Medical Institute of Bioregulation, Kyushu University

2023（4)

1. Sakamoto, M., Abe, S., Miki, Y., Miyanari, Y., Sasaki, H. & Ishiuchi, T. Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development. Genes Dev. 37:590-604, 2023. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing) / Yamanashi University）
2. Unoki, M., Velasco, G., Kori, S., Arita, K., Daigaku, Y., Au Yeung, W.K., Fujimoto, A., Ohashi, H., Kubota, T., Miyake, K. & Sasaki, H. Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome with distinctive genome-wide DNA hypomethylation. Hum. Mol. Genet. 32:1439-1456, 2023. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing) / Division of Epigenomics and Development）
3. Uemura, S., Maenohara, S., Inoue, K., Ogonuki, N., Matoba, S., Ogura, A., Kurumizaka, M., Yamagata, K., Sharif, J., Koseki, H., Ueda, K., Unoki, M. & Sasaki, H. UHRF1 is essential for proper cytoplasm architecture and function of mouse oocyte and derived embryo. Life Sci. Alliance 6:e202301904, 2023. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing, Electron Microscopes) / Division of Epigenomics and Development）
4. Uehara, R., Au Yeung, W.K., Toriyama, K., Ohishi, H., Kubo, N., Toh, H., Suetake, I., Shirane, K. & Sasaki, H. The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes. PLoS Genet. 19:e1010855, 2023. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing) / Division of Epigenomics and Development）

2022（3)

1. Fujimoto M., Takii R., Matsumoto M., Okada M., Nakayama KI., Nakato R., Fujiki K., Shirahige K., Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nature Commun., 13: 4355, 2022. [PubMed]
   (Laboratory for Research Support, Research Promotion Unit (Proteome Analysis) / Yamaguchi University «Joint Usage/Research Center»)
2. Higa T., Okita Y., Matsumoto A., Nakayama S., Oka T., Sugahara O., Koga D., Takeishi S., Nakatsumi H., Hosen N., Robine S., Taketo MM., Sato T., Nakayama KI. Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nature Commun. 13: 1500, 2022. [PubMed]
   (Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Cell Biology）
3. Yano S., Ishiuchi T., Abe S., Namekawa S.H., Huang G., Ogawa Y., Sasaki, H. Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes. Nat. Commun. 2022 Aug 3;13:4440. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing) / Division of Epigenomics and Development）
4. Mise S., Matsumoto A., Shimada K., Hosaka T., Takahashi M., Ichihara K., Shimizu H., Shiraishi C., Saito D., Suyama M., Yasuda T., Ide T., Izumi Y., Bamba T., Kimura-Someya T., Shirouzu M., Miyata H., Ikawa M., Nakayama KI. Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nature Commun. 13, 1071 (2022). [PubMed]
   （Laboratory for Research Support, Research Promotion Unit / Division of Cell Biology）
5. Mizuno Y, Abolhassani N, Mazzei G, Saito T, Saido, TC, Yamasaki R, J. Kira, Nakabeppu Y. Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the App[NL-G-F/NL-G-F] knock-in mouse model of Alzheimer's disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior. Neurosci Res. 2022 Apr;177:118-134. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Neurofunctional Genomics）

2021（15)

1. Nakajima H., Fujita S., Kakae M., Nagayasu K., Oh-hora M., Shirakawa H., Kaneko S. Orai2 channel regulates prostaglandin E2 production in TNFα/IL1α-stimulated astrocytes. Glia. 2022;70:1666–1680. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Graduate School and Faculty of Pharmaceutical Sciences, Kyoto University）
2. Nakashima Y., Gotoh K., Mizuguchi S., Setoyama D., Takata Y., Kanno T., D. Kang . Attenuating Effect of Chlorella Extract on NLRP3 Inflammasome Activation by Mitochondrial Reactive Oxygen Species. Front Nutr. 2021 Oct 8;8:763492. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Electron Microscopes) / Clinical Laboratories, Kyushu University Hospital）
3. Mizuguchi S., Gotoh K., Nakashima Y., Setoyama D., Takata Y., Ohga S., D. Kang. Mitochondrial Reactive Oxygen Species Are Essential for the Development of Psoriatic Inflammation. Front Immunol. 2021 Aug 6;12:714897. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Electron Microscopes) / Clinical Laboratories, Kyushu University Hospital）
4. Nita A., Matsumoto A., Tang R., Shiraishi C., Ichihara K., Saito D., Suyama M., Yasuda T., Tsuji G., Furue M., Katayama B., Ozawa T., Murata T., Dainichi T., Kabashima K., Hatano A., Matsumoto M., Nakayama KI. A ubiquitin-like protein encoded by the “noncoding” RNA TINCR promotes keratinocyte proliferation and wound healing. PLoS Genet. 2021 Aug 5;17(8):e1009686. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit / Division of Cell Biology / Division of Bioinformatics）
5. Matsuzaki F., Uda S., Yamauchi Y., Matsumoto M., Soga T., Maehara K., Ohkawa Y., Nakayama KI., Kuroda S., Kubota H. An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver. Cell Rep. 2021 Aug 24;36(8):109569. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Proteome Analysis) / Division of Integrated Omics / Division of Transcriptomics / Division of Cell Biology）
6. Ichihara K., Matsumoto A., Nishida H., Kito Y., Shimizu H., Shichino Y., Iwasaki S., Imami K., Ishihama Y., Nakayama KI.　Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons. Nucleic Acids Res. 2021 Jul 21;49(13):7298-7317. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing) / Division of Cell Biology）
7. Kawamura A., Katayama Y., Kakegawa W., Ino D., Nishiyama M., Yuzaki M., Nakayama KI. The autism-associated protein CHD8 is required for cerebellar development and motor function. Cell Rep. 35: 108932, 2021. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Pathological specimen preparation, Proteome Analysis, Next-Generation Sequencing) / Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Cell Biology）
8. Nita A., Muto Y., Katayama Y., Matsumoto A., Nishiyama M., Nakayama KI. The autism-related protein CHD8 contributes to the stemness and differentiation of mouse hematopoietic stem cells. Cell Rep. 2021 Feb 2;34(5):108688. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing) / Division of Cell Biology）
9. Ishiuchi T., Abe S., Inoue K., Wan Kin Au Yeung, Miki Y., Ogura A., Sasaki H. Reprogramming of the histone H3.3 landscape in the early mouse embryo. Nat. Struct. Mol. Biol. 2021 Jan;28(1):38-49. [PubMed]
   （Research Promotion Unit / Division of Epigenomics and Development）
10. Morikawa T, Ohishi H, Kosaka K, Shimojo T, Nagano A, Taniguchi I, Fujioka R, Moriyama K, Unoki M, Takahashi M, Nakao M, Izumi Y, Bamba T, Sasaki H , Miura S, Shibata H. Ddhd1 knockout mouse as a model for familial spastic paraplegia. Biosci Rep. 41(2): BSR20204171 (2021). [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing) / Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Epigenomics and Development）
11. Yasuda T, Saito Y, Ono C, Kawata K, Baba A, Baba Y. Generation and characterization of CD19-iCre mice as a tool for efficient and specific conditional gene targeting in B cells. Sci. Rep. 11, 5524 (2021). [PubMed]
    （Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Immunology and Genome Biology）
12. Hasuwa, H., Iwasaki, Y.W., Au Yeung, W.K., Ishino, K., Masuda, H., Sasaki, H. & Siomi, H. Production of functional oocytes requires maternally expressed PIWI genes and piRNAs in golden hamsters. Nat. Cell Biol. 23, 1002-1012 (2021). [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing) / Keio University / Division of Epigenomics and Development）
13. Kibe K., Shirane K., Ohishi H., Uemura S., Toh H., Sasaki H. The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes. PLoS Genet. 2021 May 28;17(5):e1009570. [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (Next-Generation Sequencing) / Division of Epigenomics and Development）
14. Abe S., Nagatomo H., Sasaki H., Ishiuchi T. A histone H3.3K36M mutation in mice causes an imbalance of histone modifications and defects in chondrocyte differentiation. Epigenetics. 2021 Oct;16(10):1123-1134. [PubMed]
    （Research Promotion Unit / Division of Epigenomics and Development）
15. Mizuno Y., N. Abolhassani, G. Mazzei, Sakumi K., Saito T., C Saido T., Ninomiya T., Iwaki T., Yamasaki R., Kira J., Nakabeppu Y. MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer’s Disease. Oxid Med Cell Longev. 2021 Dec 21;2021:8635088. [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (Microarray, Next-Generation Sequencing) / Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Neurofunctional Genomics）

2020（13)

