Yonemitsu Y., Maehara Y., Yoshimura A.(2007) Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor-3 signaling.Mol Cell Biol.27(12):4541-50.[PubMed]
    （技術室、発生工学実験室/病理組織標本作製、DNAシークエンス、発生工学実験室/免疫制御学分野）
  9. Taniguchi K., Ayada T., Ichiyama K., Kohno R., Yonemitsu Y., Minami Y., Kikuchi A., Maehara Y., Yoshimura A.(2007) Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling. Biochem Biophys Res Commun.26;352(4):896-902.[PubMed]
    （技術室、発生工学実験室/病理組織標本作製、DNAシークエンス、発生工学実験室/免疫制御学分野）
2006年（15)
  1. Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell. 1(1):101-12. 2006.[PubMed]
    （発生工学実験室/慶應義塾大学）
  2. Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med. 203(6):1391-7. 2006.[PubMed]
    （技術室/DNAシークエンス、マススペクトル測定、病理標本作製/免疫制御学分野）
  3. Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Hashimoto M, Yagita H, Nawata H, Yoshimura A. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology. 130(2):373-88. 2006.[PubMed]
    （技術室、発生工学実験室/病理標本作製、DNAシークエンス、発生工学実験室、電子顕微鏡観察、マススペクトル測定/免疫制御学分野）
  4. Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A. Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med. 203(4):1021-31. 2006.[PubMed]
    （技術室、発生工学実験室/病理標本作製、DNAシークエンス、発生工学実験室、電子顕微鏡観察、マススペクトル測定/免疫制御学分野）
  5. Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Maehara Y, Iida M, Yoshimura A. Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Gastroenterology. 131(1):179-93. 2006.[PubMed]
    （技術室、発生工学実験室/病理標本作製、DNAシークエンス、発生工学実験室、電子顕微鏡観察、マススペクトル測定/免疫制御学分野）
  6. Aoi N, Masuda T, Murakami D, Yajima T, Mizubuchi H, Yamada H, Kawauchi H, Yoshikai Y. IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells. J Allergy Clin Immunol. 2006 Jun;117(6):1359-66.[PubMed]
    （技術室/病理標本作製/感染制御学分野）
  7. Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I. Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. J Biol Chem. 281(7):4495-506. 2006.[PubMed]
    （技術室/マススペクトル測定/免疫制御学分野、福島医大）
  8. Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30.[PubMed]
    （技術室/マススペクトル測定/免疫制御学分野）
  9. Takaki H, Minoda Y, Koga K, Takaesu G, Yoshimura A, Kobayashi T. TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation. Genes Cells. 11(8):871-82. 2006.[PubMed]
    （技術室、発生工学実験室/DNAシークエンス、発生工学実験室/免疫制御学分野）
  10. Lu Y, Fukuyama S, Yoshida R, Kobayashi T, Saeki K, Shiraishi H, Yoshimura A, Takaesu G. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. J Biol Chem. 2006 Dec 1;281(48):36683-90. 2006.[PubMed]
    （技術室/DNAシークエンス/免疫制御学分野）
  11. Hara K, Nakayama KI, Nakayama K. Geminin is essential for the development of preimplantation mouse embryos. Genes Cells. Nov;11(11):1281-93. 2006.[PubMed]
    （発生工学実験室/東北大学）
  12. Tsunematsu R, Nishiyama M, Kotoshiba S, Saiga T, Kamura T, Nakayama KI. Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Mol Cell Biol. 26(16):6157-69. 2006.[PubMed]
    （発生工学実験室/分子医科学分野）
  13. Shiraishi H, Okamoto H, Yoshimura A, Yoshida H. ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1. J Cell Sci. 119(Pt 19):3958-66. 2006.[PubMed]
    （技術室/電子顕微鏡観察、DNAシークエンス、病理標本作製/免疫制御学分野、佐賀大学）
