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class=\"wp-block-paragraph\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1494\" height=\"1004\" src=\"https:\/\/www.bioreg.kyushu-u.ac.jp\/labo\/ged\/wp\/wp-content\/uploads\/2025\/03\/TB-mechanism.png\" alt=\"\u56f32. \u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u5236\u5fa1\u6a5f\u69cb\" class=\"wp-image-1293\" style=\"width:691px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-a6817f02e7e65312ab2d8be051258500 wp-block-paragraph\"><strong><strong>\u56f32. \u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u5236\u5fa1\u6a5f\u69cb<\/strong><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u306e\u76ee\u7684<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u672c\u7814\u7a76\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u306f\u3001<strong>\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068<\/strong>\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u80cc\u666f\u306b\u3042\u308b\u5206\u5b50\u6a5f\u69cb\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3067\u3001\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u3084\u3086\u3089\u304e\uff08\u30ce\u30a4\u30ba\uff09\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b\u306e\u304b\u3092\u7406\u89e3\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u306f\u5358\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u57fa\u790e\u539f\u7406\u3092\u77e5\u308b\u3060\u3051\u3067\u306a\u304f\u3001\u540c\u3058\u907a\u4f1d\u7684\u80cc\u666f\u3092\u6301\u3064\u7d30\u80de\u96c6\u56e3\u306e\u4e2d\u3067\u751f\u3058\u308b<strong>\u907a\u4f1d\u5b50\u767a\u73fe\u91cf\u306e\u3070\u3089\u3064\u304d<\/strong>\u3092\u8aac\u660e\u3059\u308b\u624b\u304c\u304b\u308a\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u7d30\u80de\u9593\u306e\u767a\u73fe\u3070\u3089\u3064\u304d\u306f\u3001<strong>\u7d30\u80de\u904b\u547d\u306e\u6c7a\u5b9a<\/strong>\u3084\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u306a\u3069\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u91cd\u8981\u306a\u8981\u56e0\u3067\u3059\u3002\u4f8b\u3048\u3070\u3001\u672a\u5206\u5316\u306a\u5e79\u7d30\u80de\u96c6\u56e3\u306e\u4e2d\u3067\u3001\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u9055\u3044\u306b\u3088\u3063\u3066\u4e00\u90e8\u306e\u7d30\u80de\u3060\u3051\u304c\u5206\u5316\u306e\u30b9\u30a4\u30c3\u30c1\u3068\u306a\u308b\u907a\u4f1d\u5b50\u3092\u767a\u73fe\u3057\u3001\u4ed6\u306f\u672a\u5206\u5316\u306e\u307e\u307e\u7dad\u6301\u3055\u308c\u308b\u3001\u3068\u3044\u3063\u305f\u73fe\u8c61\u304c\u8d77\u3053\u308a\u3048\u307e\u3059\u3002\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u3001<strong>\u7d30\u80de\u306e\u72b6\u614b\u9077\u79fb\u3084\u904b\u547d\u6c7a\u5b9a\u3092\u4e88\u6e2c\u30fb\u5236\u5fa1<\/strong>\u3059\u308b\u4e0a\u3067\u3082\u610f\u7fa9\u304c\u6df1\u304f\u3001\u767a\u751f\u751f\u7269\u5b66\u304b\u3089\u518d\u751f\u533b\u7642\u307e\u3067\u5e45\u5e83\u3044\u5206\u91