1. Takahashi H., A. Ranjan, S. Chen, Suzuki H., Shibata M., Hirose T., Hirose H., Sasaki K., Abe R., K. Chen, Y. He, Y. Zhang, Takigawa I., Tsukiyama T., Watanabe M., Fujii S., Iida M., Yamamoto J., Yamaguchi Y., Suzuki Y., Matsumoto M., Nakayama KI, M P Washburn, A Saraf, L Florens, Sato S., Tomomori-Sato C., R C Conaway, J W Conaway, Hatakeyama S. The role of Mediator and Little Elongation Complex in transcription termination. Nat Commun. 2020 Feb 26;11(1):1063. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Proteome Analysis) / Yokohama City University «Joint Usage/Research Center» / Division of Cell Biology）
2. Kawamura A., Abe Y., Seki F., Katayama Y., Nishiyama M., Takata N., Tanaka F K., Okano H., Nakayama KI. Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain. Mol Brain. 2020 Nov 23;13(1):160. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Cell Biology）
3. Miura S., and Suzuki A. Induction of Steatohepatitis and Liver Tumorigenesis by Enforced Snail Expression in Hepatocytes. Am. J. Pathol. 190, 1271-1283. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Pathological specimen preparation, Electron Microscopes, DNA Sequencing) / Division of Organogenesis and Regeneration）
4. Yamauchi Y., Nita A., Nishiyama M., Muto Y., Shimizu H., Nakatsumi H., Nakayama KI. Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development. Genes Cells. 2020 Jun;25(6):427-438. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Pathological specimen preparation) / Division of Cell Biology）
5. Horisawa K., Udono M., Ueno K., Ohkawa Y., Nagasaki M., Sekiya S., Suzuki A. The dynamics of transcriptional activation by hepatic reprogramming factors. Mol Cell 79, 660-676. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Proteome Analysis) / Division of Organogenesis and Regeneration / Division of Transcriptomics）
6. Kito Y., Matsumoto M., Hatano A., Takami T., Oshikawa K., Matsumoto A., Nakayama KI. Cell cycle-dependent localization of the proteasome to chromatin. Sci. Rep. 2020 Apr 2;10(1):5801. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Proteome Analysis) / Division of Cell Biology）
7. Julien Richard Albert, Wan Kin Au Yeung, Keisuke Toriyama, Hisato Kobayashi, Ryutaro Hirasawa, Julie Brind'Amour, Aaron Bogutz, Hiroyuki Sasaki, Matthew Lorincz. Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo. Nat Commun. 2020 Oct 27;11(1):5417. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (DNA Sequencing) / Division of Epigenomics and Development）
8. Ohishi H., Wan Kin Au Yeung, Unoki M., Ichiyanagi K., Fukuda K., Maenohara S., Shirane K., Chiba H., Sado T., and Sasaki H. Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells. Genes Cells2020 Jan;25(1):54-64. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (DNA Sequencing) / Division of Epigenomics and Development）
9. Onoyama I., Nakayama S., Shimizu H. Nakayama KI. Loss of Fbxw7 impairs development of and induces heterogeneous tumor formation in the mouse mammary gland. Cancer Res. 2020 Dec 15;80(24):5515-5530. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Cell Biology）
10. Mayanagi K., Oki K., Miyazaki N., Ishino S., Yamagami T., Morikawa K., Iwasaki K., Kohda D., Shirai T., Ishino Y. Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy. BMC Biology 18, 152 (2020). [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (Electron Microscopes) / Division of Structural Biology, Faculty of Agriculture, Kyushu University）
11. Inada H., Udono M., Matsuda-Ito K., Horisawa K., Ohkawa Y., Miura S., Goya T., Yamamoto J., Nagasaki M., Ueno K., Saitou D., Suyama M., Maehara Y., Kumamaru W., Ogawa Y., Sekiya S., Suzuki A. Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells. Nat Commun.11, 5292 (2020). [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (Pathological specimen preparation, Electron Microscopes, DNA Sequencing) / Division of Organogenesis and Regeneration / Division of Transcriptomics / Division of Bioinformatics）
12. Koga Y., Tsuchimoto D., Hayashi Y., N. Abolhassani, Yoneshima Y., Sakumi K., Nakanishi H., Toyokuni S., Nakabeppu Y. Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy. JCI Insight . 2020 Nov 19;5(22):140229. [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (DNA Sequencing, Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Neurofunctional Genomics）
13. Iwamori T., Iwamori N., Matsumoto M., Imai H., Ono E. Novel Localizations and Interactions of Intercellular Bridge Proteins Revealed by Proteomic Profiling. Biol. Reprod. 2020 Apr 24;102(5):1134-1144. [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (Proteome Analysis, Pathological specimen preparation) / Faculty of Medical Sciences, Kyushu University）

2019（11)

1. Yamauchi S, Mano S, Oikawa K, Hikino K, Teshima KM, Kimori Y, Nishimura M, Shimazaki K, Takemiya A. Autophagy controls reactive oxygen species homeostasis in guard cells that is essential for stomatal opening. Proc Natl Acad Sci USA 116: 19187-19192 (2019). [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Proteome Analysis) / Graduate School of Sciences and Technology for Innovation, Yamaguchi University «Joint Usage/Research Center»）
2. Takii R., Fujimoto M., Matsumoto M., P. Srivastava, A. Katiyar, Nakayama KI.,Nakai A. The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment. EMBO J.2019 Dec 16;38(24). [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Proteome Analysis) / Biochemistry and Molecular Biology, Graduate School of Medicine, Yamaguchi University «Joint Usage/Research Center»）
3. Aktar S, Sasaki H, Unoki M. Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation. Genes Cells. 2019 Nov 13;24(11):746-755. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (DNA Sequencing) / Division of Epigenomics and Development）
4. Terada M., Kawamata M., Kimura R., Sekiya S., Nagamatsu G., Hayashi K., Horisawa K., Suzuki A. Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells. Genesis. 2019 Nov;57(11-12):e23334. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Division of Organogenesis and Regeneration）
5. Hanawa-Suetsugu K, Itoh Y, Ab Fatah M, Nishimura T, Takemura K, Takeshita K, Kubota S, Miyazaki N, Wan Mohamad Noor WNI, Inaba T, Nguyen NTH, Hamada-Nakahara S, Oono-Yakura K, Tachikawa M, Iwasaki K, Kohda D, Yamamoto M, Kitao A, Shimada A, Suetsugu S. Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7. Nat Commun. 2019 Oct 18;10(1):4763. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Electron Microscopes) / Nara Institute of Science and Technology）
6. Inoguchi Y., Ichiyanagi K., Ohishi H., Maeda Y., Sonoda N., Ogawa Y., Inoguchi T., Sasaki H. Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring. Sci Rep. 2019 Jul 15;9(1):10181. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (DNA Sequencing) / Division of Epigenomics and Development）
7. Ishiuchi T., Ohishi H., Sato T., Kamimura S., Yorino M., Abe S., Suzuki A., Wakayama T., Suyama M., Sasaki H. Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development. Cell Rep. 2019 May 7;27(6):1742-1754. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit / Division of Epigenomics and Development）
8. Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI. Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. J Exp Med. 2019 Apr 1;216(4):950-965. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Microarray) / Division of Cell Biology）
9. Shimizu H, Takeishi S, Nakatsumi H, Nakayama KI. Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells. JCI Insight. 2019 Feb 21; 4(4): e125138. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (LSM) / Division of Cell Biology）
10. Unoki M, Funabiki H, Velasco G, Francastel C, Sasaki H. CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome. J Clin Invest. 2019 Jan 2;129(1):78-92. [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (Proteome Analysis) / Division of Epigenomics and Development）
11. Haruki R, Kouno H, Hosoyamada M, Ogawa T, Yanai N, Kimizuka N.　Oligo(ethylene glycol)/alkyl-modified Chromophore Assemblies for Photon Upconversion in Water.　Chem Asian J. 2019 Jan 2. [PubMed]
    （Laboratory for Research Support, Research Promotion Unit (Electron Microscopes) / Department of Applied Chemistry, Faculty of Engineering, Kyushu University）

2018（7)

1. Abe Y., Honsho M., Itoh R., Kawaguchi R., Fujitani M., Fujiwara K., Hirokane M., Matsuzaki T., Nakayama K., Ohgi R., Marutani T., Nakayama KI, Yamashita T., Fujiki Y. Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum.　Life Sci Alliance. 2018 Dec 3;1(6):e201800062. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit / Division of Organelle Homeostasis）
2. Imai T., Matsumura T., S. Mayer-Lambertz, C. A. Wells, Ishikawa E., S. K. Butcher, T. C. Barnett, M. J. Walker, Imamura A., Ishida H., Ikebe T., Miyamoto T., Ato M., Ohga S., B. Lepenies, N. M. van Sorge, Yamasaki S. Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10662-E10671. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering, Research Promotion Unit / Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University）
3. Gotoh K, Morisaki T, Setoyama D, Sasaki K, Yagi M, Igami K, Mizuguchi S, Uchiumi T, Fukui Y, Kang D. Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation. Cell Rep. 2018 Nov 13;25(7):1800-1815.e4. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Electron Microscopes) / Clinical Chemistry and Laboratory Medicine, School of Medicine, Kyushu University）
4. Sakakibara Y., Nagao K., Blewitt M., Sasaki H., Obuse C., Sado T. Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice. Development. 2018 Sep 25;145(18). [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (DNA Sequencing) / Division of Epigenomics and Development）
5. Fujii T, Yamasaki R, Iinuma K, Tsuchimoto D, Hayashi Y, Saitoh BY, Matsushita T, Kido MA, Aishima S, Nakanishi H, Nakabeppu Y, Kira JI. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. Ann Neurol. 2018 Aug;84(2):208-224. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Proteome Analysis) / Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University / Division of Neurofunctional Genomics）
6. Nakayama S, Yumimoto K, Kawamura A, Nakayama KI. Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3. J Biol Chem. 2018 Apr 13;293(15):5705-5714. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit / Division of Cell Biology）
7. Koshiyama T, Tanaka M, Honjo M, Fukunaga Y, Okamura T, Ohba M. Direct Synthesis of Prussian Blue Nanoparticles in Liposomes Incorporating Natural Ion Channels for Cs+ Adsorption and Particle Size Control.Langmuir. 2018 Jan 30;34(4):1666-1672. [PubMed]
   （Laboratory for Research Support, Research Promotion Unit (Electron Microscopes) / Department of Chemistry, Graduate School of Science, Kyushu University）

2017（19)