  14. Fotovati A, Nakayama K, Nakayama KI. Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice. Cell Div. 2006 Apr 7;1:4.[PubMed]
    （技術室、発生工学実験室/電子顕微鏡観察、発生工学実験室/分子医科学分野）
  15. Shirane M., Nakayama KI.(2006) Protrudin induces neurite formation by directional membrane trafficking.Science, 314: 818-21.[PubMed]
    （技術室/電子顕微鏡観察/分子発現制御学分野）
2005年（7)
  1. Taketomi T, Yoshiga D, Taniguchi K, Kobayashi T, Nonami A, Kato R, Sasaki M, Sasaki A, Ishibashi H, Moriyama M, Nakamura K, Nishimura J, Yoshimura A. Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci. 8(7):855-7. 2005.[PubMed]
    （技術室/DNAシークエンス、マススペクトル測定、病理標本作製/免疫制御学分野）
  2. Nonami A, Taketomi T, Kimura A, Saeki K, Takaki H, Sanada T, Taniguchi K, Harada M, Kato R, Yoshimura A. The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1. Genes Cells. 10(9):887-95. 2005.[PubMed]
    （技術室/DNAシークエンス、電子顕微鏡観察、病理標本作製/免疫制御学分野）
  3. Torisu K, Tsuchimoto D, Ohnishi Y, Nakabeppu Y. Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein. J Biochem. 138(6):763-72. 2005.[PubMed]
    （技術室、発生工学実験室/DNAシークエンス、発生工学実験室/脳機能制御学分野）
  4. Suehiro,Y., Muta,K., Nakashima,M. et al(2005) A novel mechanism in suppression of erythropoiesis during inflammation: a crucial role of RCAS1. Eur. J. Haematology, 74:365-373.[PubMed]
    （技術室/電子顕微鏡観察/九大医学研究院臨床免疫学部門）
  5. 神田大輔(2005)蛋白質核酸酵素vol.50.No10 1303-1310.[PubMed]
    （技術室/電子顕微鏡観察/ワクチン開発構造生物学分野）
  6. Kaneko-Oshikawa,C., Nakagawa,T., Yamada,M., Yoshikawa,H., Matsumoto,M., Yada,M., Hatakeyama,S., Nakayama,K., and Nakayama,KI.(2005) Mammalian E4 Is Required for Cardiac Development and Maintenance of the Nervous System. Mol. Cell Biol., 25: 10953-10964.[PubMed]
    （技術室/電子顕微鏡観察、発生工学実験室/分子発現制御学分野）
  7. Matsumoto M., Hatakeyama S., Oyamada K., Oda Y., Nishimura T., Nakayama KI.(2005) Large-scale analysis of the human ubiquitin-related proteome.Proteomics, 5: 4145-51.[PubMed]
    （技術室/プロテオミクスセンター、マススペクトル測定/分子発現制御学分野）
2004年（8)
  1. Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 18(24):3055-65. 2004.[PubMed]
    （技術室/マススペクトル測定、プロテオミクスセンター/分子医科学分野）
  2. Nishiyama M, Nakayama K, Tsunematsu R, Tsukiyama T, Kikuchi A, Nakayama KI. Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol Cell Biol. 24(19):8386-94. 2004.[PubMed]
    （発生工学実験室/分子医科学分野）
  3. Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem. 279(10):9417-23. 2004.[PubMed]
    （発生工学実験室/分子医科学分野）
  4. Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI. Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell. 6(5):661-72. 2004.[PubMed]
    （発生工学実験室/分子医科学分野）
  5. Ide Y, Tsuchimoto D, Tominaga Y, Nakashima M, Watanabe T, Sakumi K, Ohno M, Nakabeppu Y. Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood. 104(13):4097-103. 2004.[PubMed]
    （発生工学実験室/脳機能制御学分野）
  6. Ichinoe,A., Behmanesh,M., Tominaga,Y., Ushijima,Y., Hirano,S., Sakai,Y., Tsuchimoto,D., Sakumi,K., Wake,N., and Nakabeppu,Y.(2004)Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts. Nucleic Acids Res., 32:477-87.[PubMed]
    （技術室/電子顕微鏡観察/脳機能制御学分野）
