{"id":94,"date":"2021-02-05T16:11:35","date_gmt":"2021-02-05T07:11:35","guid":{"rendered":"https:\/\/home.hiroshima-u.ac.jp\/ochiai\/?page_id=94"},"modified":"2025-03-20T09:34:06","modified_gmt":"2025-03-20T00:34:06","slug":"gene-expression-heterogeneity-and-cell-fate-decisions-jp","status":"publish","type":"page","link":"https:\/\/www.bioreg.kyushu-u.ac.jp\/labo\/ged\/gene-expression-heterogeneity-and-cell-fate-decisions-jp","title":{"rendered":"\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u591a\u69d8\u6027\u304c\u7d30\u80de\u904b\u547d\u6c7a\u5b9a\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306e\u89e3\u660e"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u30a4\u30f3\u30c8\u30ed\u30c0\u30af\u30b7\u30e7\u30f3<\/h2>\n\n\n\n<p>\u3000\u7d30\u80de\u904b\u547d\u6c7a\u5b9a\u3068\u306f\u3001\u7d30\u80de\u304c\u7279\u5b9a\u306e\u6027\u8cea\u3084\u5f79\u5272\u3092\u7372\u5f97\u3057\u3066\u3044\u304f\u30d7\u30ed\u30bb\u30b9\u306e\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u672a\u5206\u5316\u306a\u7d30\u80de\u304c\u7279\u5b9a\u306e\u7d30\u80de\u7cfb\u8b5c\u3078\u3068\u6210\u719f\u3059\u308b\u300c\u7d30\u80de\u5206\u5316\u300d\u3060\u3051\u3067\u306a\u304f\u3001\u7d30\u80de\u306e\u751f\u5b58\u3084\u6b7b\uff08\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\uff09\u3001\u7d30\u80de\u306e\u79fb\u52d5\u3084\u914d\u7f6e\u306e\u5909\u5316\u306a\u3069\u3001\u591a\u69d8\u306a\u73fe\u8c61\u3092\u542b\u3080\u5e83\u7fa9\u306e\u6982\u5ff5\u3067\u3059\u3002\u540c\u3058\u30b2\u30ce\u30e0\u3084\u74b0\u5883\u3092\u6301\u3064\u7d30\u80de\u96c6\u56e3\u3067\u3042\u3063\u3066\u3082\u3001\u305d\u308c\u305e\u308c\u306e\u7d30\u80de\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u91cf\u306b\u306f\u3070\u3089\u3064\u304d\uff08\u591a\u69d8\u6027\uff09\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u3053\u306e\u4e00\u904e\u6027\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u3086\u3089\u304e\u304c\u3001\u7d30\u80de\u304c\u5c06\u6765\u7684\u306b\u305f\u3069\u308b\u904b\u547d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u767a\u751f\u904e\u7a0b\u306b\u304a\u3044\u3066\u306f\u3001\u3053\u3046\u3057\u305f\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u3086\u3089\u304e\u304c\u3001\u7d30\u80de\u306e\u5206\u5316\u3060\u3051\u3067\u306a\u304f\u3001\u30d7\u30ed\u30b0\u30e9\u30e0\u7d30\u80de\u6b7b\u3084\u7d30\u80de\u306e\u79fb\u52d5\u3092\u3082\u6c7a\u5b9a\u3059\u308b\u91cd\u8981\u306a\u8981\u7d20\u3068\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3000\u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u591a\u69d8\u6027\u3092\u751f\u307f\u51fa\u3059\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u4e00\u3064\u306b\u3001<strong>\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8<\/strong>\u304c\u3042\u308a\u307e\u3059\u3002\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u3068\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\uff08\u8ee2\u5199\uff09\u6d3b\u52d5\u304c<strong>ON\u72b6\u614b<\/strong>\uff08\u6d3b\u767a\u306bRNA\u5408\u6210\uff09\u3068<strong>OFF\u72b6\u614b<\/strong>\uff08\u307b\u3068