1. Muto Y., Nishiyama M., Nita A., Moroishi T. Nakayama KI.　Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.　Nature Commun.8: 16114, 2017. [PubMed]
   （Laboratory for Research Support (Microarray) / Division of Cell Biology）
2. Yaguchi H., Yabe I., Takahashi H., Watanabe M., Nomura T., Kano T., Matsumoto M., Nakayama KI., Watanabe M., Hatakeyama S. Sez6l2 regulates phosphorylation of ADD and neuritogenesis. Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):234-241. [PubMed]
   （Laboratory for Research Support (Proteome Analysis) / Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University «Joint Usage/Research Center»）
3. Nakatsumi H., Matsumoto M., Nakayama KI. Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages. Cell Rep. 2017 Nov 28;21(9):2471-2486. [PubMed]
   （Laboratory for Research Support (Proteome Analysis, DNA Sequencing, Microarray) / Division of Cell Biology）
4. Fujinami D., Taguchi Y., Kohda D. Asn-linked oligosaccharide chain of a crenarchaeon, Pyrobaculum calidifontis, is reminiscent of the eukaryotic high-mannose-type glycan. Glycobiology. 2017 May 16. [PubMed]
   （Laboratory for Research Support (Proteome Analysis) / Division of Structural Biology）
5. Miura S., Suzuki A. Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming. Cell Stem Cell. 2017 Oct 5;21(4):456-471.e5. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation) / Division of Organogenesis and Regeneration）
6. Yamazaki S, Tanaka Y, Araki H, Kohda A, Sanematsu F, Arasaki T, Duan X, Miura F, Katagiri T, Shindo R, NakanoH, Ito T, Fukui Y, Endo S, Sumimoto H. The AP-1 transcription factor JunB is required for Th17 cell differentiation. Sci Rep. 2017 Dec 12;7(1):17402. [PubMed]
   （Laboratory for Research Support / Department of Biochemistry, Graduate School of Medical Sciences, Kyushu University ）
7. Yanagihara T., Tomino T., Uruno T., Fukui Y. Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein expression and exacerbates disease development in a mouse model of autoimmune diabetes. Biochem Biophys Res Commun. 2017 Jul 15;489(1):8-13. [PubMed]
   （Laboratory for Research Support / Division of Immunogenetics）
8. Fujii T., YamasakiR., Iinuma K., Tsuchimoto D., Hayashi Y., Saitoh B., Matsushita T., Kido M. A., Aishima S., Nakanishi H., Nakabeppu Y., Kira JI. A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain. Ann Neurol. 2018 Aug;84(2):208-224. [PubMed]
   （Laboratory for Research Support (Proteome Analysis) / Department of Neurology Neurological Institute, Graduate School of Medicine, Kyushu University / Division of Neurofunctional Genomics）
9. E. Castillo, J. Leon, G. Mazzei, N. Abolhassani, Haruyama N., Saito T., Saido T., Hokama M., Iwaki T., Ohara T., Ninomiya T., Kiyohara Y., Sakumi K., F. M. LaFerla, Nakabeppu Y. Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Scientific Reportsvolume 7, Article number: 17762 (2017) [PubMed]
   （Laboratory for Research Support (Microarray) / Division of Neurofunctional Genomics）
10. Shibata T, Hadano J, Kawasaki D, Dong X, Kawabata SI. Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations. J. Biol. Chem. 2017 Jun 23;292(25):10723-10734. [PubMed]
    （Laboratory for Research Support (Electron Microscopes) / Protein Science and Cellular Biochemistry, Faculty of Science, Kyushu University）
11. Kabayama Y, Toh H, Katanaya A, Sakurai T, Chuma S, Kuramochi-Miyagawa S, Saga Y, Nakano T, Sasaki H. Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes. Nucleic Acids Res. 2017 May 19;45(9):5387-5398. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Epigenomics and Development / Division of Epigenomics）
12. Matsumoto S, Taguchi Y, Shimada A, Igura M, Kohda D. Tethering an N-Glycosylation Sequon-Containing Peptide Creates a Catalytically Competent Oligosaccharyltransferase Complex. Biochemistry. 2017 Jan 31;56(4):602-611. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Division of Structural Biology）
13. Nagata M, Izumi Y, Ishikawa E, Kiyotake R, Doi R, Iwai S, Omahdi Z, Yamaji T, Miyamoto T, Bamba T, Yamasaki S. Intracellular metabolite β-glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3285-E3294. [PubMed]
    （Laboratory of Embryonic and Genetic Engineering / Division of Molecular Immunology / Division of Metabolomics）
14. Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama KI. FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017 Mar 31;37(8). [PubMed]
    （Laboratory for Research Support (DNA Sequencing, Pathological specimen preparation) / Division of Cell Biology）
15. Matsumoto M, Matsuzaki F, Oshikawa K, Goshima N, Mori M, Kawamura Y, Ogawa K, Fukuda E, Nakatsumi H, Natsume T, Fukui K, Horimoto K, Nagashima T, Funayama R, Nakayama K, Nakayama KI. A large-scale targeted proteomics assay resource based on an in vitro human proteome. Nat Methods. 2017 Mar;14(3):251-258. [PubMed]
    （Laboratory for Research Support (Proteomics Analysis) / Division of Cell Biology / Division of Proteomics）
16. Matsumoto S, Taguchi Y, Shimada A, Igura M, Kohda D. Tethering an N-Glycosylation Sequon-Containing Peptide Creates a Catalytically Competent Oligosaccharyltransferase Complex. Biochemistry. 2017 Jan 31;56(4):602-611. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Division of Structural Biology）
17. Ohnishi T, Shirane M, Nakayama KI. SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth. Sci Rep. 2017 Jan 20;7:41130. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Division of Cell Biology）
18. Mori D, Shibata K, Yamasaki S. C-Type Lectin Receptor Dectin-2 Binds to an Endogenous Protein β-Glucuronidase on Dendritic Cells. PLoS One. 2017 Jan 3;12(1):e0169562. [PubMed]
    （Laboratory for Research Support (Proteome Analysis, DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular Immunology）
19. Nakaya M, Watari K, Tajima M, Nakaya T, Matsuda S, Ohara H, Nishihara H, Yamaguchi H, Hashimoto A, Nishida M, Nagasaka A, Horii Y, Ono H, Iribe G, Inoue R, Tsuda M, Inoue K, Tanaka A, Kuroda M, Nagata S, Kurose H. Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction. J Clin Invest. 2017 Jan 3;127(1):383-401. [PubMed]
    （Laboratory for Research Support (Electron Microscopes, Pathological specimen preparation) / Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University）

2016（15)

1. Kanemura, S., Okumura, M., Yutani, K., Ramming, T., Hikima, T., Appenzeller-Herzog, C., Akiyama, S., and Inaba, K. Human ER Oxidereductin-1a (Ero1a) undergoes dual regulation through complementary redox interactions with Protein Disulfide Isomerase. J. Biol. Chem. 2016 Nov 11;291(46):23952-23964. [PubMed]
   （Laboratory for Research Support (Proteome Analysis) / Institute of Multidisciplinary Research for Advanced Materials, Tohoku University «Joint Usage/Research Center»）
2. Toyonaga K, Torigoe S, Motomura Y, Kamichi T, Hayashi JM, Morita YS, Noguchi N, Chuma Y, Kiyohara H, Matsuo K, Tanaka H, Nakagawa Y, Sakuma T, Ohmuraya M, Yamamoto T, Umemura M, Matsuzaki G, Yoshikai Y, Yano I, Miyamoto T, Yamasaki S. C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection.Immunity. 2016 Dec 20;45(6):1245-1257. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Molecular Immunology / Division of Host Defense）
3. Sekiya S, Miura S, Matsuda-Ito K, Suzuki A. Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment. Stem Cell Reports. 2016 Dec 13;7(6):1130-1139. [PubMed]
   （Laboratory for Research Support, Laboratory of Embryonic and Genetic Engineering/Laboratory of Embryonic and Genetic Engineering (Pathological specimen preparation) / Division of Organogenesis and Regeneration）
4. Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S. The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. J Mol Cell Cardiol. 2016 Nov;100:43-53. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis) / Hokkaido University «Joint Usage/Research Center» / Division of Cell Biology）
5. Oka S, Leon J, Sakumi K, Ide T, Kang D, LaFerla FM, Nakabeppu Y. Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease. Sci Rep. 2016 Nov 29;6:37889. [PubMed]
   （Laboratory for Research Support (Microarray) / Division of Neurofunctional Genomics）
6. Terada M, Horisawa K, Miura S, Takashima Y, Ohkawa Y, Sekiya S, Matsuda-Ito K, Suzuki A. Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma. Sci Rep. 2016 Oct 4;6:34691. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering / Division of Organogenesis and Regeneration）
7. Katayama Y, Nishiyama M, Shoji H, Ohkawa Y, Kawamura A, Sato T, Suyama M, Takumi T, Miyakawa T, Nakayama KI. CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Nature. 2016 Sep 29;537(7622):675-679. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology / Division of Transcriptomics / Division of Bioinformatics）
8. Ishikawa E, Kosako H, Yasuda T, Ohmuraya M, Araki K, Kurosaki T, Saito T, Yamasaki S. Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat Commun. 2016 Sep 27;7:12756. [PubMed]
   （Laboratory for Research Support (Mass Spectrum Measurement) / Division of Molecular Immunology）
9. Li Y, Kobayashi K, Mona MM, Satomi C, Okano S, Inoue H, Tani K, Takahashi A. Immunogenic FEAT protein circulates in the bloodstream of cancer patients. J. Transl. Med. 2016 Sep 22;14(1):275. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Molecular Design）
10. Yoneshima Y, Abolhassani N, Iyama T, Sakumi K, Shiomi N, Mori M, Shiomi T, Noda T, Tsuchimoto D, Nakabeppu Y. Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells. Sci Rep. 2016 Sep 13;6:32849. [PubMed]
    （Laboratory for Research Support (DNA Sequencing, Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering / Division of Neurofunctional Genomics）
11. Nii T, Kohara H, Marumoto T, Sakuma T, Yamamoto T, Tani K. Single-Cell-State Culture of Human Pluripotent Stem Cells Increases Transfection Efficiency. Biores Open Access. 2016 May 1;5(1):127-36. [PubMed]
    （Laboratory for Research Support / Division of Molecular Design）
12. Hosokawa H, Tanaka T, Endo Y, Kato M, Shinoda K, Suzuki A, Motohashi S, Matsumoto M, Nakayama KI, Nakayama T. Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells. Nat Commun. 2016 Apr 7;7:11289. [PubMed]
    （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement, DNA Sequencing) / Chiba University «Joint Usage/Research Center» / Division of Cell Biology）
13. Tanaka M, Shiota M, Nakao T, Uemura R, Nishi S, Ohkawa Y, Matsumoto M, Yamaguchi M, Osada-Oka M, Inagaki A, Takahashi K, Nakayama KI, Gi M, Izumi Y, Miura K, Iwao H. Identification of low-abundance proteins in serum via the isolation of HSP72 complexes. J. Proteomics. 2016 Mar 16;136:214-21. [PubMed]
    （Laboratory for Research Support (Proteome Analysis) / Osaka City University «Joint Usage/Research Center» / Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University / Division of Cell Biology）
14. Shinoda K, Sun X, Oyamada A, Yamada H, Kira J, Yoshikai Y. Requirement of CD30 expression on CD4 T cells in the pathogenesis of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2016 Feb 15;291:39-45. [PubMed]
    （Laboratory for Research Support (Pathological specimen preparation) / Division of Host Defense）
15. Fujimoto N, Kan-O M, Ushijima T, Kage Y, Tominaga R, Sumimoto H, Takeya R. Transgenic Expression of the Formin Protein Fhod3 Selectively in the Embryonic Heart: Role of Actin-Binding Activity of Fhod3 and Its Sarcomeric Localization during Myofibrillogenesis. PLoS. One. 2016 Feb 5;11(2):e0148472. [PubMed]
    （Laboratory for Research Support (Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering / Departments of Biochemistry, Graduate School of Medical Sciences, Kyushu University）

