- 2026年9月9日
- 2026年9月9日
Our collaborative study with the Maeshima lab at the National Institute of Genetics has been published in Nature Genetics!
Our collaborative study with Professor Kazuhiro Maeshima’s laboratory at the National Institute of Genetics was published in Nature Genetics on September 8, 2026. Using imaging approaches in living human cells, the study revealed that transcriptionally active euchromatin forms condensed domains. It further showed that cohesin constrains chromatin motion within these domains and prevents neighboring domains from mixing. From our laboratory, Assistant Professor Yoshiaki Kobayashi and Professor Hiroshi Ochiai contributed to visualizing nascent RNA and analyzing simultaneous transcription of spatially proximal genes using intron-seqFISH. This analysis showed that cohesin depletion increased the frequency of simultaneous transcription between nearby genes. These findings suggest that the structure and dynamics of chromatin domains help maintain transcriptional independence between genes. Read the paper／Press release from the National Institute of Genetics／Press release from Kyushu University (in Japanese) Image credit: Shiori Iida, Sachiko Tamura, Kazuhiro Maeshima, National Institute of Genetics, ROIS. Source: EurekAlert!