第835回 生医研セミナー(多階層生体防御システム研究拠点)
下記の通り、Masatoshi Suzuki 先生によるセミナーを開催します。皆様のご来聴を心より歓迎致します。
演題 / Title
ヒトiPS細胞を用いた神経筋疾患および筋骨格系疾患の培養モデルの作成とその応用
演者 / Speaker
Masatoshi Suzuki, Ph.D., D.V.M.
Professor
Department of Comparative Biosciences and Stem Cell & Regenerative Medicine Center, University of Wisconsin-Madison, Wisconsin, USA.
日時 / Date
２０２３年３月３０日（木） / Mar. 30 (Thu), 2023
17：00〜18：00
場所 / Venue
病院キャンパス 総合研究棟 1階 講義室101
以下の地図の34番です。
https://www.kyushu-u.ac.jp/f/47904/HOSPTAL_Jp.pdf
Lecture Room 101, 1F, Biomedical Research Station, Hospital Campus
No.34 on the following linked map.
https://www.kyushu-u.ac.jp/f/47905/HOSPTAL_Eng.pdf
要 旨 / Abstract
Neuromuscular diseases are caused by functional defects of skeletal muscles directly via muscle pathology or indirectly via the nervous system. Extensive studies have been performed to improve the outcomes of therapies; however, effective treatment strategies have not been fully established in any major neuromuscular disease. Human induced pluripotent stem cells (iPSCs) have a great capacity to differentiate into skeletal muscle progenitor cells (or know as myogenic progenitors) and skeletal myocytes for use in treating and modeling neuromuscular diseases. Further, recent innovations in bioengineering provide multifactorial and multidimensional controlled platforms for biomedical research beyond the traditional culture systems. Specifically, patient-derived iPSCs can be applied to differentiate into mature skeletal myotubes using newly featured cell culture systems such as two-dimensional (2D) skeletal-muscle-on-a-chip and three-dimensional (3D) skeletal muscle organoids. These bioengineering approaches can more closely mimic the native cellular environment and pathology in culture. Skeletal myotubes derived from patient‐specific iPSC lines are a valuable resource for studying neuromuscular disease mechanisms and testing potential drug therapies.
連絡先 / Contact
生体防御医学研究所 トランスクリプトミクス分野
大川 恭行
092 (642) 4534
Division of Transcriptomics, Medical Institute of Bioregulation
Yasuyuki Ohkawa
TEL: 092 (642) 4534