The 787th MIB Seminar
(Joint Usage/Research Center for the Multi-stratified Host Defense System)
[Seminar in English]
Title
Targeting Cell Signaling Pathways for Cancer Therapies
Speaker
Professor Wenyi Wei
Beth Israel Deaconess Medical Center, Harvard Medical School
Date
Mar. 5 (Tue), 2019
17：00～19：00
Venue
Seminar Room, 1F, Main Building, Medical Institute of Bioregulation, Hospital Campus
No.31 on the following linked map.
（http://www.kyushu-u.ac.jp/f/33952/2018hospital_2-en.pdf）
Publications
- Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira NT, Tan Y, Ci Y, Wu F, Dai X, Guo J, Huang YH, Fan C, Ren S, Sun Y, Freeman GJ, Sicinski P, Wei W.
Nature. 2018 Jan 4;553(7686):91-95. - TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.
Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, Guo J, Zhang J, North BJ, Dai X, Cheng X, Bian X, Zhang L, Harper JW, Sun SC, Wei W.
Nature. 2017 May 18;545(7654):365-369. - pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.
Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG Jr, Wei W.
Science. 2016 Aug 26;353(6302):929-32. - Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W.
Nature. 2014 Apr 24;508(7497):541-5. - Acetylation-dependent regulation of Skp2 function.
Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W.
Cell. 2012 Jul 6;150(1):179-93. - SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W.
Nature. 2011 Mar 3;471(7336):104-9. - Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.
Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr.
Nature. 2004 Mar 11;428(6979):194-8.
Contact
Division of Cell Biology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation
Keiichi Nakayama
TEL: 092(642)6815