ce\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u907a\u4f1d\u7684\u306b\u540c\u4e00\u306a\u7d30\u80de\u3067\u3082\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306b\u3088\u308b\u3086\u3089\u304e\u304c\u3042\u308b\u304a\u304b\u3052\u3067\u3001\u591a\u7d30\u80de\u751f\u7269\u3067\u306f\u74b0\u5883\u5909\u5316\u306b\u5bfe\u3059\u308b\u9069\u5fdc\u529b\u304c\u5897\u3057\u3001\u500b\u4f53\u306e\u5065\u5168\u6027\u304c\u4fdd\u305f\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u5074\u9762\u3082\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u4e00\u65b9\u3067\u3001\u3053\u306e\u3086\u3089\u304e\u304c\u904e\u5270\u306b\u306a\u308b\u3068\u7d44\u7e54\u306e\u6a5f\u80fd\u4e0d\u5168\u3084\u75be\u60a3\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u305d\u306e<strong>\u9069\u5207\u306a\u30d0\u30e9\u30f3\u30b9\u3092\u4fdd\u3064\u4ed5\u7d44\u307f<\/strong>\u3092\u89e3\u304d\u660e\u304b\u3059\u3053\u3068\u304c\u672c\u7814\u7a76\u306e\u76ee\u7684\u3067\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u624b\u6cd5<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u3068\u3044\u3046\u8907\u96d1\u306a\u73fe\u8c61\u306b\u8feb\u308b\u305f\u3081\u306b\u3001\u5f53\u7814\u7a76\u5ba4\u3067\u306f<strong>\u30de\u30eb\u30c1\u30b9\u30b1\u30fc\u30eb\u304b\u3064\u30de\u30eb\u30c1\u30e2\u30fc\u30c0\u30eb<\/strong>\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u53d6\u3063\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u4ee5\u4e0b\u306e\u6700\u5148\u7aef\u624b\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u3067\u3001\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u767a\u751f\u304b\u3089\u5236\u5fa1\u307e\u3067\u3092\u5305\u62ec\u7684\u306b\u89e3\u6790\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30e9\u30a4\u30d6\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0<\/strong>: \u751f\u304d\u305f\u7d30\u80de\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u89b3\u5bdf\u3057\u3001\u907a\u4f1d\u5b50\u306e\u8ee2\u5199ON\/OFF\u306e\u5207\u308a\u66ff\u308f\u308a\uff08\u30d0\u30fc\u30b9\u30c8\u767a\u751f\uff09\u3092\u76f4\u63a5\u53ef\u8996\u5316\u3057\u307e\u3059\u3002\u86cd\u5149\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30dd\u30fc\u30bf\u30fc\u3084\u751f\u4f53\u5185\u6a19\u8b58\u6280\u8853\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u79d2\uff5e\u5206\u5358\u4f4d\u306e\u8ee2\u5199\u30c0\u30a4\u30ca\u30df\u30af\u30b9\u3092\u8ffd\u8de1\u3057\u3001\u30d0\u30fc\u30b9\u30c8\u306e\u983b\u5ea6\u3084\u6301\u7d9a\u6642\u9593\u3092\u5b9a\u91cf\u5316\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"youtube\"><iframe title=\"STREAMING-tag system\" src=\"https:\/\/www.youtube.com\/embed\/MrUqTxu-VRY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-b0f3f48468a165e2df93cc6e0d180b85 