2015（13)

1. Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y, Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Yoshinori F. Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus. Nat Commun. 2015 Nov 4;6:8820. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation, Proteome Analysis) / Division of Immunogenetics / Division of Bioinformatics）
2. Nishiyama M, Nita A, Yumimoto K, Nakayama KI. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Stem Cells. 2015 Nov;33(11):3327-40. [PubMed]
   （Laboratory for Research Support (Proteome Analysis, Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
3. Kiyotake R, Oh-Hora M, Ishikawa E, Miyamoto T, Ishibashi T, Yamasaki S. Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses. J Biol Chem. 2015 Oct 16;290(42):25322-32. [PubMed]
   （Laboratory for Research Support (DNA Sequencing, Microarray) / Division of Molecular Immunology）
4. Watanabe K, Yumimoto K, Nakayama KI. FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1. Genes Cells. 2015 Aug;20(8):667-74. [PubMed]
   （Laboratory for Research Support (Proteome Analysis) / Division of Cell Biology）
5. Kazumitsu Maehara, Akihito Harada, Yuko Sato, Masaki Matsumoto, Keiichi I. Nakayama, Hiroshi Kimura, and Yasuyuki Ohkawa. Tissue-specific expression of histone H3 variants diversified after species separation. Epigenetics Chromatin. 2015; 8: 35. [PubMed]
   （Laboratory for Research Support (Proteome Analysis) / Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University / Division of Cell Biology）
6. Miyake Y, Masatsugu OH, Yamasaki S. C-Type Lectin Receptor MCL Facilitates Mincle Expression and Signaling through Complex Formation. J Immunol. 2015 Jun 1;194(11):5366-74. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Molecular Immunology）
7. Motomura Y, Kanno S, Asano K, Tanaka M, Hasegawa Y, Katagiri H, Saito T, Hara H, Nishio H, Hara T, Yamasaki S. Identification of Pathogenic Cardiac CD11c+ Macrophages in Nod1-Mediated Acute Coronary Arteritis. Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1423-33. [PubMed]
   （Laboratory for Research Support (Electron Microscopes, Microarray) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular Immunology）
8. Murata M, Piao JS, Narahara S, Kawano T, Hamano N, Kang JH, Asai D, Ugawa R, Hashizume M. Expression and characterization of myristoylated preS1-conjugated nanocages for targeted cell delivery. Protein Expr Purif. 2015 Jun;110:52-6. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Disaster and Emergency medicine, Faculty of Medical Sciences, Kyushu University）
9. Hosokawa H, Kato M, Tohyama H, Tamaki Y, Endo Y, Kimura M.Y, Tumes D.J, Motohashi S, Matsumoto M, Nakayama K.I, Tanaka T, Nakayama T. Methylation of Gata3 Protein at Arg-261 Regulates Transactivation of the Il5 Gene in T Helper 2 Cells. J Biol Chem. 2015 May 22; 290(21): 13095-13103. [PubMed]
   （Laboratory for Research Support (Proteome Analysis, DNA Sequencing) / Chiba University «Joint Usage/Research Center» / Division of Cell Biology）
10. Yoshida Y, Niwa H, Honsho M, Itoyama A, Fujiki Y. Pex11mediates peroxisomal proliferation by promoting deformation of the lipid membrane. Biol Open. 2015 Apr 24;4(6):710-21. [PubMed]
    （Laboratory for Research Support (Electron Microscopes) / Department of Biology, Faculty of Science, Kyushu University）
11. Shinoda K, Sun X, Oyamada A, Yamada H, Muta H, Podack ER, Kira J, Yoshikai Y. CD30 ligand is a new therapeutic target for central nervous system autoimmunity. J Autoimmun. 2015 Feb;57:14-23. [PubMed]
    （Laboratory for Research Support (Pathological specimen preparation) / Division of Host Defense）
12. Kobayakawa Y, Sakumi K, Kajitani K, Kadoya T, Horie H, Kira JI, Nakabeppu Y. Galectin-1 deficiency improves axonal swelling of motor neurons in SOD1G93A transgenic mice. Neuropathol Appl Neurobiol. 2015 Feb;41(2):227-44. [PubMed]
    （Laboratory for Research Support (Electron Microscopes, Pathological specimen preparation) / Division of Neurofunctional Genomics）
13. Yumimoto K, Akiyoshi S, Ueo H, Sagara Y, Onoyama I, Ueo H, Ohno S, Mori M, Mimori K, Nakayama KI.　F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner. J Clin Invest. 2015 Feb;125(2):621-35. [PubMed]
    （Laboratory for Research Support (Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）

2014（12)

1. Hokama M., Oka S., J. Leon, Ninomiya T., Honda H., Sasaki K., Iwaki T., Ohara T., Sasaki T., F. M. LaFerla, Kiyohara Y., Nakabeppu Y. Altered expression of diabetes-related genes in Alzheimer’s disease brains: The Hisayama study. Cereb Cortex 24(9):2476-88.2014. [PubMed]
   （Laboratory for Research Support (Microarray) / Division of Neurofunctional Genomics）
2. Toyonaga K, Miyake Y2, Yamasaki S2. Characterization of the receptors for mycobacterial cord factor in Guinea pig. PLoS One. 9(2):e88747. 2014. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Molecular Immunology）
3. Moroishi T, Yamauchi T, Nishiyama M, Nakayama KI. HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism. J Biol Chem. 289(23):16430-41. 2014. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Division of Cell Biology）
4. Nomaru H, Sakumi K, Katogi A, Ohnishi YN, Kajitani K, Tsuchimoto D, Nestler EJ, Nakabeppu Y. Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. Glia. 62(8):1284-98.2014. [PubMed]
   （Laboratory for Research Support (Microarray, DNA Sequencing) / Division of Neurofunctional Genomics）
5. Matsumoto A, Takeishi S, Nakayama KI. p57 regulates T cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling. Blood. 123(22):3429-39. 2014. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
6. Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, Sanematsu F, Yamamura K, Terasawa M, Nishikimi A, Jean-François Côté, Fukui Y. DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation. J. Exp. Med. 211(7):1407-19.2014. [PubMed]
   （Laboratory for Research Support (Pathological Specimen Creation) / Laboratory of Embryonic and Genetic Engineering / Division of Immunogenetics）
7. Shinoda K, Sun X, Oyamada A, Yamada H, Muta H, Podack ER, Kira JI, Yoshikai Y. CD30 ligand is a new therapeutic target for central nervous system autoimmunity. J Autoimmun. 2014 Dec 18. pii: S0896-8411(14)00169-3. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation) / Division of Host Defense）
8. Yamauchi T, Nishiyama M, Moroishi T, Yumimoto K, Nakayama KI. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. Mol Cell Biol. 34(17):3321-40. 2014. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Division of Cell Biology）
9. Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T. Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Cell Rep. 8(5):1391-404. 2014. [PubMed]
   （Laboratory for Research Support / Division of Cell Regulation Systems）
10. Yonekawa A, Saijo S, Hoshino Y, Miyake Y, Ishikawa E, Suzukawa M, Inoue H, Tanaka M, Yoneyama M, Oh-Hora M, Akashi K, Yamasaki S.　Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria. Immunity. 41(3):402-13. 2014. [PubMed]
    （Laboratory for Research Support / Division of Molecular Immunology）
11. Sekiya S. and Suzuki A. Hepatocytes, rather than cholangiocytes, can be the major source of primitive ductules in the chronically injured mouse liver. Am J Pathol. 184(5):1468-78. 2014. [PubMed]
    （Laboratory of Embryonic and Genetic Engineering / Division of Organogenesis and Regeneration）
12. Yamaguchi S, Marumoto T, Nii T, Kawano H, Liao J, Nagai Y, Okada M, Takahashi A, Inoue H, Sasaki E, Fujii H, Okano S, Ebise H, Sato T, Suyama M, Okano H, Miura Y, Tani K. Characterization of common marmoset dysgerminoma-like tumor induced by the lentiviral expression of reprogramming factors. Cancer Sci. 105(4):402-8. 2014. [PubMed]
    （Laboratory for Research Support (Pathological specimen preparation) / Division of Molecular and Clinical Genetics / Division of Bioinformatics）

2013（10)