\u3093\u3069RNA\u5408\u6210\u3057\u306a\u3044\uff09\u306e\u9593\u3092\u78ba\u7387\u7684\u306b\u5207\u308a\u66ff\u308f\u308b\u73fe\u8c61\u3067\u3059\u200b\u3002\u5404\u907a\u4f1d\u5b50\u306f\u7d30\u80de\u5185\u306b1\u301c2\u30b3\u30d4\u30fc\u3057\u304b\u306a\u3044\u305f\u3081\u3001ON\/OFF\u306e\u5207\u308a\u66ff\u3048\u306b\u3088\u3063\u3066\u751f\u3058\u308bRNA\u7523\u751f\u306e\u3086\u3089\u304e\u304c\u7d30\u80de\u9593\u3067\u5927\u304d\u306a\u767a\u73fe\u91cf\u306e\u3070\u3089\u3064\u304d\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u200b(<strong>\u56f31<\/strong>)\u3002\u3053\u306e\u3088\u3046\u306a\u8ee2\u5199\u306e\u4e0d\u5747\u4e00\u6027\uff08<strong>\u30ce\u30a4\u30ba<\/strong>\uff09\u304c\u7d30\u80de\u904b\u547d\u6c7a\u5b9a\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u300c\u78ba\u7387\u7684\u306a\u8ee2\u5199\u6d3b\u6027\u304c\u6c7a\u5b9a\u8ad6\u7684\u306a\u767a\u751f\u904e\u7a0b\u3092\u5c0e\u304f\u300d\u73fe\u8c61\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u200b\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"2048\" height=\"584\" src=\"https:\/\/www.bioreg.kyushu-u.ac.jp\/labo\/ged\/wp\/wp-content\/uploads\/2025\/03\/TB-noise-2048x584.png\" alt=\"\u56f31. \u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u3068\u305d\u308c\u306b\u3088\u3063\u3066\u8a98\u5f15\u3055\u308c\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u91cf\u306e\u591a\u69d8\u6027. (A)\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u6a21\u5f0f\u56f3. (B)\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u6709\u7121\u306b\u3088\u308b\u7d4c\u6642\u7684mRNA\u767a\u73fe\u91cf\u306e\u5909\u52d5. (C)\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306b\u3088\u3063\u3066\u30a2\u30ec\u30eb\u9593\u304a\u3088\u3073\u7d30\u80de\u9593\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u91cf\u306e\u5dee\u304c\u751f\u3058\u5f97\u308b.\" class=\"wp-image-1304\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-0de3e3a17350d120df0937bb26e03596\"><strong>\u56f31. \u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u3068\u305d\u308c\u306b\u3088\u3063\u3066\u8a98\u5f15\u3055\u308c\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u91cf\u306e\u591a\u69d8\u6027. <\/strong>(A)\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u6a21\u5f0f\u56f3. (B)\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u6709\u7121\u306b\u3088\u308b\u7d4c\u6642\u7684mRNA\u767a\u73fe\u91cf\u306e\u5909\u52d5. (C)\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306b\u3088\u3063\u3066\u30a2\u30ec\u30eb\u9593\u304a\u3088\u3073\u7d30\u80de\u9593\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u91cf\u306e\u5dee\u304c\u751f\u3058\u5f97\u308b.