wp-block-paragraph\"><strong>\u5358\u4e00\u907a\u4f1d\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853(STREAMING-tag\u30b7\u30b9\u30c6\u30e0)\u306e\u6a21\u5f0f\u56f3\u3068\u672c\u6280\u8853\u3092\u5229\u7528\u3057\u3066\u64ae\u5f71\u3055\u308c\u305f\u52d5\u753b\u3002<\/strong>\u30de\u30a6\u30b9ES\u7d30\u80de\u306e<em>Nanog<\/em>\u907a\u4f1d\u5b50\u306bSTREAMING-tag\u304c\u9069\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u672c\u7d30\u80de\u309215\u79d2\u9593\u9694\u3067\u64ae\u5f71\u3057\u305f\u52d5\u753b\u3002<br><br><br><\/p>\n<\/div>\n<\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"youtube\"><iframe title=\"STREAMING-tag system (long time-lapse)\" src=\"https:\/\/www.youtube.com\/embed\/cIPwzd5pGMw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-f75a186fdfd40e40353d1926d8bdbd89 wp-block-paragraph\"><strong>\u5358\u4e00\u907a\u4f1d\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853(STREAMING-tag\u30b7\u30b9\u30c6\u30e0)\u306e\u6a21\u5f0f\u56f3\u3068\u672c\u6280\u8853\u3092\u5229\u7528\u3057\u3066\u64ae\u5f71\u3055\u308c\u305f\u52d5\u753b\u3002<\/strong>\u30de\u30a6\u30b9ES\u7d30\u80de\u306e<em>Nanog<\/em>\u907a\u4f1d\u5b50\u306bSTREAMING-tag\u304c\u9069\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u672c\u7d30\u80de\u30922\u5206\u9593\u9694\u3067\u64ae\u5f71\u3057\u305f\u52d5\u753b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5358\u4e00\u5206\u5b50\u86cd\u5149\u00a0<em>in situ<\/em>\u00a0\u30cf\u30a4\u30d6\u30ea\u30c0\u30a4\u30bc\u30fc\u30b7\u30e7\u30f3\uff08smFISH\uff09<\/strong>: \u56fa\u5b9a\u3057\u305f\u7d30\u80de\u5185\u3067<strong>\u5358\u4e00\u5206\u5b50\u30ec\u30d9\u30eb\u306emRNA<\/strong>\u3092\u691c\u51fa\u3059\u308b\u624b\u6cd5\u3067\u3059\u3002\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u7523\u7269\u3092\u4e00\u672c\u4e00\u672c\u6570\u3048\u308b\u3053\u3068\u3067\u3001\u5404\u7d30\u80de\u304c\u6301\u3064mRNA\u5206\u5b50\u6570\u306e\u5206\u5e03\u3092\u6e2c\u5b9a\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u7d50\u679c\u751f\u3058\u308b\u767a\u73fe\u91cf\u306e\u3086\u3089\u304e\u3092\u9759\u7684\u306a\u30b9\u30ca\u30c3\u30d7\u30b7\u30e7\u30c3\u30c8\u3068\u3057\u3066\u6349\u3048\u3001\u7d30\u80de\u9593\u306e\u3070\u3089\u3064\u304d\u3092\u53ef\u8996\u5316\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"673\" height=\"341\" src=\"https:\/\/www.bioreg.kyushu-u.ac.jp\/labo\/ged\/wp\/wp-content\/uploads\/2021\/02\/\u8ee2\u5199\u30d0\u30fc\u30b9\u30c83_\u30a2\u30a4\u30ad\u30e3\u30c3\u30c1-1.png\" alt=\"smFISH\u306b\u3088\u3063\u3066\u3001\u30de\u30a6\u30b9ES\u7d30\u80de\u306eNanog mRNA\u3092\u7dd1\u8272\u86cd\u5149\u8272\u7d20\u3067\u67d3\u8272\u3057\u305f\u753b\u50cf\u3002\u9752\u8272\u306f\u7d30\u80de\u6838\u3092\u793a\u3059\u3002\u77e2\u982d\u306f\u3001\u307e\u3055\u306b\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u907a\u4f1d\u5b50\u9818\u57df(\u8ee2\u5199\u8f1d\u70b9)\u3092\u793a\u3059\u3002\" class=\"wp-image-104\" style=\"width:507px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-9234f066f79ad061266d65275d47b829 