1. Ishikawa T, Itoh F, Yoshida S, Saijo S, Matsuzawa T, Gonoi T, Saito T, Okawa Y, Shibata N, Miyamoto T, Yamasaki S. Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic Fungus Malassezia. Cell Host Microbe. 2013 Apr 17;13(4):477-88. [PubMed]
   （«Joint Usage/Research Center» / Division of Molecular Immunology）
2. Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Naoki Takeda, Chika Sakamoto, Hirotaka Kawano, Takenobu Nii, Shohei Miyamato, Yoko Nagai, Michiyo Okada, Hiroyuki Inoue, Kohichi Kawahara, Akira Suzuki, Yoshie Miura, and Kenzaburo Tani.　Inhibition of PTEN Tumor Suppressor Promotes the Generation of Induced Pluripotent Stem Cells. Mol Ther. 2013 Jun; 21(6): 1242-1250. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Clinical Genetics / Division of Cancer Genetics）
3. Saita S.,Shirane M., Nakayama K.(2013) Selective escape of proteins from the mitochondria during mitophagy. Nat. Commun. 4(1410): 1-14. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Cell Biology）
4. Yumimoto K., Matsumoto M., Onoyama I., Imaizumi K., Nakayama KI.(2013) F-box and WD repeat domain containing-7 (Fbxw7) targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. J. Biol. Chem.288: 28488-502. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Division of Cell Biology）
5. Matsumoto S., Shimada A., Kohda D. (2013) Crystal structure of the C-terminal globular domain of the third paralog of the Archaeoglobus fulgidus oligosaccharyltransferases.BMC Struct. Biol.13:11. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Structural Biology）
6. Matsumoto S., Shimada A., J. Nyirenda, Igura M., Kawano Y., Kohda D. (2013) Crystal structures of an archaeal oligosaccharyltransferase provide insights into the catalytic cycle of N-linked protein glycosylation.PNAS110(44): 17868-17873. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Structural Biology）
7. Kamakura S, Nomura M, Hayase J, Iwakiri Y, Nishikimi A, Takayanagi R, Fukui Y, Sumimoto H. The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway. Dev Cell. 26(3):292-302.2013. [PubMed]
   （Laboratory for Research Support / Departments of Biochemistry, Graduate School of Medical Sciences, Kyushu University）
8. Miyake Y, Toyonaga K, Mori D, Kakuta S, Hoshino Y, Oyamada A, Yamada H, Ono K, Suyama M, Iwakura Y, Yoshikai Y, Yamasaki S. C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity. 38(5):1050-62.2013. [PubMed]
   （Laboratory for Research Support / Division of Molecular Immunology / Division of Host Defense / Division of Bioinformatics）
9. Yamamoto A, Takeya R, Matsumoto M, Nakayama KI, Sumimoto H. Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1. FEBS J. 280(20):5145-59. 2013. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Departments of Biochemistry, Graduate School of Medical Sciences, Kyushu University / Division of Cell Biology）
10. Ishibashi M, Kogo R, Shibata K, Ueo H, Uchi R, Matsumura T, Takano Y, Sawada G, Takahashi Y, Mima K, Kurashige J, Akiyoshi S, Iwaya T, Eguchi H, Sudo T, Sugimachi K, Suzuki A, Wakabayashi G, Mori M, Mimori K. Clinical significance of PICT1 in patients of hepatocellular carcinoma with wild-type TP53. Ann Surg Oncol. 20 Suppl 3:S537-44. 2013. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Department of Surgery, Kyushu University Beppu Hospital）

2012（12)

1. Sekiya S, Suzuki A. Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J Clin Invest. 2012 Nov 1;122(11):3914-8. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Organogenesis and Regeneration）
2. Tateishi Y, Matsumoto A, Kanie T, Hara E, Nakayama K, Nakayama KI. Development of mice without Cip/Kip CDK inhibitors. Biochem Biophys Res Commun. 2012 Oct 19;427(2):285-92. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
3. Z. Sheng, Oka S., Tsuchimoto D., N. Abolhassani, Nomaru H., Sakumi K., Yamada H., Nakabeppu Y.(2012) 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA bese excision repair.J. Clin. Invest. 122(12): 4344-4361. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Neurofunctional Genomics）
4. Kan-o M., Takeya R., Abe T., Kitajima N., Nishida M., Tominaga R., Kurose H., Sumimoto H.(2012) Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis. Biology Open 1: 889-896. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation, Electron Microscopes) / Department of Biochemistry, Graduate School of Medical Sciences, Kyushu University）
5. Ota S., Ishitani S., Shimizu N., Matsumoto K., Itoh M., Ishitani T.(2012) NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J. 31(8): 1904-1915. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation) / Division of Cell Regulation Systems）
6. Yumimoto K., Matsumoto M., Oyamada K., Moroishi T., and Nakayama KI. (2012) Comprehensive Identification of Substrates for F-box Proteins by Differential Proteomics Analysis. J. Proteome Res. 11: 3175-3185. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Division of Cell Biology）
7. Oshikawa K., Matsumoto M., Oyamada K., Nakayama KI. (2012) Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. J. Proteome Res. 11: 796-807. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Division of Cell Biology）
8. D. Murata, K. H. Nomura, K. Dejima, S. Mizuguchi, N. Kawasaki, Y. Matsuishi-Nakajima, S. Ito, K. Gengyo-ando, E. Kage-nakadai, S. Mitani, and K. Nomura(2012) GPI-anchor synthesis is indispensable for the germline development of the nematode Caenorhabditis elegans. Mol. Biol. Cell 23(6): 982-995. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Developmental Biology, Faculty of Science, Kyushu University）
9. Iwashita Y., Fukuchi N., Waki M., Hayashi K., and Tahira T.(2012) Genome-wide Repression of NF-κB Target Genes by Transcription Factor MIBP1 and Its Modulation by O-Linked β-N-Acetylglucosamine(O-GlcNAc) Transferase.J. Biol. Chem. 287(13): 9887-9900. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement, Microarray) / Division of Genome Analysis）
10. Shimizu N, Kawakami K, Ishitani T. Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish. Dev Biol. 370(1):71-85.2012. [PubMed]
    （Laboratory for Research Support / Division of Cell Regulation Systems）
11. Matsumoto S, Igura M, Nyirenda J, Matsumoto M, Yuzawa S, Noda N, Inagaki F, Kohda D. Crystal structure of the C-terminal globular domain of oligosaccharyltransferase from Archaeoglobus fulgidus at 1.75 Å resolution. Biochemistry. 51(20):4157-66. 2012. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Division of Structural Biology）
12. Kan-o M, Takeya R, Taniguchi K, Tanoue Y, Tominaga R, Sumimoto H. Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart. PLoS One. 7(4):e34765.2012. [PubMed]
    （Laboratory for Research Support (Electron Microscopes) / Laboratory of Embryonic and Genetic Engineering / Departments of Biochemistry, Graduate School of Medical Sciences, Kyushu University）

2011（11)

1. Matsuzaki F., Shirane M., Matsumoto M., and Nakayama K.(2011) Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.Mol. Biol. Cell 22: 4602-4620. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement, DNA Sequencing, Deltavision) / Division of Cell Biology）
2. Moroishi T., Nishiyama M., Takeda Y., Iwai K., Nakayama K.(2011) The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo.Cell Metab. 14: 339-351. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement, Pathological specimen preparation, Electron Microscopes) / Division of Cell Biology）
3. Iwama E., Tsuchimoto D., Iyama T., Sakumi K., Nakagawara A., Takayama K., Nakanishi Y., Nakabeppu Y.(2011) Cancer-Related PRUNE2 Protein Is Associated with Nucleotides and Is Highly Expressed in Mature Nerve Tissues.J. Mol. Nucreosci. 44: 103-114. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement, DNA Sequencing) / Division of Neurofunctional Genomics）
4. Matsumoto A, Susaki E, Onoyama I, Nakayama K, Hoshino M, Nakayama KI. Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice. Mol Cell Biol. 2011 Oct;31(20):4176-92. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
5. Fuchiwaki T, Sun X, Fujimura K, Yamada H, Shibata K, Muta H, Podack ER, Kawauchi H, Yoshikai Y. The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice. Eur J Immunol. 2011 Oct;41(10):2947-54. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation) / Division of Host Defense）
6. Ohnishi YN, Ohnishi YH, Hokama M, Nomaru H, Yamazaki K, Tominaga Y, Sakumi K, Nestler EJ, Nakabeppu Y. FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB.　Biol Psychiatry. 2011 Sep 1;70(5):487-95. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Neurofunctional Genomics）
7. Matsumoto A, Takeishi S, Kanie T, Susaki E, Onoyama I, Tateishi Y, Nakayama K, Nakayama KI. p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2011 Sep 2;9(3):262-71. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
8. Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama KI. Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells. J Biol Chem. 2011 Apr 15;286(15):13754-64. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
9. Matsumoto A, Tateishi Y, Onoyama I, Okita Y, Nakayama K, Nakayama KI. Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress. Cancer Sci. 2011 Apr;102(4):749-55. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
10. Nakaya M, Hamano S, Kawasumi M, Yoshida H, Yoshimura A, Kobayashi T. Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations. Int Immunol. 2011 Mar;23(3):195-202. [PubMed]
    （Laboratory for Research Support (DNA Sequencing, Pathological specimen preparation) / Division of Molecular and Cellular Immunology）
11. Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI. Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.J Clin Invest. 2011 Jan;121(1):342-54. [PubMed]
    （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology / Division of Organogenesis and Regeneration）

2010（8)

