第770回 生医研セミナー(多階層生体防御システム研究拠点)

下記の通り、ロックフェラー大学の船引宏則教授によるセミナーを開催致します。

船引宏則教授は体細胞分裂における染色体動態研究の第一人者です。皆様のご来聴を心より歓迎いたします。
※セミナーは英語で行われます。(Seminar in English)

(本セミナーは生医研の共同利用・共同研究の共同研究型プロジェクトを利用しての招聘です)

演題 / Title

Regulations of mitotic processes by nucleosomes — molecular principles and implications in cancer biology and immunology

演者 / Speaker

船引 宏則 教授
Hironori Funabiki, Ph.D.
Laboratory of Chromosome and Cell Biology, The Rockefeller University

日時 / Date

2018年6月20日(水)  Jun. 20 (Wed), 2018
17:00~18:00

場所 / Venue

病院キャンパス 生体防御医学研究所 本館1階 会議室
以下の地図の31番です。
(http://www.kyushu-u.ac.jp/f/33270/2018hospital.pdf)

Seminar Room, Main Building 1F, Medical Institute of Bioregulation
No.31 on the following linked map.
(http://www.kyushu-u.ac.jp/f/33271/2018hospital-en.pdf)

要 旨 / Abstract

Chromosome structure and functions dramatically change during mitosis. Although the nucleosome is a fundamental structural and functional unit of eukaryotic chromatin, its regulatory roles in mitosis are poorly understood. Through comparative chromatin proteomics analysis to identify proteins whose chromatin binding is altered in mitosis, we discovered the novel nucleosome remodeling complex CHIRRC, composed of CDCA7 and HELLS, both of which are mutated in the Immunodeficiency, Centromere instability and Facial anomalies (ICF) syndrome. We also found that the cytoplasmic DNA sensor, cGAS, a critical component of the innate immune system, gains an access to mitotic chromosomes upon nuclear envelope break down, but its DNA-induced activation is suppressed by the nucleosome. However, when cells are arrested in mitosis by taxol, cGAS slowly becomes activated and promotes apoptosis. Implications of these findings in the ICF syndrome and cancers will be discussed.

参考文献 / References

Zierhut C., Jenness C., Kimura, H., and *Funabiki, H. (2014) Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion. Nat Struct Mol Biol, 21, 617-625.

Zierhut C. and Funabiki, H. (2017) The cytoplasmic DNA sensor cGAS promotes mitotic cell death. bioRxiv 168070; doi: https://doi.org/10.1101/168070

Jenness C, Giunta S, Muller MM, Kimura H, Muir TW, *Funabiki H. (2018) HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. (2018) Proc Natl Acad Sci U S A. 115, E876-E885.

連絡先 / Contact

生体防御医学研究所
エピゲノム制御学分野
鵜木 元香 092(642)6761

Motoko Unoki
Division of Epigenomics and Development, Medical Institute of Bioregulation
Tel:092(642)6761