九州大学 生体防御医学研究所

下記の通り、栄川 健 先生によるセミナーを開催します。皆様のご来聴を心より歓迎致します。


※セミナーは日本語で行われます。

演題 / Title

Lymphocyte proliferation and stemness, a lesson from tumor suppression

演者 / Speaker

栄川 健 先生 / Takeshi Egawa, M.D., Ph.D.
Associate Professor
Department of Pathology and Immunology,
Washington University School of Medicine

日時 / Date

２０２４年１月２２日（月） /　Jan. 22 (Mon), 2024
17：00〜18：00

場所 / Venue

病院キャンパス 総合研究棟 1階 セミナー室105
以下の地図の34番です。
キャンパスマップ

Seminar Room 105, 1F, Biomedical Research Station, Hospital Campus
No.34 on the following linked map.
Campus Map

要 旨 / Abstract

Lymphocytes are capable of robust expansion upon antigen receptor stimulation and are one of the most rapidly dividing cells in postnatal organisms. Such robust proliferative capacity is critical for establishing broad antigen receptor repertoires during development and for quantitatively amplifying antigen-specific immunity upon pathogen invasion. However, like many other primary cells, they have limited proliferative capacity as expanding lymphocytes undergo terminal differentiation with transient functionality at the expense of their longevity. Such transition of an undifferentiated progenitor cell to more mature states with professional function following a proliferative burst is seen at several checkpoints during the development of lymphocytes as well as other cell types. We predict that it is a process controlled by gene regulatory circuitry closely associated with rapid cell proliferation although the molecular basis remains undefined. Furthermore, the maintenance of population dynamics rather than the size of each population, by generating newly differentiated cells may be fundamental for sustaining functionality of a specific cell population. We have been studying the biological significance of the restriction of cell stemness tightly coupled with cell proliferation, potential manipulation to overcome the restriction, and consequences of perturbed population turnover in lymphocytes. I will discuss these questions in the context of gene regulatory networks initiated by the transcription factor c-MYC, tumor suppression and T cell exhaustion.

参考論文 / References

1. Xia Y. et al.
   BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen. Immunity 55:1200-1215, 2022.
2. Daniel B. et al.
   Divergent clonal differentiation trajectories of T cell exhaustion. Nat Immunol. 23(11):1614-1627, 2022.
3. Ganaie SS. et al.
   Lrp1 is a host entry factor for Rift Valley fever virus. Cell 184(20):5163-5178, 2021.

連絡先 / Contact

生体防御医学研究所　システム免疫学統合研究センター　粘膜防御学分野
澤 新一郎
092 (642) 6973

Division of Mucosal Immunology,
Research Center for Systems Immunology, Medical Institute of Bioregulation
Shinichiro Sawa
TEL: 092 (642) 6973