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u306e\u80cc\u666f<\/h2>\n\n\n\n<p>\u3000\u30de\u30a6\u30b9\u521d\u671f\u80da\u306e<strong>\u5185\u90e8\u7d30\u80de\u584a\u306f\u3001\u80da\u76e4\u80de\u671f\u306b\u80da\u5185\u90e8\u306b\u5b58\u5728\u3059\u308b\u672a\u5206\u5316\u7d30\u80de\u306e\u96c6\u56e3\u3067\u3001\u3053\u306e\u5185\u90e8\u7d30\u80de\u584a\u304b\u3089\u5c06\u6765\u7684\u306b\u80da\u4f53\u3092\u5f62\u6210\u3059\u308b\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u3068\u3001\u80da\u4f53\u5916\u7d44\u7e54\u3068\u306a\u308b\u539f\u59cb\u5185\u80da\u8449\u304c\u5206\u5316\u3057\u307e\u3059\u200b\u3002\u5185\u90e8\u7d30\u80de\u584a\u7d30\u80de\u3067\u306f\u767a\u751f\u521d\u671f\u306b\u304a\u3044\u3066\u3001\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u5206\u5316\u3092\u793a\u3059\u8ee2\u5199\u56e0\u5b50NANOG<\/strong>\u3068\u5185\u90e8\u7d30\u80de\u584a\u5206\u5316\u3092\u793a\u3059\u8ee2\u5199\u56e0\u5b50<strong>GATA6<\/strong>\u306e\u4e21\u65b9\u3092\u3059\u3079\u3066\u306e\u7d30\u80de\u304c\u5171\u767a\u73fe\u3057\u3066\u3044\u307e\u3059\u200b\u3002\u80da\u306e\u767a\u751f\u304c\u9032\u3080\u306b\u3064\u308c\u3066\u5185\u90e8\u7d30\u80de\u584a\u5185\u306e\u5404\u7d30\u80de\u306f\u6b21\u7b2c\u306bNANOG\u307e\u305f\u306fGATA6\u306e\u3044\u305a\u308c\u304b\u3092\u9ad8\u767a\u73fe\u3059\u308b\u72b6\u614b\u3078\u3068\u5206\u304b\u308c\uff08\u3044\u308f\u3086\u308b\u201c\u5869\u3068\u30b3\u30b7\u30e7\u30a6\u201d\u69d8\u306e\u30e2\u30b6\u30a4\u30af\u30d1\u30bf\u30fc\u30f3\u5f62\u6210\uff09\u3001\u6700\u7d42\u7684\u306bNANOG\u967d\u6027\u7d30\u80de\u306f\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u306b\u3001GATA6\u967d\u6027\u7d30\u80de\u306f\u539f\u59cb\u5185\u80da\u8449\u3078\u3068\u5206\u5316\u3057\u307e\u3059(<strong>\u56f32<\/strong>)\u3002\u3053\u306e\u5206\u5316\u30d7\u30ed\u30bb\u30b9\u306f\u4e00\u898b\u30e9\u30f3\u30c0\u30e0\u306b\u8d77\u3053\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u304c\u3001\u5b9f\u969b\u306b\u306fNANOG\u9ad8\u767a\u73fe\u306e\u5185\u90e8\u7d30\u80de\u584a\u7d30\u80de\u306f\u5c06\u6765\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u306b\u306a\u308b\u50be\u5411\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u200b\u3002\u307e\u305f\u3001NANOG\u9ad8\u767a\u73fe\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u308bFGF4\u30b7\u30b0\u30ca\u30eb\u304c\u5468\u56f2\u306e\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3001\u305d\u308c\u3089\u3092\u5185\u90e8\u7d30\u80de\u584a\u3078\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u6700\u7d42\u7684\u306a\u7d30\u80de\u7a2e\u306e\u5206\u96e2\uff08\u30bd\u30fc\u30c6\u30a3\u30f3\u30b0\uff09\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u200b\u3002\u3053\u306e\u3088\u3046\u306b<strong>\u5185\u90e8\u7d30\u80de\u584a\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u591a\u69d8\u6027<\/strong>\uff08NANOG\u3084GATA6\u306e\u767a\u73fe\u91cf\u306e\u7d30\u80de\u9593\u5dee\u7570\uff09\u306f\u3001\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u30fb\u539f\u59cb\u5185\u80da\u8449\u305d\u308c\u305e\u308c\u306e\u7d30\u80de\u904b\u547d\u3092\u6c7a\u5b9a\u3065\u3051\u308b\u91cd\u8981\u306a\u8981\u56e0\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059(<strong>\u56f32<\/strong>)\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1661\" height=\"961\" src=\"https:\/\/www.bioreg.kyushu-u.ac.jp\/labo\/ged\/wp\/wp-content\/uploads\/2025\/03\/TB-mouse-1.jpg\" alt=\"\u56f32. \u30de\u30a6\u30b9\u521d\u671