九州大学 生体防御医学研究所

下記のとおり、アメリカ Washington University in St. Louis School of Medicine のQingyun Li博士によるセミナーを開催いたします。
Li博士は、神経免疫学を専門とする研究者で、脳内の免疫細胞であるミクログリアに着目し、シングルセルゲノミクスや分子・細胞生物学的手法を用いて、ミクログリアの発生や多様性、神経回路形成への役割、さらにAlzheimer's diseaseや自閉スペクトラム症などの神経疾患との関連について、世界をリードする研究を行っています。
本セミナーでも最新の興味深い話が聴けると思います。皆様のご来聴を歓迎いたします。

(Seminar in English)

演題 / Title

Tracking reactive microglial state across the lifespan

演者 / Speaker

Qingyun Li, PhD
Assistant Professor
Department of Neuroscience, Washington University in St. Louis School of Medicine

日時 / Date

２０２６年８月３日（月） /　Aug 3 (Mon), 2026
16：00〜17：00

会場 / Venue

病院キャンパス 総合研究棟 1階 講義室102
（「キャンパスマップ」の35番の建物）

Lecture Room 102, 1F, Biomedical Research Station, Hospital Campus
(Building No. 35 on the [Campus Map])

要 旨 / Abstract

Single-cell RNA sequencing studies have revealed transcriptionally distinct microglial states across development, aging, and disease. These include proliferative region–associated microglia (PAMs) in the developing white matter, disease-associated microglia (DAMs) common to many neurodegenerative conditions, and white matter–associated microglia (WAMs) in the aged brain, among others. Interestingly, PAMs, DAMs, and WAMs share a core gene signature and overlapping functional properties. However, it remains unclear whether these subsets represent ontogenically distinct lineages or instead reflect plastic transitions of microglial states driven by converging signals. The temporal dynamics, regulatory mechanisms, and functional implications of microglial state changes also remain poorly understood. Using a specific inducible driver line, Clec7a-CreERT2, recently developed by us, we track PAMs and DAMs across conditions and lifespan, revealing the extraordinary plasticity of reactive microglial states. We further employ highly sensitive epigenomic profiling to identify the cis- and trans-regulatory elements that govern these transitions. These studies uncover the intricate relationships and dynamic nature of spatially and temporally discrete microglial states in health and disease.

参考論文 / References

1. Li Q*, Cheng Z, Zhou L, Darmanis S, Neff NF, Okamoto J, Gulati G, Bennett ML, Sun LO, Clarke LE, Marschallinger J, Yu G, Quake SR, Wyss-Coray T, Barres BA. Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing. Neuron. 2019 Jan 16;101(2):207-223.e10.
2. Barclay KM, Abduljawad N, Cheng Z, Kim MW, Zhou L, Yang J, Rustenhoven J, Mazzitelli Perez J, Smyth LCD, Kapadia D, Brioschi S, Beatty W, Hou JC, Saligrama N, Colonna M, Yu G, Kipnis J, Li Q*. An inducible genetic tool for tracking and manipulating specific microglial states in development and disease. Immunity. 2024 Jun 11;57(6):1394-1412.e8.
3. Hamagami N, Kapadia D, Barclay KM, Huang Y, Abduljawad N, Cheng Z, McLaughlin L, Singhania D, Ding X, Yang J, Sun Z, Karra V, Du S, Bayguinov P, Yu G, Li YE, Gabel HW*, Li Q*. State-specific enhancer landscapes govern microglial plasticity. Immunity. 2026 Feb 10;59(2):288-305.e11.
4. Naz H, Palovics R, Yamada S, Lu N, Wyss-Coray T, Li Q*, Zhao G*. Core activation program and selective responsiveness of microglia in aging and parabiosis. bioRxiv. 2025. In revision. doi: https://doi.org/10.1101/2025.10.29.685417.

連絡先 / Contact

増田 隆博
生体防御医学研究所　分子神経免疫学分野
092 (642) 6800
takahiro.masuda[＠]bioreg.kyushu-u.ac.jp
(※[]を外し半角@に変更ください。)

Takahiro Masuda
Division of Molecular Neuroimmunology, Medical Institute of Bioregulation
TEL: 092 (642) 6800
E-mail: takahiro.masuda[＠]bioreg.kyushu-u.ac.jp
(Please remove the square brackets and replace them with the '@' symbol.)