In our laboratory, we employ advanced techniques—including live imaging, multimodal spatial omics, genome editing, molecular cell biology, and biophysics—using mouse early embryos, adult, and embryonic stem (ES) cells as models, to achieve the following objectives:
- Elucidation of the regulatory mechanisms of transcriptional bursting
- Elucidation of the impact of transcriptional bursting-associated gene expression heterogeneity on cell fate decisions
- Elucidation of the mechanisms underlying the age-related increase in intercellular gene expression heterogeneity