1. Okamoto F, Saeki K, Sumimoto H, Yamasaki S, Yokomizo T. Leukotriene B4 augments and restores Fc gammaRs-dependent phagocytosis in macrophages. J Biol Chem. 2010 Dec 24;285(52):41113-21. [PubMed]
   （Laboratory for Research Support (DNA Sequencing, Mass Spectrum Measurement) / Department of Medical Biochemistry, Faculty of Medical Sciences, Kyushu University / Departments of Biochemistry, Graduate School of Medical Sciences, Kyushu University / Division of Molecular Immunology）
2. Ishikawa E., Miyake Y., Hara H., Saito T., Yamasaki S.(2010) Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for β-selection and TCR repertoire formation.Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19979-84. [PubMed]
   （Laboratory for Research Support / Division of Molecular Immunology）
3. Iyama T., N. Abolhassani, Tsuchimoto D., Nonaka M., Nakabeppu Y. NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuculear DNA and growth arrest.Nucleic Acids Res, 2010 Aug;38(14):4834-43. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement, DNA Sequencing) / Division of Neurofunctional Genomics）
4. N. Abolhassani, Iyama T., Tsuchimoto D., Sakumi K., Ohono M., M. Behmanesh, Nakabeppu Y. NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals.Nucleic Acids Res, 2010 May;38(9):2891-903. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Neurofunctional Genomics）
5. Susaki E, Kaneko-Oshikawa C, Miyata K, Tabata M, Yamada T, Oike Y, Katagiri H, Nakayama KI. Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. J Biol Chem. 2010 May 14;285(20):15538-47. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
6. Minakami R, Maehara Y, Kamakura S, Kumano O, Miyano K, Sumimoto H. Membrane phospholipid metabolism during phagocytosis in human neutrophils. Genes Cells. 2010 May;15(5):409-24. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Departments of Biochemistry, Graduate School of Medical Sciences, Kyushu University）
7. Maita N, Nyirenda J, Igura M, Kamishikiryo J, Kohda D. Comparative structural biology of eubacterial and archaeal oligosaccharyltransferases. J Biol Chem. 2010 Feb 12;285(7):4941-50. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Structural Biology）
8. Matsuda T, Takahashi-Yanaga F, Yoshihara T, Maenaka K, Watanabe Y, Miwa Y, Morimoto S, Kubohara Y, Hirata M, Sasaguri T. Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity. J Pharmacol Sci. 112(3):320-6.2010. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University）

2009（15)

1. Ishikawa E, Ishikawa T, Morita Y S, Toyonaga K, Yamada H, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.J Exp Med. 2009 Dec 21;206(13):2879-88. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular Immunology）
2. Behmanesh M, Sakumi K, Abolhassani N, Toyokuni S, Oka S, Ohnishi YN, Tsuchimoto D, Nakabeppu Y. ITPase-deficient mice show growth retardation and die before weaning. Cell Death Differ. 2009 Oct;16(10):1315-22. [PubMed]
   （Laboratory for Research Support (Electron Microscopes, DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Neurofunctional Genomics）
3. Taniguchi K, Takeya R, Suetsugu S, Kan-o M, Narusawa M, Shiose A, Tominaga R, Sumimoto H. Mammalian Formin Fhod3 Regulates Actin Assembly and Sarcomere Organization in Striated Muscles.　J Biol Chem. 2009 Oct 23;284(43):29873-81. [PubMed]
   （Laboratory for Research Support (Electron Microscopes, DNA Sequencing) / Division of Cell Biology）
4. Sasaki K, Kajikawa M, Kuroki K, Motohashi T, Shimojima T, Park EY, Kondo S, Yagi H, Kato K, Maenaka K. Silkworm expression and sugar profiling of human immune cell surface receptor, KIR2DL1. Biochem Biophys Res Commun. 2009 Sep 25;387(3):575-80. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Structural Biology）
5. Matsumoto M, Oyamada K, Takahashi H, Sato T, Hatakeyama S, Nakayama KI. Large-scale proteomic analysis of tyrosine-phosphorelation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways. Proteomics. 2009 Jul;9(13):3549-63. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Division of Cell Biology）
6. Saiga T, Fukuda T, Matsumoto M, Tada H, Okano HO, Okano H, Nakayama KI. Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development. Mol Cell Biol. 2009 Jul;29(13):3529-43. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
7. Ichiyama K, Hashimoto M, Sekiya T, Nakagawa R, Wakabayashi Y, Sugiyama Y, Komai K, Saba I, Möröy T, Yoshimura A. Gfi1 negatively regulates T(h)17 differentiation by inhibiting RORgammat activity. Int Immunol. 2009 Jul;21(7):881-9. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Keio University School of Medicine）
8. Saeki K, Fukuyama S, Ayada T, Nakaya M, Aki D, Takaesu G, Hanada T, Matsumura Y, Kobayashi T, Nakagawa R, Yoshimura A. A Major Lipid Raft Protein Raftlin Modulates T Cell Receptor Signaling and Enhances Th17-Mediated Autoimmune Responses. J Immunol. 2009 May 15;182(10):5929-37. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）
9. Yoshimura T, Sonoda KH, Ohguro N, Ohsugi Y, Ishibashi T, Cua DJ, Kobayashi T, Yoshida H, Yoshimura A. Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatology (Oxford). 2009 Apr;48(4):347-54. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Molecular and Cellular Immunology）
10. Minoda Y, Sakurai H, Kobayashi T, Yoshimura A, Takaesu G. An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. Biochem Biophys Res Commun. 2009 Apr 10;381(3):412-7. [PubMed]
    （Laboratory for Research Support (DNA Sequencing, Mass Spectrum Measurement) / Division of Molecular and Cellular Immunology）
11. Nonaka M, Tsuchimoto D, Sakumi K, Nakabeppu Y. Mouse RS21-C6 is a mammalian 2'-deoxycytidine 5'-triphosphate pyrophosphohydrolase that prefers 5-iodocytosine. FEBS J. 2009 Mar;276(6):1654-66. [PubMed]
    （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement, DNA Sequencing) / Division of Neurofunctional Genomics）
12. Susaki E, Nakayama K, Yamasaki L, Nakayama KI. Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5192-7. [PubMed]
    （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
13. Koga K, Takaesu G, Yoshida R, Nakaya M, Kobayashi T, Kinjyo I, Yoshimura A. Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein. Immunity. 2009 Mar 20;30(3):372-83. [PubMed]
    （Laboratory for Research Support (DNA Sequencing, Microarray) / Division of Molecular and Cellular Immunology）
14. Ayada T, Taniguchi K, Okamoto F, Kato R, Komune S, Takaesu G, Yoshimura A. Sprouty4 negatively regulates protein kinase C activation by inhibiting. Oncogene. 2009 Feb 26;28(8):1076-88. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Division of Molecular and Cellular Immunology）
15. Taniguchi K, Sasaki K, Watari K, Yasukawa H, Imaizumi T, Ayada T, Okamoto F, Ishizaki T, Kato R, Kohno R, Kimura H, Sato Y, Ono M, Yonemitsu Y, Yoshimura A. Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis. PLoS One. 4(5):e5467. 2009. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）

2008（19)

1. Kajikawa M, Sasaki K, Wakimoto Y, Toyooka M, Motohashi T, Shimojima T, Takeda S, Park EY, Maenaka K. Efficient silkworm expression of human GPCR (nociceptin receptor) by a Bombyx mori bacmid DNA system. Biochem Biophys Res Commun. 385(3):375-9. 2008. [PubMed]
   （Laboratory for Research Support (DNA Sequencing, Electron Microscopes) / Division of Structural Biology）
2. Sanada T, Takaesu G, Mashima R, Yoshida R, Kobayashi T, Yoshimura A. FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 283(49):33858-64. 2008. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation, DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）
3. Takaki H, Ichiyama K, Koga K, Chinen T, Takaesu G, Sugiyama Y, Kato S, Yoshimura A, Kobayashi T. STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor. J Biol Chem. 283(22):14955-62. 2008. [PubMed]
   （Laboratory for Research Support (DNA Sequencing, Electron Microscopes, Pathological specimen preparation) / Division of Molecular and Cellular Immunology）
4. Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A. Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads. J Immunol. 180(6):3746-56. 2008. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Molecular and Cellular Immunology）
5. Aki D, Minoda Y, Yoshida H, Watanabe S, Yoshida R, Takaesu G, Chinen T, Inaba T, Hikida M, Kurosaki T, Saeki K, Yoshimura A. Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells.Genes Cells. (2):199-208. 2008. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Molecular and Cellular Immunology）
6. Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T. TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway. J. Biol. Chem. 283(52):36211-20. 2008. [PubMed]
   （Laboratory for Research Support (DNA Sequencing, Microarray) / Division of Molecular and Cellular Immunology）
7. Ohnishi YN, Sakumi K, Yamazaki K, Ohnishi YH, Miura T, Tominaga Y, Nakabeppu Y. Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol. Biol. Cell. 19(11):4717-29. 2008. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Neurofunctional Genomics）
8. Ichiyama K, Yoshida H, Wakabayashi Y, Chinen T, Saeki K, Nakaya M, Takaesu G, Hori S, Yoshimura A, Kobayashi T. Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat. J. Biol. Chem. 283(25):17003-8. 2008. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Molecular and Cellular Immunology）
9. Sakae N, Yamasaki N, Kitaichi K, Fukuda T, Yamada M, Yoshikawa H, Hiranita T, Tatsumi Y, Kira J, Yamamoto T, Miyakawa T, Nakayama KI. Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Hum. Mol. Genet. 17(20):3191-203. 2008. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
10. Nishimura J, Saiga H, Sato S, Okuyama M, Kayama H, Kuwata H, Matsumoto S, Nishida T, Sawa Y, Akira S, Yoshikai Y, Yamamoto M, Takeda K. Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor. J. Immunol. 180(6):4032-9. 2008. [PubMed]
    （Laboratory of Embryonic and Genetic Engineering / Division of Host Defense / Osaka University）
11. Saiga H, Nishimura J, Kuwata H, Okuyama M, Matsumoto S, Sato S, Matsumoto M, Akira S, Yoshikai Y, Honda K, Yamamoto M, Takeda K. Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium. J. Immunol. 181(12):8521-7. 2008. [PubMed]
    （Laboratory of Embryonic and Genetic Engineering / Osaka University）
12. Shirane M, Ogawa M, Motoyama J, Nakayama KI. Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse. Genes Cells. 13(6):635-51. 2008. [PubMed]
    （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
13. Torisu T, Nakaya M, Watanabe S, Hashimoto M, Yoshida H, Chinen T, Yoshida R, Okamoto F, Hanada T, Torisu K, Takaesu G, Kobayashi T, Yasukawa H, Yoshimura A. Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis. Hepatology. 47(5):1644-54. 2008. [PubMed]
    （Laboratory for Research Support (Pathological specimen preparation, DNA Sequencing) / Division of Molecular and Cellular Immunologys）
14. Shiraishi H, Yoshida H, Saeki K, Miura Y, Watanabe S, Ishizaki T, Hashimoto M, Takaesu G, Kobayashi T, Yoshimura A. Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells. Int Immunol. 20(9):1219-29. 2008. [PubMed]
    （Laboratory for Research Support (Pathological specimen preparation, DNA Sequencing) / Division of Molecular and Cellular Immunology）
15. Yamamoto S., Tanaka K., Sakimura R., Okada T., Nakamura T., Li Y., Takasaki M., Nakabeppu Y., Iwamoto Y.(2008) Suberoylanilide hidroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines. Anticancer Res. 28: 1585－1592. [PubMed]
    （Laboratory for Research Support (Electron Microscopes) / Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University / Division of Neurofunctional Genomics）
16. Oka S., Ohno M., Tsuchimoto D., Sakumi K., Furuichi M., Nakabeppu Y. (2008) Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs. EMBO J. 27: 421－432. [PubMed]
    （Laboratory for Research Support (Electron Microscopes, DNA Sequencing) / Division of Neurofunctional Genomics）
17. Ichikawa J., Tsuchimoto D., Oka S., Ohno M., Furuichi M., Sakumi K., Nakabeppu Y.(2008) Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death. DNA Repair 7: 418-130. [PubMed]
    （Laboratory for Research Support (Electron Microscopes, DNA Sequencing) / Division of Neurofunctional Genomics）
18. Takeya R., Taniguchi K., Narumiya S., Sumimoto H.(2008) The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells. EMBO J. 27: 618-628. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Division of Cell Biology）
19. Igura M., Maita N., Kamishikiryo J., Yamada M., Obita T., Maenaka K., Kohda D.(2008) Structure-guided identification of a new catalytic motif of oligosaccharyltransferase. EMBO J. 27: 234-243. [PubMed]
    （Laboratory for Research Support (Electron Microscopes) / Division of Structural Biology）