  7. Nakabeppu,Y., Tsuchimoto,D., Ichinoe,A., Ohno,M., Ide,Y., Hirano,S., Yoshimura,D., Tominaga,Y., Furuichi,M. and Sakumi,K. (2004) Biological Significance of the Defense Mechanisms against Oxidative Damage in Nucleic Acids Caused by Reactive Oxygen Species: from Mitochondria to Nuclei. Ann N. Y. Acad. Sci., 1011, 101-112.[PubMed]
    （技術室/電子顕微鏡観察/脳機能制御学分野）
  8. Shirasawa,S., Sugiyama,S., Baba,I., Inokuchi,J., Sekine,S., Ogino,K., Kawamura,Y., Dohi,T., Fujimoto,M., and Sasazuki,T.(2004) Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc. Natl. Acad. Sci. U.S.A., 101:13921-6.[PubMed]
    （発生工学実験室/免疫遺伝学分野、国立国際医療センター臨床病理研究部）
2003年（5)
  1. Xu P, Yoshioka K, Yoshimura D, Tominaga Y, Nishioka T, Ito M, Nakabeppu Y. In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis. J Biol Chem. 278(48):48422-33. 2003.[PubMed]
    （発生工学実験室/脳機能制御学分野）
  2. Nakayama K, Hatakeyama S, Maruyama S, Kikuchi A, Onoé K, Good RA, Nakayama KI. Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc Natl Acad Sci U S A. 100(15):8752-7. 2003.[PubMed]
    （発生工学実験室/分子医科学分野）
  3. Tahara,K., Tsuchimoto,D., Tominaga,Y., Asoh,S., Ohta,S., Kitagawa,M., Horie,H., Kadoya,T. and Nakabeppu,Y. (2003) DeltaFosB but not FosB Induces Delayed Apoptosis Independent of Cell Proliferation in the Rat1a Embryo Cell Line. Cell Death Diff., 10:496-507.[PubMed]
    （技術室/電子顕微鏡観察/脳機能制御学分野）
  4. Yoshimura,D., Sakumi,K., Ohno,M., Sakai,Y., Furuichi,M., Iwai,S. and Nakabeppu,Y. (2003) An oxidized purine nucleoside triphosphatase, MTH1 suppresses cell death caused by oxidative stress. J. Biol. Chem., 278:37965-37973.[PubMed]
    （技術室/電子顕微鏡観察/脳機能制御学分野）
  5. Saeki,K., Miura,Y., Aki,D., Kurosaki,T., and Yoshimura,A.(2003) The B cell-specific major raft protein, Raftlin is necessary for the integrity of lipid raft and BCR signal transduction. EMBO J., 22:3015-3026.[PubMed]
    （技術室/マススペクトル測定/免疫制御学分野）
2002年（8)
  1. Kanematsu T, Jang IS, Yamaguchi T, Nagahama H, Yoshimura K, Hidaka K, Matsuda M, Takeuchi H, Misumi Y, Nakayama K, Yamamoto T, Akaike N, Hirata M, Nakayama K. Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J. 21(5):1004-11. 2002.[PubMed]
    （発生工学実験室/九大歯学部、分子医科学分野）
  2. Ide Y, Tsuchimoto D, Tominaga Y, Iwamoto Y, Nakabeppu Y. Characterization of the genomic structure and expression of the mouse Apex2 gene. Genomics. 81(1):47-57. 2002.[PubMed]
    （技術室/電子顕微鏡観察/脳機能制御学分野）
  3. Sasaki,M., Miyazaki,K., Koga,Y., Kimura,G., Nomoto,K., and Yoshida,H.(2002)Calcineurin-dependent mitochondrial disturbances in calcium-induced apoptosis of human immunodeficiency virus gp160-expressing CD4+ cells. J. Virol., 76(1):416-20.[PubMed]
    （技術室/電子顕微鏡観察/免疫制御学分野）
  4. Hara,H., Takeda,A., Takeuchi,M., Wakeham,AC., Itie,A., Sasaki,M., Mak,TW., Yoshimura,A., Nomoto,K., and Yoshida,H.(2002)The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes. J.Immunology, 168:2288-2295.[PubMed]
    （技術室/電子顕微鏡観察/免疫制御学分野）
  5. Yoshida,H., Okada,Y., Kinoshita,N., Hara,H., Sasaki,M., Sawa,H., Nagashima,K., Mak,TW., Ikeda,K., and Motoyama,N.(2002)Differential requirement for Apaf1 and Bcl-X(L) in the regulation of programmed cell death during development. Cell Death Differ., 9:1273-6.[PubMed]
    （技術室/電子顕微鏡観察/免疫制御学分野）
