九州大学 生体防御医学研究所

下記の通り、Dr. Min Woo Kim によるセミナーを開催いたします。皆様のご来聴を心より歓迎いたします。

(Seminar in English)

演題 / Title

Guardian Autoimmunity: How Endogenous Regulatory Peptides Modulate Brain Autoimmunity

演者 / Speaker

Min Woo Kim 氏（Ph.D.）
Washington University in St. Louis, USA

日時 / Date

２０２４年１２月２日（月） /　Dec. 2 (Mon), 2024
16：00〜17：00

場所 / Venue

病院キャンパス 総合研究棟 1階 講義室 102
以下の地図の34番です。
キャンパスマップ

Lecture Room 102, 1F, Biomedical Research Station, Hospital Campus
No.34 on the following linked map.
Campus Map

要 旨 / Abstract

The rediscovery of a bona fide network of lymphatics in the meninges, membranous coverings enveloping the central nervous system (CNS), galvanized a need to reevaluate CNS immune privilege. Indeed, with intimate interactions occurring between brain-resident and adaptive immune cells at the borders of the brain, this physical reconnection between the CNS and the peripheral immune system brings attention to an intriguing question. How does the CNS retain responsivity to immunological inputs while maintaining immune privilege? In searching for molecular cues deriving from the CNS that would allow direct communication with the adaptive immune system, we discovered a repertoire of CNS-derived endogenous peptides presented on major histocompatibility complex II (MHC II) molecules. A preponderance of these endogenous MHC II-bound peptides were found to be bound throughout the path of lymphatic drainage beginning from the brain to its surrounding meninges and its draining cervical lymph nodes. During neuroinflammatory disease, however, the presentation of these endogenous peptides drastically diminished. By then resupplying the CNS with these endogenous peptides, a population of suppressor CD4⁺ T cells expanded locally that sufficiently suppressed against CNS autoimmunity. Moreover, isolation of these CD4⁺ T cells further clarified and provided novel mechanistic insight to their suppressive function, adding another layer of protection at the brain borders. Collectively, these findings elucidate a pivotal function for endogenous self-peptides in CNS immunosurveillance and in the maintenance of CNS immune privilege.

参考論文 / References

• Min Woo Kim et al. Endogenous self-peptides guard immune privilege of the central nervous system. Nature, 2024.

連絡先 / Contact

生体防御医学研究所　アレルギー防御学分野
伊藤　美菜子
092 (642) 6965

Division of Allergy and Immunology, Medical Institute of Bioregulation
Minako Ito
TEL: 092 (642) 6965