第837回 生医研セミナー(多階層生体防御システム研究拠点)
下記の通り、行川先生によるセミナーを開催します。発表言語は英語ですが、Q&Aなどは日本語可です。
皆様のご来聴を心より歓迎致します。
※セミナーは英語で行われます。(Seminar in English)
演題 / Title
Stem cell potency and cellular identity in the germline
演者 / Speaker
行川 賢 先生
Satoshi Namekawa, Ph.D.
Professor
Department of Microbiology & Molecular Genetics, University of California, Davis
日時 / Date
２０２３年７月４日（火） / Jul. 4 (Tue), 2023
17：30〜
場所 / Venue
病院キャンパス 総合研究棟 1階 セミナー室105
地図の34番です。
Seminar Room 105, 1F, Biomedical Research Station, Hospital Campus
No.34 on the map.
要 旨 / Abstract
Spermatogonial stem cells (SSCs) support life-long fertility in adult males by balancing self-renewal anddifferentiation to produce haploid gametes in a slow-cycling cell population. We discover that an epigenetic regulator, Polycomb repressive complex 1 (PRC1), shields SSC potency, maintains slow cycling, and directs commitment o differentiation during steady-state spermatogenesis in adults. Importantly, unlike other tissue-specific stem cells where PRC1 promotes cell cycle progression, PRC1 functions as a negative regulator of the SSC cell cycle that maintains slow cycling. Further, by performing a high-resolution Hi-C analysis of representative stages of mouse spermatogenesis, we found that 3D chromatin predetermines gene expression programs required for spermatogenesis. We propose that CTCF-mediated 3D chromatin underlines epigenetic priming to direct unidirectional differentiation in the male germline.
参考論文 / References
- Alavattam KG, et al. Nat Struct Mol Biol. 2019;26(3):175-84.
- Maezawa S, et al.
Nat Struct Mol Biol, 2020; 27(10): 978-988. - Sakashita A, et al.
Nat Struct Mol Biol, 2020; 27 (10): 967-977. - Hu M, et al.
Nat Commun, 2022;13(1):4510. - Abe H, et al.
Nat Commun, 2022;13(1):7212.
連絡先 / Contact
生体防御医学研究所 佐々木研究室（エピゲノム制御学）
特任講師 久保 直樹
092（642）6760
Sasaki Laboratory (Epigenomics and Development), Medical Institute of Bioregulation
Naoki Kubo, M.D., Ph.D. （Research Lecturer）
TEL: 092 (642) 6760