  6. Nakamichi,I., Hatakeyama,S., and Nakayama,KI.(2002)Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18. Mol. Biol. Cell, 13:3441-3451.[PubMed]
    （技術室/電子顕微鏡観察/分子発現制御学分野）
  7. Minamishima,YA., Nakayama,K., and Nakayama,K.(2002) Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Cancer Res., 62:995-9.[PubMed]
    （発生工学実験室/分子発現制御学分野）
  8. Miyamoto,A., Nakayama,K., Imaki,H., Hirose,S., Jiang,Y., Abe,M., Tsukiyama,T., Nagahama,H., Ohno,S., Hatakeyama,S., and Nakayama,KI.(2002) Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature, 416:865-9.[PubMed]
    （発生工学実験室/分子発現制御学分野）
2001年（7)
  1. Nakabeppu,Y. (2001) Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage. Progress of Nucleic Acid Research and Molecular Biology, 68:75-94.[PubMed]
    （技術室/電子顕微鏡観察/脳機能制御学分野）
  2. Nakabeppu,Y., Tominaga,Y., Tsuchimoto,D., Ide,Y., Hirano,S., Sakai,Y., Sakumi,K. and Furuichi,M. (2001) Mechanisms Protecting Genomic Integrity from Damage Caused by Reactive Oxygen Species: Implications for Carcinogenesis and Neurodegeneration. Environmental Mutagen Research, 23:197-209.[PubMed]
    （技術室/電子顕微鏡観察/脳機能制御学分野）
  3. Miyazaki,K., Yoshida,H., Sasaki,M., et al (2001) Caspase-independent cell death and mitochondrial disruption observed in the Apaf1-deficient cells. J.Biochem.(Tokyo)129:963-969[PubMed]
    （技術室/電子顕微鏡観察/免疫制御学分野）
  4. Tsuchimoto,D., Sakai,Y., Sakumi,K., Nishioka,K., Sasaki,M., Fujiwara,T. and Nakabeppu,Y. (2001) Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen. Nucleic Acids Res., 29:2349-2360.[PubMed]
    （技術室/電子顕微鏡観察/脳機能制御学分野）
  5. Tsukiyama,T., Ishida,N., Shirane,M., Minamishima,YA., Hatakeyama,S., Kitagawa,M., Nakayama,K., and Nakayama,K.(2001) Down-regulation of p27Kip1 expression is required for development and function of T cells. J. Immunol., 166:304-12.[PubMed]
    （発生工学実験室/分子発現制御学分野）
  6. Nagahama,H., Hatakeyama,S., Nakayama,K., Nagata,M., Tomita,K., and Nakayama,K.(2001) Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development. Anat. Embryol., 203:77-87.[PubMed]
    （発生工学実験室/分子発現制御学分野）
  7. Fukui,Y., Hashimoto,O., Sanui,T., Oono,T., Koga,H., Abe,M., Inayoshi,A., Noda,M., Oike,M., Shirai,T., and Sasazuki,T.(2001) Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature, 412:826-31.[PubMed]
    （発生工学実験室/免疫遺伝学分野）
2000年（3)
  1. Shimoda,K., Kato,K., Aoki,K., Matsuda,T., Miyamoto,A., Shibamori,M., Yamashita,M.,.Numata,A., Takase,K., Kobayashi,S., Shibata,S., Asano,Y., Gondo,H., Sekiguchi,K., Nakayama,K., Nakayama,T., Okamura,T., Okamura,S., Niho,Y., and Nakayama,K.(2000) Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity,13:561-71.[PubMed]
    （発生工学実験室/分子発現制御学分野）
  2. Nakayama,K., Nagahama,H., Minamishima,YA., Matsumoto,M., Nakamichi,I., Kitagawa,K., Shirane,M., Tsunematsu,R., Tsukiyama,T., Ishida,N., Kitagawa,M., Nakayama,K., and Hatakeyama,S.(2000) Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J.,19:2069-81.[PubMed]
    （発生工学実験室/発生工学分野）
  3. Kitagawa,K., Kawamoto,T., Kunugita,N., Tsukiyama,T., Okamoto,K., Yoshida,A., Nakayama,K., and Nakayama,K.(2000) Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett., 476:306-11.[PubMed]
    （発生工学実験室/分子発現制御学分野）