Division of Epigenomics and Development, Department of Molecular and Structural Biology, Medical Institute of Bioregulation, Kyushu University

Publication List

Publication List

Professor(Kindai University) : Takashi Sado

Original Research Papers

Ohishi, H.*, Au Yeung, W.K.*, Unoki, M., Ichiyanagi, K., Fukuda, K., Maenohara, S., Shirane, K., Chiba, H., Sado, T. & Sasaki, H. (*These authors equally contributed to the work.): Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells.; Genes Cells 25, 54-64 (2020); PubMed

Sakakibara, Y., Nagao, K., Blewitt, M., Sasaki, H., Obuse, C. & Sado, T.: Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice.; Development 145, dev166462 (2018); PubMed

Chigi, Y., Sasaki, H. & Sado, T.: The 5' region of Xist RNA has the potential to associate with chromatin through the A-repeat.; RNA 23, 1894-1901 (2017); PubMed

Sakata, Y., Nagao, K., Hoki, Y., Sasaki, H., Obuse, C. & Sado, T.: Defects in dosage compensation impact global gene regulation in the mouse trophoblast.; Development 144, 2784-2797 (2017); PubMed

Amakawa, Y., Sakata, Y., Hoki, Y., Arata, S., Shioda, S., Fukagawa, T., Sasaki, H. & Sado, T.: A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.; Development 142, 4299-4308 (2015); PubMed

Yamamoto, Y., Watanabe, T., Hoki, Y., Shirane, K., Li, Y., Ichiyanagi, K., Kuramochi-Miyagawa, S., Toyoda, A., Fujiyama, A., Oginuma, M., Suzuki, H., Sado, T., Nakano, T. & Sasaki, H.: Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus.; Genome Res. 23, 292-299 (2013); PubMed

Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D. & Sasaki, H.: Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.; Science 332, 848-52 (2011); PubMed

Hoki, Y., Ikeda, R., Mise, N., Sakata, Y., Ohhata, T., Sasaki, H., Abe, K. & Sado, T.: Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse; Development 138, 2649-59 (2011); PubMed

Watanabe, T., Chuma, S. Yamamoto, Y., Kuramochi-Miyagawa, S., Totoki, Y., Toyoda, A., Hoki, Y., Fujiyama, A., Shibata, T., Sado, T., Noce, T., Nakano, T., Nakatsuji, N., Lin, H. & Sasaki, H.: MitoPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.; Dev. Cell 20, 364-375 (2011); PubMed

Inoue, K., Kohda, T., Sugimoto, M., Sado, T., Ogonuki, N., Matoba, S., Shiura, H., Ikeda, R., Mochida, K., Fujii, T., Sawai, K., Otte, A.P., Tian, X.C., Yang, X., Ishino, F., Abe, K. & Ogura, A..: Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer.; Science 330, 496-499 (2010); PubMed

Hoki, Y., Kimura, N., Kanbayashi, M., Ohhata, T., Amakawa, Y., Sasaki, H. & Sado, T.: A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.; Development 136, 139-146 (2009); PubMed

Nesterova, T.B., Popova, B.C., Cobb, B.S., Norton, S., Senner, C.E., Tang, Y.A., Spruce, T., Rodriguez, T.A. & Sado, T.: Merkenschlager M. and Brockdorff N. Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a.; Epigenetics & Chromatin 1:2 (2008); PubMed

Chiba, H., Hirasawa, R., Kaneda, M., Amakawa, Y., Li, E., Sado, T. & Sasaki, H.: De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes.; Genesis 46, 768-774 (2008); PubMed

Ohhata, T., Hoki, Y., Sasaki, H. & Sado, T.: Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification.; Development 135, 227-235 (2008); PubMed

Sado, T., Hoki, Y. & Sasaki, H.: Tsix defective in splicing is competent to establish Xist silencing.; Development 133(24): 4925-4931 (2006); PubMed

Ohhata, T., Hoki, Y., Sasaki, H. & Sado, T.: Tsix-deficent X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.; Cytogenet. Genome Res. 113 (Special Issue on Genomic Imprinting), 345-349 (2006); PubMed

Sado, T., Hoki, Y. & Sasaki, H.: Tsix silences Xist through modification of chromatin structure.; Dev. Cell 9, 159-165 (2005); PubMed

Kaneda, M., Sado, T., Okano, M., Hata, K., Tsujimoto, N., Li, E. & Sasaki, H.: Role of de novo DNA methyltransferases in initiation of genomic imprinting and X-chromosome inactivation.; Cold Spring Harbor Symp. Quant. Biol. 69, 125-129 (2004); PubMed

Purbowasito, W., Suda, C., Yokomine, T., Zubair, M., Sado, T., Tsutsui, K. & Sasaki, H.: Large-scale identification and mapping of nuclear matrix-attachment regions in the distal imprinted domain of mouse chromosome 7.; DNA Res. 11, 391-407 (2004); PubMed

