The 760th MIB Seminar
(Joint Usage/Research Center for the Multi-stratified Host Defense System)
[Seminar in English]
Title
Ubiquitination in inflammation, cell death and autophagy
Speaker
Fumiyo Ikeda, Ph.D., D.D.S.
Group leader
Institute of Molecular Biotechnology (IMBA)
Date
Jan. 29 (Mon), 2018
11：30～12：30
Venue
Seminar Room, Main Building 1F, Medical Institute of Bioregulation
No.26 on the following linked map.
（http://www.kyushu-u.ac.jp/f/30074/Hospital_en-2017.pdf）
Abstract
Ubiquitin is a highly conserved small modifier protein, which regulates multitude of biological functions. We are interested in a mechanistic aspect how a non-degradation ubiquitin tag controls inflammation, cell death and autophagy. In this seminar, I will discuss about importance of a non-conventional type of ubiquitination.
Publications
- Ikeda, F. et al. SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature 471, 637-41 (2011)
- Kumari, S. et al. Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. eLife 3, e03422 (2014)
Contact
Medical Institute of Bioregulation
Yusaku Nakabeppu
Tel：092-642-6800