九州大学 生体防御医学研究所

下記の通り、Marco Prinz 先生によるセミナーを開催いたします。皆様のご来聴を心より歓迎いたします。

(Seminar in English)

演題 / Title

The myeloid side of the brain

演者 / Speaker

Marco Prinz 教授 （M.D., Ph.D.）
Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Germany

日時 / Date

２０２５年５月９日（金） /　May 9 (Fri), 2025
16：00〜17：00

場所 / Venue

病院キャンパス 総合研究棟 1階 講義室 102
以下の地図の34番です。
キャンパスマップ

Lecture Room 102, 1F, Biomedical Research Station, Hospital Campus
No.34 on the following linked map.
Campus Map

要 旨 / Abstract

As tissue resident macrophages of the central nervous system (CNS) parenchyma, microglia perform diverse essential functions during homeostasis and perturbations. They primarily interact with neurons via synaptic engulfment and through the rapid elimination of apoptotic cells and nonfunctional synapses. Here, by combining unbiased lipidomics and high resolution spatial lipid imaging, deep single-cell transcriptome analysis and novel cell type-specific mutants, we identified a previously unknown mode of microglial interaction with neurons. During homeostasis, microglia deliver the lysosomal enzyme b-hexosaminidase to neurons for the degradation of the ganglioside GM2 that is integral to maintaining cell membrane organization and function. Absence of Hexb, encoding the β subunit of b-hexosaminidase, in both mice and patients suffering from neurodegenerative Sandhoff disease leads to a massive accumulation of GM2 derivatives in a characteristic spatiotemporal manner. In mice, neuronal GM2 gangliosides subsequently engage the macrophage galactose-type lectin (MGL)2 receptor on microglia via N-acetylgalactosamine (GalNAc) residues, leading to lethal neurodegeneration. Notably, microglial replacement is able to break this degenerative cycle and fully restore CNS homeostasis.

業績 / Publications

• Amann L et al. Extrasinusoidal macrophages are a distinct subset of immunologically active dural macrophages, Science Immunology 9(102), 2024.
• Vinnakota JM et al. Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome, Nature Cancer 5(8), 2024.
• Sankowski R et al. Multiomic spatial landscape of innate immune cells at human central nervous system borders, Nature Medicine 30(1), 2024.
• Amann L et al. Mechanisms of myeloid cell entry to the healthy and diseased central nervous system, Nature Immunology 24(3), 2023.
• Masuda T et al. Specification of CNS macrophage subsets occurs postnatally in defined niches, Nature 604(7907), 2022.

連絡先 / Contact

生体防御医学研究所　分子神経免疫学分野
増田　隆博
092 (642) 6800
takahiro.masuda[＠]bioreg.kyushu-u.ac.jp
(※[]を外し半角@に変更ください。)

Division of Molecular Neuroimmunology, Medical Institute of Bioregulation
Takahiro Masuda
TEL: 092 (642) 6800
E-mail: takahiro.masuda[＠]bioreg.kyushu-u.ac.jp
(Please remove the square brackets and replace them with the '@' symbol.)