Ohhata, T., Tachibana, M., Tada, M., Tada, T., Sasaki, H., Shinkai, Y. & Sado, T.: X-inactivation is stably maintained in mouse embryos deficient for histone methyltransferase G9a.; Genesis 40, 151-156 (2004); PubMed

Kaneda, M., Okano, M., Hata, K., Sado, T., Tsujimoto, N., Li, E. & Sasaki, H.: Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.; Nature 429, 900-903 (2004); PubMed

Sado, T., Okano, M., Li, E. & Sasaki, H.: De novo methylation is dispensable for the initiation and propagation of X chromosome inactivation.; Development 131, 957-982 (2004); PubMed

Sado, T., Li, E. & Sasaki, H.: Effect of Tsix-disruption on Xist expression in male ES cells.; Cytogenet. Genome Res. 99, 115-118 (2002); PubMed

Shirohzu, H., Kubota, T., Kumazawa, A., Sado, T., Chijiwa, T., Inagaki, K., Suetake, I., Tajima, S., Wakui, K., Miki, Y., Hayashi, M., Fukushima, Y. & Sasaki, H.: Three novel DNMT3B mutations in Japanese patients with ICF syndrome.; Am. J. Med. Genet. 112, 31-37 (2002); PubMed

Takebayashi, S., Nakao, M., Fujita, N., Sado, T., Tanaka, M., Taguchi, H. & Okumura, K.: 5-Aza-2-deoxycytidine induces histone hyperacetylation of mouse centromeric heterochromatin by a mechanism independent of DNA demethylation.; Biochem. Biophys. Res. Commun. 288, 921-926, (2001); PubMed

Sado, T., Wang, Z., Sasaki, H. & Li, E.: Regulation of imprinted X-chromosome inactivation in mice by Tsix.; Development 128, 1275-1286 (2001); PubMed

Grandjean, V., O'Neill, L., Sado, T., Turner, B. & Ferguson-Smith, A.: Relationship between DNA methylation, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H19 domain.; FEBS Lett. 488, 165-169 (2001); PubMed

Sado, T., Fenner, M. H., Tan, S-S., Tam, P., Shioda, T. & Li, E.: X-inactivation in the mouse embryo deficient for Dnmt1: Distinct effect of hypomethylation on imprinted and random X-inactivation.; Dev. Biol. 225, 294-303 (2000); PubMed

Nishita, Y., Sado, T., Yoshida, I. & Takagi, N.: Effect of CpG methylation on expression of mouse imprinted gene Mest.; Gene 226, 199-209 (1998); PubMed

Schuster-Gossler, K., Bilinski, P., Sado, T., Ferguson-Smith, A. & Gossler, A.: The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA.; Dev. Dyn. 212, 214-228 (1998); PubMed

Tada, T., Tada, M., Hilton, K., Barton, S. C., Sado, T., Takagi, N. & Surani, M. A.: Epigenotype switching of imprintable loci in embryonic germ cells.; Dev. Genes and Evol. 207, 551-561 (1998); PubMed

Nishita, Y., Yoshida, I., Sado, T. & Takagi, N.: Genomic imprinting and chromosomal localization of the human MEST gene.; Genomics 36, 539-542 (1996); PubMed

Mise, N., Sado, T., Tada, M., Takada, S. & Takagi, N.: Activation of the inactive X chromosome induced by cell fusion between a murine EC and female somatic cell accompanies reproducible changes in the methylation pattern of the Xist gene.; Exp. Cell Res.223, 193-202 (1996); PubMed

Sado, T., Tada, T. & Takagi, N.: Mosaic methylation of Xist gene before chromosome inactivation in undifferentiated female mouse embryonic stem and embryonic germ cells.; Dev. Dyn. 205, 421-434 (1996); PubMed

Nakajima, N. & Sado, T.: Nucleotide sequence of a mouse lamin A cDNA and its deduced amino acid sequence.; Biochim. Biophys. Acta. 1171, 311-314 (1993); PubMed

Sado, T., Nakajima, N., Tada, M. & Takagi, N.: A novel mesoderm-specific cDNA isolated from a mouse embryonal carcinoma cell line.; Dev. Growth and Differ. 35, 551-560 (1993)

Reviews

Nakajima, T. & Sado, T.: Current view of the potential roles of proteins enriched on the inactive X chromosome.; Genes Genet Syst. 89, 151-157 (2014); PubMed

Sado, T. & Sakaguchi, T.: Species-specific differences in X chromosome inactivation in mammals.; Reproduction 146, R131-R139 (2013); PubMed

Sado, T. & Brockdorff, N.: Advances in understanding chromosome silencing by the long non-coding RNA Xist.; Philos Trans R Soc Lond B Biol Sci. 368, (1609) 20110325 (2013); PubMed

Sado, T. & Ferguson-Smith, A. C.: Imprinted X inactivation and reprogramming in the preimplantation mouse embryo.; Hum. Mol. Genet. 14, Spec. 1, R59-64. (2005); PubMed

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Division of Epigenomics and Development, Department of Molecular and Structural Biology
Medical Institute of Bioregulation, Kyushu University
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