2007（9)

1. Torisu T, Sato N, Yoshiga D, Kobayashi T, Yoshioka T, Mori H, Iida M, Yoshimura A. The dual function of hepatic SOCS3 in insulin resistance in vivo. Genes Cells. 12(2):143-54. 2007. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation, DNA Sequencing, Microarray) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）
2. Mori H, Shichita T, Yu Q, Yoshida R, Hashimoto M, Okamoto F, Torisu T, Nakaya M, Kobayashi T, Takaesu G, Yoshimura A. Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes. Biochem Biophys Res Commun. 359(4):952-8. 2007. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation, Electron Microscopes) / Division of Molecular and Cellular Immunology）
3. Nishinakamura H, Minoda Y, Saeki K, Koga K, Takaesu G, Onodera M, Yoshimura A, Kobayashi T. An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity. Int Immunol. 19(5):609-19. 2007. [PubMed]
   （Laboratory for Research Support (Mass Spectrum Measurement, DNA Sequencing) / Division of Molecular and Cellular Immunology）
4. Honbou K, Minakami R, Yuzawa S, Takeya R, Suzuki NN, Kamakura S, Sumimoto H, Inagaki F. Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding. EMBO J. 26(4):1176-86. 2007. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Hokkaido University, Division of Cell Biology）
5. Matsumura Y, Kobayashi T, Ichiyama K, Yoshida R, Hashimoto M, Takimoto T, Tanaka K, Chinen T, Shichita T, Wyss-Coray T, Sato K, Yoshimura A. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. J Immunol. 179(4):2170-9. 2007. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Division of Molecular and Cellular Immunology）
6. Onoyama I, Tsunematsu R, Matsumoto A, Kimura T, de Alborán IM, Nakayama K, Nakayama KI. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J Exp Med. (12):2875-88. 2007. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
7. Igura M., Maita N., Obita T., Kamishikiryo J., Maenaka K., Kohda D.(2007) Purification, crystallization and preliminary X-ray diffraction studies of the soluble domain of the oligosaccharyltransferase STT3 subunit from the thermophilic archaeon Pyrococcus furiosus.Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.F63: 798-801. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement, DNA Sequencing) / Division of Structural Biology）
8. Taniguchi K., Kohno RI., Ayada T., Kato R., Ichiyama K., Morisada T., Oike Y., Yonemitsu Y., Maehara Y., Yoshimura A.(2007) Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor-3 signaling.Mol Cell Biol.27(12):4541-50. [PubMed]
   （Laboratory for Research Support (Pathological Specimen Creation, DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）
9. Taniguchi K., Ayada T., Ichiyama K., Kohno R., Yonemitsu Y., Minami Y., Kikuchi A., Maehara Y., Yoshimura A.(2007) Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling. Biochem Biophys Res Commun.26;352(4):896-902. [PubMed]
   （Laboratory for Research Support (Pathological Specimen Creation, DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）

2006（15)

1. Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell. 1(1):101-12. 2006. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Keio University）
2. Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A. IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. J Exp Med. 203(6):1391-7. 2006. [PubMed]
   （Laboratory for Research Support (DNA Sequencing, Mass Spectrum Measurement, Pathological specimen preparation) / Division of Molecular and Cellular Immunology）
3. Chinen T, Kobayashi T, Ogata H, Takaesu G, Takaki H, Hashimoto M, Yagita H, Nawata H, Yoshimura A. Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved. Gastroenterology. 130(2):373-88. 2006. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation, DNA Sequencing, Electron Microscopes, Mass Spectrum Measurement) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）
4. Kinjyo I, Inoue H, Hamano S, Fukuyama S, Yoshimura T, Koga K, Takaki H, Himeno K, Takaesu G, Kobayashi T, Yoshimura A. Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med. 203(4):1021-31. 2006. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation, DNA Sequencing, Electron Microscopes, Mass Spectrum Measurement) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）
5. Ogata H, Kobayashi T, Chinen T, Takaki H, Sanada T, Minoda Y, Koga K, Takaesu G, Maehara Y, Iida M, Yoshimura A. Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis. Gastroenterology. 131(1):179-93. 2006. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation, DNA Sequencing, Electron Microscopes, Mass Spectrum Measurement) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）
6. Aoi N, Masuda T, Murakami D, Yajima T, Mizubuchi H, Yamada H, Kawauchi H, Yoshikai Y. IL-15 prevents allergic rhinitis through reactivation of antigen-specific CD8+ cells. J Allergy Clin Immunol. 2006 Jun;117(6):1359-66. [PubMed]
   （Laboratory for Research Support (Pathological specimen preparation) / Division of Host Defense）
7. Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I. Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system. J Biol Chem. 281(7):4495-506. 2006. [PubMed]
   （Laboratory for Research Support (Mass Spectrum Measurement) / Division of Molecular and Cellular Immunology, Fukushima Medical University）
8. Minoda Y, Saeki K, Aki D, Takaki H, Sanada T, Koga K, Kobayashi T, Takaesu G, Yoshimura A. A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling. Biochem Biophys Res Commun. 2006 Jun 9;344(3):1023-30. [PubMed]
   （Laboratory for Research Support (Mass Spectrum Measurement) / Division of Molecular and Cellular Immunology）
9. Takaki H, Minoda Y, Koga K, Takaesu G, Yoshimura A, Kobayashi T. TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation. Genes Cells. 11(8):871-82. 2006. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Molecular and Cellular Immunology）
10. Lu Y, Fukuyama S, Yoshida R, Kobayashi T, Saeki K, Shiraishi H, Yoshimura A, Takaesu G. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic. J Biol Chem. 2006 Dec 1;281(48):36683-90. 2006. [PubMed]
    （Laboratory for Research Support (DNA Sequencing) / Division of Molecular and Cellular Immunology）
11. Hara K, Nakayama KI, Nakayama K. Geminin is essential for the development of preimplantation mouse embryos. Genes Cells. Nov;11(11):1281-93. 2006. [PubMed]
    （Laboratory of Embryonic and Genetic Engineering / Tohoku University）
12. Tsunematsu R, Nishiyama M, Kotoshiba S, Saiga T, Kamura T, Nakayama KI. Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Mol Cell Biol. 26(16):6157-69. 2006. [PubMed]
    （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
13. Shiraishi H, Okamoto H, Yoshimura A, Yoshida H. ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1. J Cell Sci. 119(Pt 19):3958-66. 2006. [PubMed]
    （Laboratory for Research Support (Electron Microscopes, DNA Sequencing, Pathological specimen preparation) / Division of Molecular and Cellular Immunology, Saga University）
14. Fotovati A, Nakayama K, Nakayama KI. Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice. Cell Div. 2006 Apr 7;1:4. [PubMed]
    （Laboratory for Research Support (Electron Microscopes) / Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
15. Shirane M., Nakayama KI.(2006) Protrudin induces neurite formation by directional membrane trafficking.Science, 314: 818-21. [PubMed]
    （Laboratory for Research Support (Electron Microscopes) / Division of Cell Biology）

2005（7)

1. Taketomi T, Yoshiga D, Taniguchi K, Kobayashi T, Nonami A, Kato R, Sasaki M, Sasaki A, Ishibashi H, Moriyama M, Nakamura K, Nishimura J, Yoshimura A. Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia. Nat Neurosci. 8(7):855-7. 2005. [PubMed]
   （Laboratory for Research Support (DNA Sequencing, Mass Spectrum Measurement, Pathological specimen preparation) / Division of Molecular and Cellular Immunology）
2. Nonami A, Taketomi T, Kimura A, Saeki K, Takaki H, Sanada T, Taniguchi K, Harada M, Kato R, Yoshimura A. The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1. Genes Cells. 10(9):887-95. 2005. [PubMed]
   （Laboratory for Research Support (DNA Sequencing, Electron Microscopes, Pathological specimen preparation) / Division of Molecular and Cellular Immunology）
3. Torisu K, Tsuchimoto D, Ohnishi Y, Nakabeppu Y. Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein. J Biochem. 138(6):763-72. 2005. [PubMed]
   （Laboratory for Research Support (DNA Sequencing) / Laboratory of Embryonic and Genetic Engineering / Division of Neurofunctional Genomics）
4. Suehiro,Y., Muta,K., Nakashima,M. et al(2005) A novel mechanism in suppression of erythropoiesis during inflammation: a crucial role of RCAS1. Eur. J. Haematology, 74:365-373. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Department of Clinical Imunology, Faculty of Medical Sciences, Kyushu University）
5. 神田大輔(2005)蛋白質核酸酵素vol.50.No10 1303-1310. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Structural Biology）
6. Kaneko-Oshikawa,C., Nakagawa,T., Yamada,M., Yoshikawa,H., Matsumoto,M., Yada,M., Hatakeyama,S., Nakayama,K., and Nakayama,KI.(2005) Mammalian E4 Is Required for Cardiac Development and Maintenance of the Nervous System. Mol. Cell Biol., 25: 10953-10964. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
7. Matsumoto M., Hatakeyama S., Oyamada K., Oda Y., Nishimura T., Nakayama KI.(2005) Large-scale analysis of the human ubiquitin-related proteome.Proteomics, 5: 4145-51. [PubMed]
   （Laboratory for Research Support (Proteomics Analysis, Mass Spectrum Measurement) / Division of Cell Biology）