f\u767a\u751f\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u30ec\u30d9\u30eb\u306e\u4e0d\u5747\u4e00\u6027\" class=\"wp-image-1309\" style=\"width:678px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-6007dc26c458217b5d05205de73b77f4\"><strong>\u56f32. \u30de\u30a6\u30b9\u521d\u671f\u767a\u751f\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u30ec\u30d9\u30eb\u306e\u4e0d\u5747\u4e00\u6027<\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u3000\u3057\u304b\u3057\u3001\u5185\u90e8\u7d30\u80de\u584a\u5185\u90e8\u3067\u6700\u521d\u306bNANOG\u3084GATA6\u306e\u767a\u73fe\u91cf\u306b\u3070\u3089\u3064\u304d\u304c\u751f\u3058\u308b\u4ed5\u7d44\u307f\u306b\u3064\u3044\u3066\u306f\u672a\u3060\u660e\u3089\u304b\u3067\u306a\u3044\u70b9\u304c\u591a\u304f\u6b8b\u3055\u308c\u3066\u3044\u307e\u3059\u200b\u3002\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u3001<em>Nanog<\/em>\u907a\u4f1d\u5b50\u306f\u30de\u30a6\u30b9\u521d\u671f\u80da\u304a\u3088\u3073ES\u7d30\u80de\u306b\u304a\u3044\u3066<strong>\u4e00\u65b9\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u304b\u3089\u306e\u307f\u8ee2\u5199\u3055\u308c\u308b\u5834\u5408\u304c\u3057\u3070\u3057\u3070\u3042\u308b<\/strong>\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u200b\u3002\u3053\u308c\u306f<em>Nanog<\/em>\u907a\u4f1d\u5b50\u304c\u9855\u8457\u306a\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u3092\u793a\u3059\u3053\u3068\u3092\u610f\u5473\u3057\u3001NANOG\u767a\u73fe\u91cf\u306e\u7d30\u80de\u9593\u591a\u69d8\u6027\uff08\u7d30\u80de\u3054\u3068\u306eNANOG\u91cf\u306e\u3070\u3089\u3064\u304d\uff09\u3092\u751f\u307f\u51fa\u3059\u4e00\u56e0\u306b\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u200b\u3002\u6211\u3005\u306e\u5148\u884c\u7814\u7a76\u3067\u3082\u3001\u30de\u30a6\u30b9ES\u7d30\u80de\u306b\u304a\u3044\u3066\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u7531\u6765\u306e<strong>intrinsic noise<\/strong>\uff08\u7d30\u80de\u5185\u8981\u56e0\u306b\u3088\u308b\u767a\u73fe\u3086\u3089\u304e\uff09\u304c<em>Nanog<\/em>\u767a\u73fe\u91cf\u306e\u7570\u8cea\u6027\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f (<a href=\"https:\/\/www.nature.com\/articles\/srep07125\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Ochiai<\/strong> et al., <strong><em>Sci Rep<\/em><\/strong>, 2014<\/a>; <a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aaz6699\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Ochiai<\/strong> et al., <strong><em>Sci Adv<\/em><\/strong>, 2020<\/a>)\u200b\u3002\u4e00\u65b9\u3067\u3001<strong>\u521d\u671f\u80da\u5185\u90e8\u7d30\u80de\u584a\u306b\u304a\u3044\u3066\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u304c\u5b9f\u969b\u306b\u3069\u306e\u7a0b\u5ea6\u767a\u751f\u3057\u3001\u305d\u308c\u304c\u7d30\u80de\u904b\u547d\u306e\u9078\u629e\u306b\u3069\u3046\u7d50\u3073\u3064\u304f\u306e\u304b<\/strong>\u306b\u3064\u3044\u3066\u306f\u3001\u76f4\u63a5\u7684\u306a\u691c\u8a3c\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u5185\u90e8\u7d30\u80de\u584a\u7d30\u80de\u5185\u306e\u8ee2\u5199\u52d5\u614b\u3092\u6642