第689回 生医研セミナー(多階層生体防御システム研究拠点)
下記の通り、アメリカ・Yale大学の渡部聡朗博士によるセミナーを開催致します。
皆様のご来聴を心より歓迎いたします。講演は英語で行われます。
演題
RNA regulatory network mediated by Piwi proteins and piRNAs
（seminar in English）
演者
渡部 聡朗 博士 Dr. Toshiaki Watanabe
Associate Research Scientist, Yale University, USA
日時
2015年 2月16日（月） Feb. 16 (Mon), 2015
14：00～15：00
場所
九州大学 病院キャンパス内 生体防御医学研究所 本館1階 会議室
以下の地図の23番の建物になります。
（http://www.kyushu-u.ac.jp/access/map/hospital/hospital.html）
Seminar Room, 1F, Main Building, Medical Institute of Bioregulation
No.23 on the following linked map.
（http://www.kyushu-u.ac.jp/access/map/hospital/hospital-e.html）
要旨
The genomes of complex eukaryotes contain vast intergenic regions that are mostly composed of repetitive DNA, with transposons as a major constituent. Although it is now apparent that some transposons and pseudogenes participate in gene regulation, the function of the majority of these sequences remains unknown. Piwi proteins regulate retrotransposons for degradation using piRNAs as guides in the germline across the animal kingdom. We recently found that piRNAs mediate the degradation of a large number of mRNAs and lncRNAs in the mouse germline. In this regulation, retrotransposon and pseudogenes function as regulatory sequences, and retrotransposon sequences in the 3´UTRs of mRNAs are targeted by piRNAs for degradation. Many genes harbor retrotransposon sequences in their 3´UTRs and promoters. To find novel retrotransposon regulators potentially involved in the regulation of such genes, I am planning to perform RNAi screening.
業績
- Watanabe, T. et al.
Retrotrasposons and pseudogenes regulate mRNAs and lncRNAs via the piRNA pathway in the germline. Genome Res (in press) 2014 - Watanabe, T. et al.
Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs. Mol. Cell, 56, 18-27, 2014
連絡先
生体防御医学研究所 エピゲノム制御学分野 佐々木 裕之
Division of Epigenomics and Development, MIB, Hiroyuki SASAKI
電話：092-642-6759