The 778th MIB Seminar (Joint Usage/Research Center for the Multi-stratified Host Defense System)
joint with the seminar of Grant-in-Aid for Scientific Research on Innovative Areas「Ensuring integrity in gametogenesis」
[Seminar in English]
Title
Epigenetics in the male germline from stem cells to sperm
Speaker
Dr. Satoshi Namekawa
Associate Professor
Division of Reproductive Sciences
Cincinnati Children's Hospital Medical Center
Date
Nov. 15 (Thu), 2018
17：00～18：00
Venue
Seminar Room, 1F, Main Building, Medical Institute of Bioregulation, Hospital Campus
No.31 on the following linked map.
（http://www.kyushu-u.ac.jp/f/33952/2018hospital_2-en.pdf）
Abstract
The epigenetic mechanisms of germ cells are ultimately responsible for the perpetuity of life. Male germ cells undergo the major transition: the mitosis-to-meiosis transition in spermatogenesis. Recently, we identified two major epigenetic mechanisms that govern this transition. While superenhancers drive robust expression of spermatogenesis genes, endogenous retroviruses function as enhancers and drive species-specific transcriptomes. Furthermore, by performing Hi-C (genome-wide chromosome conformation capture), we reveal the 3D chromatin organization of male germ cells from the meiotic stage to sperm. These chromatin characteristics undergo progressive strengthening and consolidation to form an abundance of constrained topological associated domains (TADs) in mature sperm.
References
Maezawa S, Hasegawa K, Yukawa M, Kubo N, Sakashita A, Alavattam KG, Sin HS, Kartashov AV, Sasaki H, Barski A, Namekawa SH.
Polycomb protein SCML2 facilitates H3K27me3 to establish bivalent domains in the male germline.
Proc Natl Acad Sci U S A. 2018 May 8; 115(19):4957-4962.
Contact
Division of Epigenomics and Development, MIB
Hiroyuki SASAKI
Phone：092(642)6759