\u7a7a\u9593\u7684\u306b\u89e3\u6790\u3057\u3001\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u30fb\u539f\u59cb\u5185\u80da\u8449\u3078\u306e\u5206\u5316\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3051\u308b\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u5f79\u5272\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u304c\u3001\u672c\u7814\u7a76\u306e\u80cc\u666f\u306b\u3042\u308b\u672a\u89e3\u660e\u306e\u8ab2\u984c\u3067\u3059\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u306e\u76ee\u7684<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5185\u90e8\u7d30\u80de\u584a\u306b\u304a\u3051\u308b\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u91cf\u591a\u69d8\u6027\u306e\u95a2\u4fc2<\/strong>\u3092\u5358\u4e00\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u660e\u3089\u304b\u306b\u3059\u308b\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u5185\u90e8\u7d30\u80de\u584a\u5185\u90e8\u306e\u5404\u7d30\u80de\u3067\u767a\u73fe\u3059\u308b\u91cd\u8981\u907a\u4f1d\u5b50\uff08\u4f8b\uff1a<em>Nanog<\/em>\u3084<em>Gata6<\/em>\u306a\u3069\uff09\u306e\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u6319\u52d5\u3092\u5b9a\u91cf\u5316\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u7d30\u80de\u9593\u306e\u767a\u73fe\u91cf\u3070\u3089\u3064\u304d\u3068\u306e\u5bfe\u5fdc\u95a2\u4fc2\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u307e\u3059\u3002<\/li>\n\n\n\n<li><strong>\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u304c\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u30fb\u539f\u59cb\u5185\u80da\u8449\u3078\u306e\u5206\u5316\u306b\u4e0e\u3048\u308b\u5f71\u97ff<\/strong>\u3092\u89e3\u660e\u3059\u308b\u3002\u3059\u306a\u308f\u3061\u3001\u5185\u90e8\u7d30\u80de\u584a\u7d30\u80de\u304c\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u3042\u308b\u3044\u306f\u539f\u59cb\u5185\u80da\u8449\u3078\u904b\u547d\u6c7a\u5b9a\u3059\u308b\u969b\u306b\u3001\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u983b\u5ea6\u3084\u5f37\u5ea6\u304c\u3069\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u306e\u304b\u3092\u691c\u8a3c\u3057\u3001\u7d30\u80de\u904b\u547d\u6c7a\u5b9a\u306e\u78ba\u7387\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3059\u3002<\/li>\n<\/ul>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"932\" height=\"904\" src=\"https:\/\/www.bioreg.kyushu-u.ac.jp\/labo\/ged\/wp\/wp-content\/uploads\/2025\/03\/TB-cellfate-purpose.png\" alt=\"\" class=\"wp-image-1306\" style=\"width:573px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u7814\u7a76\u624b\u6cd5<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>DNA\/RNA\/IF-seqFISH<\/strong><\/h3>\n\n\n\n<p>\u3000DNA-FISH\u3001RNA-FISH\u3001\u514d\u75ab\u67d3\u8272\uff08IF\uff09\u3092\u7d44\u307f\u5408\u308f\u305b\u305f<strong>\u9010\u6b21\u7684\u591a\u91cdFISH\u6cd5\uff08seqFISH\uff09<\/strong>\u3092\u80da\u7d44\u7e54\u306b\u9069\u7528\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u5185\u90e8\u7d30\u80de\u584a\u5185\u306e\u500b\u3005\u306e\u7d30\u80de\u306b\u304a\u3051\u308b\u8907\u6570\u907a\u4f1d\u5b50\u306