wp-block-paragraph\">smFISH\u306b\u3088\u3063\u3066\u3001\u30de\u30a6\u30b9ES\u7d30\u80de\u306e<em>Nanog<\/em> mRNA\u3092\u7dd1\u8272\u86cd\u5149\u8272\u7d20\u3067\u67d3\u8272\u3057\u305f\u753b\u50cf\u3002\u9752\u8272\u306f\u7d30\u80de\u6838\u3092\u793a\u3059\u3002\u77e2\u982d\u306f\u3001\u307e\u3055\u306b\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u907a\u4f1d\u5b50\u9818\u57df(\u8ee2\u5199\u8f1d\u70b9)\u3092\u793a\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u30de\u30eb\u30c1\u30e2\u30fc\u30c0\u30ebseqFISH\uff08DNA\/RNA\/IF-FISH\uff09<\/strong>:\u00a0<strong>DNA\u30fbRNA\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u540c\u6642\u306b\u53ef\u8996\u5316\u3067\u304d\u308b\u9ad8\u5ea6\u306a\u9010\u6b21FISH\u6cd5<\/strong>\u3067\u3059\u200b\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u7d30\u80de\u5185\u306e\u7279\u5b9a\u306e<strong>\u30b2\u30ce\u30e0DNA\u9818\u57df<\/strong>\uff08\u4f8b\uff1a\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u3084\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\uff09\u3001\u5bfe\u5fdc\u3059\u308b<strong>RNA\u8ee2\u5199\u7523\u7269<\/strong>\u3001\u304a\u3088\u3073<strong>\u8ee2\u5199\u56e0\u5b50\u306a\u3069\u306e\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u514d\u75ab\u67d3\u8272, IF\uff09\u3092\u9806\u756a\u306b\u86cd\u5149\u6a19\u8b58\u3057\u3001\u540c\u4e00\u7d30\u80de\u5185\u3067\u7a7a\u9593\u7684\u306b\u91cd\u306d\u5408\u308f\u305b\u3066\u89b3\u5bdf\u3057\u307e\u3059\u200b\u3002\u3053\u306e\u624b\u6cd5\u306b\u3088\u308a\u3001\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u304c\u8d77\u304d\u3066\u3044\u308b\u907a\u4f1d\u5b50\u5ea7\u306e\u8fd1\u508d\u3067\u8d77\u3053\u308bDNA\u69cb\u9020\u5909\u5316<\/strong>\uff08\u9818\u57df\u9593\u8ddd\u96e2\u306e\u5909\u5316\uff09\u3084<strong>\u8abf\u7bc0\u56e0\u5b50\u306e\u5c40\u6240\u84c4\u7a4d<\/strong>\u3092\u53ef\u8996\u5316\u3057\u3001\u7a7a\u9593\u7684\u30b3\u30f3\u30c6\u30af\u30b9\u30c8\u304b\u3089\u30d0\u30fc\u30b9\u30c8\u5236\u5fa1\u306e\u4ed5\u7d44\u307f\u306b\u8feb\u308a\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1670\" height=\"804\" src=\"https:\/\/www.bioreg.kyushu-u.ac.jp\/labo\/ged\/wp\/wp-content\/uploads\/2025\/03\/image-3.png\" alt=\"DNA\/RNA\/IF-seqFISH\u306e\u6a21\u5f0f\u56f3\u3002\" class=\"wp-image-1297\" style=\"width:600px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-6ed9e9e4a362a1d6ad0f426bdab37137 wp-block-paragraph\">DNA\/RNA\/IF-seqFISH\u306e\u6a21\u5f0f\u56f3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"youtube\"><iframe title=\"seqFISH\" src=\"https:\/\/www.youtube.com\/embed\/PbJDknSxyBo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-c3721aaba53c02b8954e134921cea580 