九州大学 生体防御医学研究所

下記の通り、オーストリア Max Perutz研究所にてPIをされている大塚正太郎先生によるセミナーを開催いたします。皆様のご来聴を心より歓迎いたします。

※スライドは全て英語ですが、発表は日本語で行われます。質問は英語でも日本語でも構いません。

演題 / Title

小胞体、核膜、核膜孔のダイナミクスの高時空間分解能解析

Revealing the dynamics of endoplasmic reticulum, nuclear envelope, and nuclear pores at high spatio-temporal resolution

演者 / Speaker

大塚 正太郎 博士

Group Leader
Max Perutz Labs, Vienna Biocenter, Austria

日時 / Date

２０２５年６月１０日（火） /　June 10 (Tue), 2025
16：00〜17：00

場所 / Venue

病院キャンパス 総合研究棟 1階 講義室 102
以下の地図の34番です。
キャンパスマップ

Lecture Room 102, 1F, Biomedical Research Station, Hospital Campus
No.34 on the following linked map.
Campus Map

要 旨 / Abstract

The nuclear envelope (NE) regulates nuclear functions, including transcription, nucleocytoplasmic transport, and protein quality control. While the outer membrane of the NE is directly continuous with the endoplasmic reticulum (ER), the NE has an overall distinct protein composition from the ER. During open mitosis in higher eukaryotes, the NE disassembles at mitotic entry and then reforms as a functional territory at the end of mitosis to reestablish nuclear-cytoplasmic compartmentalization. How the NE reassembles from the ER in late mitosis, and how NE identity is maintained within the continuous ER–NE endomembrane system in interphase, has been unclear. By combining live imaging with three-dimensional electron microscopy, we have visualized the dynamic change of the ER and NE during open mitosis at high spatiotemporal resolution in mammalian cells. The results that we obtained will be discussed in the seminar.

業績 / Publications

• Otsuka et al. A quantitative map of nuclear pore assembly reveals two distinct mechanisms, Nature 613(7944):575-581 (2023). DOI: 10.1038/s41586-022-05528-w.
• Bragulat-Teixidor et al. The endoplasmic reticulum connects to the nucleus by constricted junctions that mature after mitosis, EMBO Rep. 25(7):3137-3159 (2024). DOI: 10.1038/s44319-024-00175-w.

連絡先 / Contact

生体防御医学研究所　トランススケール構造生命科学分野
稲葉 謙次
092 (642) 6968
kenji.inaba[＠]bioreg.kyushu-u.ac.jp
(※[]を外し半角@に変更ください。)

Division of Trans-Scale Structural Life Science, Medical Institute of Bioregulation
Kenji Inaba
TEL: 092 (642) 6968
E-mail: kenji.inaba[＠]bioreg.kyushu-u.ac.jp
(Please remove the square brackets and replace them with the '@' symbol.)