emRNA\u767a\u73fe\u91cf\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u767a\u73fe\uff08\u8ee2\u5199\u56e0\u5b50\u306e\u5b58\u5728\u91cf\uff09\u3092\u540c\u6642\u306b\u53ef\u8996\u5316\u30fb\u5b9a\u91cf\u3057\u307e\u3059\u3002\u4f8b\u3048\u3070NANOG\u3084GATA6\u3092\u542b\u3080\u767a\u751f\u904b\u547d\u6c7a\u5b9a\u95a2\u9023\u56e0\u5b50\u306e\u767a\u73fe\u5206\u5e03\u3092\u4e00\u80da\u30ec\u30d9\u30eb\u3067\u30de\u30c3\u30d4\u30f3\u30b0\u3057\u3001\u7d30\u80de\u9593\u306e\u767a\u73fe\u591a\u69d8\u6027\u3092\u9ad8\u89e3\u50cf\u5ea6\u3067\u6e2c\u5b9a\u3057\u307e\u3059\u3002DNA-seqFISH\u306b\u3088\u308a\u5404\u907a\u4f1d\u5b50\u5ea7\u4f4d\u3067\u306e\u30a2\u30ea\u30eb\u3054\u3068\u306e\u8ee2\u5199\u72b6\u614b\u3082\u6349\u3048\u308b\u3053\u3068\u3067\u30011\u7d30\u80de\u5185\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u5225\u306e\u767a\u73fe\uff08\u30a2\u30ea\u30eb\u767a\u73fe\u504f\u308a\uff09\u307e\u3067\u89e3\u6790\u3057\u3001\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u7a7a\u9593\u5206\u5e03\u3084\u767a\u73fe\u3086\u3089\u304e\u30d1\u30bf\u30fc\u30f3\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3059\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"1670\" height=\"804\" src=\"https:\/\/www.bioreg.kyushu-u.ac.jp\/labo\/ged\/wp\/wp-content\/uploads\/2025\/03\/image-3.png\" alt=\"DNA\/RNA\/IF-seqFISH\u306e\u6a21\u5f0f\u56f3\u3002\" class=\"wp-image-1297\" style=\"width:675px;height:auto\"\/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-center has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-6ed9e9e4a362a1d6ad0f426bdab37137\">DNA\/RNA\/IF-seqFISH\u306e\u6a21\u5f0f\u56f3\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"youtube\"><iframe title=\"seqFISH\" src=\"https:\/\/www.youtube.com\/embed\/PbJDknSxyBo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-d622f8b81a5d23044f60ce68314f5684\">seq-DNA\/RNA\/IF-FISH\u306e\u4ee3\u8868\u7684\u306a\u753b\u50cf\u3002\u672c\u52d5\u753b\u306f\u3001seq-DNA\/RNA-IF-FISH\u3092\u7528\u3044\u3066\u5404\u30e9\u30a6\u30f3\u30c9\u3067\u53d6\u5f97\u3055\u308c\u305f\u753b\u50cf\u306e\u6700\u5927\u8f1d\u5ea6\u6295\u5f71\u304b\u3089\u4f5c\u6210\u3055\u308c\u3066\u3044\u308b\u3002\u5404\u30e9\u30a6\u30f3\u30c9\u306b\u304a\u3044\u3066\u30013\u7a2e\u985e\u306e\u4e8c\u6b21\u30d7\u30ed\u30fc\u30d6\u30bb\u30c3\u30c8\u304a\u3088\u3073\u8aad\u307f\u53d6\u308a\u30d7\u30ed\u30fc\u30d6\u30bb\u30c3\u30c8\u304c\u4f7f\u7528\u3055\u308c\u30013\u3064\u306e\u30c1\u30e3\u30f3\u30cd\u30eb\u3092\u4ecb\u3057\u305f\u753b\u50cf\u53d6\u5f97\u304c\u53ef\u80fd\u3067\u3042\u3063\u305f\u3002\u305d\u308c\u305e\u308c\u306e\u30c1\u30e3\u30f3\u30cd\u30eb\u306f\u5358\u4e00\u306eRNA\u3001\u30b2\u30ce\u30e0\u9818\u57df\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u307e\u305f\u306f\u7ffb\u8a33\u5f8c\u4fee\u98fe\u306e\u5c40\u5728\u3092\u89b3\u5bdf\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u305f\u3002(Ohishi et al., <strong><em>Sci Adv<\/em><\/strong>, 