2004（8)

1. Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 18(24):3055-65. 2004. [PubMed]
   （Laboratory for Research Support (Mass Spectrum Measurement, Proteomics Analysis) / Division of Cell Biology）
2. Nishiyama M, Nakayama K, Tsunematsu R, Tsukiyama T, Kikuchi A, Nakayama KI. Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol Cell Biol. 24(19):8386-94. 2004. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
3. Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI. Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem. 279(10):9417-23. 2004. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
4. Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S, Kitagawa M, Iemura S, Natsume T, Nakayama KI. Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell. 6(5):661-72. 2004. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
5. Ide Y, Tsuchimoto D, Tominaga Y, Nakashima M, Watanabe T, Sakumi K, Ohno M, Nakabeppu Y. Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood. 104(13):4097-103. 2004. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Neurofunctional Genomics）
6. Ichinoe,A., Behmanesh,M., Tominaga,Y., Ushijima,Y., Hirano,S., Sakai,Y., Tsuchimoto,D., Sakumi,K., Wake,N., and Nakabeppu,Y.(2004)Identification and characterization of two forms of mouse MUTYH proteins encoded by alternatively spliced transcripts. Nucleic Acids Res., 32:477-87. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Neurofunctional Genomics）
7. Nakabeppu,Y., Tsuchimoto,D., Ichinoe,A., Ohno,M., Ide,Y., Hirano,S., Yoshimura,D., Tominaga,Y., Furuichi,M. and Sakumi,K. (2004) Biological Significance of the Defense Mechanisms against Oxidative Damage in Nucleic Acids Caused by Reactive Oxygen Species: from Mitochondria to Nuclei. Ann N. Y. Acad. Sci., 1011, 101-112. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Neurofunctional Genomics）
8. Shirasawa,S., Sugiyama,S., Baba,I., Inokuchi,J., Sekine,S., Ogino,K., Kawamura,Y., Dohi,T., Fujimoto,M., and Sasazuki,T.(2004) Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc. Natl. Acad. Sci. U.S.A., 101:13921-6. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Immunogenetics / Department of Pathology, International Medical Center Japan Research Institute）

2003（5)

1. Xu P, Yoshioka K, Yoshimura D, Tominaga Y, Nishioka T, Ito M, Nakabeppu Y. In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis. J Biol Chem. 278(48):48422-33. 2003. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Neurofunctional Genomics）
2. Nakayama K, Hatakeyama S, Maruyama S, Kikuchi A, Onoé K, Good RA, Nakayama KI. Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene. Proc Natl Acad Sci U S A. 100(15):8752-7. 2003. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
3. Tahara,K., Tsuchimoto,D., Tominaga,Y., Asoh,S., Ohta,S., Kitagawa,M., Horie,H., Kadoya,T. and Nakabeppu,Y. (2003) DeltaFosB but not FosB Induces Delayed Apoptosis Independent of Cell Proliferation in the Rat1a Embryo Cell Line. Cell Death Diff., 10:496-507. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Neurofunctional Genomics）
4. Yoshimura,D., Sakumi,K., Ohno,M., Sakai,Y., Furuichi,M., Iwai,S. and Nakabeppu,Y. (2003) An oxidized purine nucleoside triphosphatase, MTH1 suppresses cell death caused by oxidative stress. J. Biol. Chem., 278:37965-37973. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Neurofunctional Genomics）
5. Saeki,K., Miura,Y., Aki,D., Kurosaki,T., and Yoshimura,A.(2003) The B cell-specific major raft protein, Raftlin is necessary for the integrity of lipid raft and BCR signal transduction. EMBO J., 22:3015-3026. [PubMed]
   （Laboratory for Research Support (Mass Spectrum Measurement) / Division of Molecular and Cellular Immunology）

2002（8)

1. Kanematsu T, Jang IS, Yamaguchi T, Nagahama H, Yoshimura K, Hidaka K, Matsuda M, Takeuchi H, Misumi Y, Nakayama K, Yamamoto T, Akaike N, Hirata M, Nakayama K. Role of the PLC-related, catalytically inactive protein p130 in GABA(A) receptor function. EMBO J. 21(5):1004-11. 2002. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Faculty of Dental Science, Kyushu University / Division of Cell Biology）
2. Ide Y, Tsuchimoto D, Tominaga Y, Iwamoto Y, Nakabeppu Y. Characterization of the genomic structure and expression of the mouse Apex2 gene. Genomics. 81(1):47-57. 2002. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Neurofunctional Genomics）
3. Sasaki,M., Miyazaki,K., Koga,Y., Kimura,G., Nomoto,K., and Yoshida,H.(2002)Calcineurin-dependent mitochondrial disturbances in calcium-induced apoptosis of human immunodeficiency virus gp160-expressing CD4+ cells. J. Virol., 76(1):416-20. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Molecular and Cellular Immunology）
4. Hara,H., Takeda,A., Takeuchi,M., Wakeham,AC., Itie,A., Sasaki,M., Mak,TW., Yoshimura,A., Nomoto,K., and Yoshida,H.(2002)The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes. J.Immunology, 168:2288-2295. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Molecular and Cellular Immunology）
5. Yoshida,H., Okada,Y., Kinoshita,N., Hara,H., Sasaki,M., Sawa,H., Nagashima,K., Mak,TW., Ikeda,K., and Motoyama,N.(2002)Differential requirement for Apaf1 and Bcl-X(L) in the regulation of programmed cell death during development. Cell Death Differ., 9:1273-6. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Molecular and Cellular Immunology）
6. Nakamichi,I., Hatakeyama,S., and Nakayama,KI.(2002)Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18. Mol. Biol. Cell, 13:3441-3451. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Cell Biology）
7. Minamishima,YA., Nakayama,K., and Nakayama,K.(2002) Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice. Cancer Res., 62:995-9. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
8. Miyamoto,A., Nakayama,K., Imaki,H., Hirose,S., Jiang,Y., Abe,M., Tsukiyama,T., Nagahama,H., Ohno,S., Hatakeyama,S., and Nakayama,KI.(2002) Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature, 416:865-9. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）

2001（7)

1. Nakabeppu,Y. (2001) Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage. Progress of Nucleic Acid Research and Molecular Biology, 68:75-94. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Neurofunctional Genomics）
2. Nakabeppu,Y., Tominaga,Y., Tsuchimoto,D., Ide,Y., Hirano,S., Sakai,Y., Sakumi,K. and Furuichi,M. (2001) Mechanisms Protecting Genomic Integrity from Damage Caused by Reactive Oxygen Species: Implications for Carcinogenesis and Neurodegeneration. Environmental Mutagen Research, 23:197-209. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Neurofunctional Genomics）
3. Miyazaki,K., Yoshida,H., Sasaki,M., et al (2001) Caspase-independent cell death and mitochondrial disruption observed in the Apaf1-deficient cells. J.Biochem.(Tokyo)129:963-969[PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Molecular and Cellular Immunology）
4. Tsuchimoto,D., Sakai,Y., Sakumi,K., Nishioka,K., Sasaki,M., Fujiwara,T. and Nakabeppu,Y. (2001) Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen. Nucleic Acids Res., 29:2349-2360. [PubMed]
   （Laboratory for Research Support (Electron Microscopes) / Division of Neurofunctional Genomics）
5. Tsukiyama,T., Ishida,N., Shirane,M., Minamishima,YA., Hatakeyama,S., Kitagawa,M., Nakayama,K., and Nakayama,K.(2001) Down-regulation of p27Kip1 expression is required for development and function of T cells. J. Immunol., 166:304-12. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
6. Nagahama,H., Hatakeyama,S., Nakayama,K., Nagata,M., Tomita,K., and Nakayama,K.(2001) Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development. Anat. Embryol., 203:77-87. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
7. Fukui,Y., Hashimoto,O., Sanui,T., Oono,T., Koga,H., Abe,M., Inayoshi,A., Noda,M., Oike,M., Shirai,T., and Sasazuki,T.(2001) Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature, 412:826-31. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Immunogenetics）

2000（3)

1. Shimoda,K., Kato,K., Aoki,K., Matsuda,T., Miyamoto,A., Shibamori,M., Yamashita,M.,.Numata,A., Takase,K., Kobayashi,S., Shibata,S., Asano,Y., Gondo,H., Sekiguchi,K., Nakayama,K., Nakayama,T., Okamura,T., Okamura,S., Niho,Y., and Nakayama,K.(2000) Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity,13:561-71. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）
2. Nakayama,K., Nagahama,H., Minamishima,YA., Matsumoto,M., Nakamichi,I., Kitagawa,K., Shirane,M., Tsunematsu,R., Tsukiyama,T., Ishida,N., Kitagawa,M., Nakayama,K., and Hatakeyama,S.(2000) Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J.,19:2069-81. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Embryonic and Genetic Engineering）
3. Kitagawa,K., Kawamoto,T., Kunugita,N., Tsukiyama,T., Okamoto,K., Yoshida,A., Nakayama,K., and Nakayama,K.(2000) Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. FEBS Lett., 476:306-11. [PubMed]
   （Laboratory of Embryonic and Genetic Engineering / Division of Cell Biology）