wp-block-paragraph\">seq-DNA\/RNA\/IF-FISH\u306e\u4ee3\u8868\u7684\u306a\u753b\u50cf\u3002\u672c\u52d5\u753b\u306f\u3001seq-DNA\/RNA-IF-FISH\u3092\u7528\u3044\u3066\u5404\u30e9\u30a6\u30f3\u30c9\u3067\u53d6\u5f97\u3055\u308c\u305f\u753b\u50cf\u306e\u6700\u5927\u8f1d\u5ea6\u6295\u5f71\u304b\u3089\u4f5c\u6210\u3055\u308c\u3066\u3044\u308b\u3002\u5404\u30e9\u30a6\u30f3\u30c9\u306b\u304a\u3044\u3066\u30013\u7a2e\u985e\u306e\u4e8c\u6b21\u30d7\u30ed\u30fc\u30d6\u30bb\u30c3\u30c8\u304a\u3088\u3073\u8aad\u307f\u53d6\u308a\u30d7\u30ed\u30fc\u30d6\u30bb\u30c3\u30c8\u304c\u4f7f\u7528\u3055\u308c\u30013\u3064\u306e\u30c1\u30e3\u30f3\u30cd\u30eb\u3092\u4ecb\u3057\u305f\u753b\u50cf\u53d6\u5f97\u304c\u53ef\u80fd\u3067\u3042\u3063\u305f\u3002\u305d\u308c\u305e\u308c\u306e\u30c1\u30e3\u30f3\u30cd\u30eb\u306f\u5358\u4e00\u306eRNA\u3001\u30b2\u30ce\u30e0\u9818\u57df\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u307e\u305f\u306f\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306e\u5c40\u5728\u3092\u89b3\u5bdf\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u3053\u308c\u3089\u306e\u624b\u6cd5\u304b\u3089\u5f97\u3089\u308c\u308b\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u6319\u52d5\u3092\u6570\u7406\u30e2\u30c7\u30eb\u5316\u3059\u308b\u8a66\u307f\u3082\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u4f8b\u3048\u3070\u3001\u30d0\u30fc\u30b9\u30c8\u767a\u751f\u3092\u4e8c\u72b6\u614b\uff08\u30aa\u30f3\u30fb\u30aa\u30d5\uff09\u30e2\u30c7\u30eb\u3084\u78ba\u7387\u904e\u7a0b\u3068\u3057\u3066\u30e2\u30c7\u30eb\u5316\u3057\u3001\u5b9f\u6e2c\u30c7\u30fc\u30bf\u3068\u306e\u30d5\u30a3\u30c3\u30c6\u30a3\u30f3\u30b0\u304b\u3089\u5236\u5fa1\u30d1\u30e9\u30e1\u30fc\u30bf\u3092\u63a8\u5b9a\u3057\u307e\u3059\u3002\u3053\u3046\u3057\u305f<strong>\u5b9f\u9a13\u3068\u8a08\u7b97\u306e\u4e21\u9762<\/strong>\u304b\u3089\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u308a\u3001\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u73fe\u8c61\u3092\u591a\u89d2\u7684\u306b\u89e3\u660e\u3057\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u95a2\u9023\u7814\u7a76\u304a\u3088\u3073\u6210\u679c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3000\u5f53\u7814\u7a76\u5ba4\u306f<strong>\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u7814\u7a76\u306e\u6700\u524d\u7dda<\/strong>\u3067\u6210\u679c\u3092\u767a\u4fe1\u3057\u3066\u3044\u307e\u3059\u3002\u4ee5\u4e0b\u306b\u3001\u6700\u8fd1\u306e\u4e3b\u306a\u7814\u7a76\u6210\u679c\uff08\u8ad6\u6587\uff09\u306e\u4e00\u90e8\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aaz6699\" target=\"_blank\" rel=\"noreferrer noopener\">Ochiai, H.\u00a0<em>et al.<\/em>\u00a0Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells.<strong>\u00a0<em>Sci Adv<\/em>\u00a0<\/strong>6, eaaz6699 (2020)<\/a><strong>.<\/strong>\u00a0\u2013 \u30de\u30a6\u30b9\u80da\u6027\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u89e3\u6790\u306b\u3088\u308a\u3001<strong>\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u5927\u304d\u3055\u3084\u983b\u5ea6\uff08\u52d5\u7684\u7279\u6027\uff09\u304c\u7279\u5b9a\u306e\u56e0\u5b50\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b<\/strong>\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u3084\u907a\u4f1d\u5b50\u672c\u4f53\u306b\u7d50\u5408\u3059\u308b<strong>\u30dd\u30ea\u30b3\u30fc\u30e0\u8907\u5408\u4f53\u3084\u8ee2\u5199\u4f38\u9577\u56e0\u5b50<\/strong>\u304c\u30d0\u30fc\u30b9\u30c8\u52d5\u614b\u3092\u6c7a\u5b9a\u3057\u3046\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u200b\u3001\u3055\u3089\u306bCRISPR\u30b9\u30af\u30ea\u30fc\u30f3\u306b\u3088\u3063\u3066<strong>Akt\/MAPK\u30b7\u30b0\u30ca\u30eb\u7d4c\u8def<\/strong>\u304c\u8ee2\u5199\u4f38\u9577\u52b9\u7387\u306e\u8abf\u7bc0\u3092\u4ecb\u3057\u3066\u30d0\u30fc\u30b9\u30c8\u6319\u52d5\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3082\u7a81\u304d\u6b62\u3081\u3066\u3044\u307e\u3059\u200b\u3002\u3053\u308c\u3089\u306e\u6210\u679c\u306f\u3001\u54fa\u4e73\u985e\u7d30\u80de\u306b\u304a\u3051\u308b\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u30ce\u30a4\u30ba\u306e<strong>\u4e3b\u8981\u306a\u5206\u5b50\u6a5f\u69cb<\/strong>\u3092\u89e3\u660e\u3057\u305f\u3082\u306e\u3067\u3059\u3002<br><\/li>\n\n\n\n<li><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.adn0020\" target=\"_blank\" rel=\"noreferrer noopener\">Ohishi, H.\u00a0<em>et al.<\/em>\u00a0Transcription-coupled changes in genomic region proximities during transcriptional bursting.<strong>\u00a0<em>Sci. Adv.<\/em><\/strong>10, eadn0020 (2024).<\/a>\u00a0\u2013\u00a0<strong>\u30a8\u30f3\u30cf\u30f3\u30b5\u30fc\u3068\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9593\u306e\u8ddd\u96e2\u5909\u5316<\/strong>\u304c\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u7dad\u6301\u30fb\u5b89\u5b9a\u5316\u306b\u5bc4\u4e0e\u3059\u308b\u65b0\u305f\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u5148\u9032\u7684\u306a<strong>seq-DNA\/RNA\/IF-FISH\u6cd5<\/strong>\u3092\u99c6\u4f7f\u3057\u3001\u907a\u4f1d\u5b50\u304c\u6d3b\u767a\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u72b6\u6cc1\u3067\u306f\u5468\u8fba\u306e\u7279\u5b9aDNA\u9818\u57df\u304c\u8fd1\u63a5\u3057\u3066<strong>\u8ee2\u5199\u95a2\u9023\u56e0\u5b50\u304c\u5c40\u6240\u7684\u306b\u96c6\u7a4d\u3059\u308b<\/strong>\u73fe\u8c61\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u200b\u3002\u3053\u306e\u56e0\u5b50\u96c6\u7a4d\u306b\u3088\u3063\u3066\u907a\u4f1d\u5b50\u767a\u73fe\u304c\u4fc3\u9032\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001<strong>\u30b2\u30ce\u30e0\u306e\u7acb\u4f53\u69cb\u9020<\/strong>\u304c\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u52d5\u7684\u5236\u5fa1\u306b\u679c\u305f\u3059\u5f79\u5272\u306b\u3064\u3044\u3066\u65b0\u305f\u306a\u8996\u70b9\u3092\u63d0\u4f9b\u3057\u305f\u6210\u679c\u3067\u3059\u200b\u3002<br><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41467-022-35286-2\" target=\"_blank\" rel=\"noreferrer noopener\">Ohishi, H.\u00a0<em>et al.<\/em>\u00a0STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity.\u00a0<strong><em>Nat Commun<\/em>\u00a0<\/strong>13, 7672 (2022).<\/a>\u00a0\u2013 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