2020)<br><br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>\u751f\u7d30\u80de\u5358\u4e00\u907a\u4f1d\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853<\/strong><\/h3>\n\n\n\n<p>\u3000\u30e9\u30a4\u30d6\u30bb\u30eb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3088\u308a\u3001\u521d\u671f\u80da\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u306b\u304a\u3051\u308b\u5185\u90e8\u7d30\u80de\u584a\u69d8\u7d30\u80de\u5185\u306e\u7279\u5b9a\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u52d5\u614b\u3092\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306b\u89b3\u5bdf\u3057\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u5358\u4e00\u907a\u4f1d\u5b50\u53ef\u8996\u5316\u30b7\u30b9\u30c6\u30e0 (STREAMING-tag\u30b7\u30b9\u30c6\u30e0; <a href=\"https:\/\/www.nature.com\/articles\/s41467-022-35286-2\" target=\"_blank\" rel=\"noreferrer noopener\">Ohishi et al., <strong>Nat Commun<\/strong>, 2022<\/a>) \u3092\u7528\u3044\u3066<em>Nanog<\/em>\u7b49\u306e\u6a19\u7684\u907a\u4f1d\u5b50\u306e\u7d30\u80de\u6838\u5185\u5c40\u5728\u3001mRNA\u5408\u6210\u30a4\u30d9\u30f3\u30c8\u3092\u53ef\u8996\u5316\u3057\u3001\u5185\u90e8\u7d30\u80de\u584a\u69d8\u7d30\u80de\u3067\u306e\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u304c\u767a\u751f\u3059\u308b\u69d8\u5b50\u3092\u8a18\u9332\u3057\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u8ee2\u5199\u30d0\u30fc\u30b9\u30c8\u306e\u983b\u5ea6\uff08ON\u72b6\u614b\u306b\u306a\u308b\u983b\u5ea6\uff09\u3084\u30b5\u30a4\u30ba\uff08ON\u4e00\u56de\u3042\u305f\u308a\u7523\u751f\u3055\u308c\u308bRNA\u6570\uff09\u3092\u6642\u9593\u5206\u89e3\u80fd\u9ad8\u304f\u6e2c\u5b9a\u3057\u3001\u500b\u3005\u306e\u7d30\u80de\u304c\u3082\u3064\u8ee2\u5199\u52d5\u614b\u306e\u7279\u5fb4\u3092\u62bd\u51fa\u3057\u3064\u3064\u3001\u7d30\u80de\u904b\u547d\u6c7a\u5b9a\u3068\u306e\u95a2\u4fc2\u6027\u3092\u89e3\u304d\u660e\u304b\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<figure class=\"wp-block-embed aligncenter is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"youtube\"><iframe title=\"STREAMING-tag system\" src=\"https:\/\/www.youtube.com\/embed\/MrUqTxu-VRY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/div>\n<\/div><\/figure>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-small-font-size wp-elements-1a4f6551b759baa85b78beba15b9af61\"><strong>\u5358\u4e00\u907a\u4f1d\u5b50\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u6280\u8853(STREAMING-tag\u30b7\u30b9\u30c6\u30e0)\u306e\u6a21\u5f0f\u56f3\u3068\u672c\u6280\u8853\u3092\u5229\u7528\u3057\u3066\u64ae\u5f71\u3055\u308c\u305f\u52d5\u753b\u3002<\/strong>\u30de\u30a6\u30b9ES\u7d30\u80de\u306e<em>Nanog<\/em>\u907a\u4f1d\u5b50\u306bSTREAMING-tag\u304c\u9069\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u672c\u7d30\u80de\u309215\u79d2\u9593\u9694\u3067\u64ae\u5f71\u3057\u305f\u52d5\u753b\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-embed aligncenter is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<div class=\"youtube\"><iframe title=\"STREAMING-tag system (long time-lapse)\" src=\"https:\/\/www.youtube.com\/embed\/cIPwzd5pGMw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; 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