The 26th Hot Spring Harbor International Symposium

−Trans-Omics: New Approaches in Biology and Medicine−

Medical Institute of Bioregulation, Kyushu University


November 2-3, 2016

Collaborative Research Station Hall I, Hospital Campus, Kyushu University, Fukuoka, JAPAN



Wednesday, November 2, 2016


Opening Remarks: Yusaku Nakabeppu (Director of Medical Institute of Bioregulation)



Session 1:

Signaling Networks                      Chair: Takeshi Bamba


S-01: Mariko Okada (Osaka University, Japan)


Multiple-scale cooperativity in signal-transcription network for cellular commitment 




S-02: Hiroyuki Kubota (Kyushu University, Japan)


Trans-omic analysis of insulin action-toward in vivo trans-omic analysis-




S-03: Uwe Sauer (ETH Zurich, Switzerland)


Coordination of metabolism through metabolite-protein interactions




Group Photos


Lunch (Transomics meeting by invitation only)



Session 2:

Transcription, Translation and Robustness  Chair: Mikita Suyama


S-04: Hisao Moriya (Okayama University, Japan)


Consequences of protein overexpression



S-05: Yasuyuki Ohkawa (Kyushu University, Japan)


The baseline of transcription level is determined by selective incorporation of histone H3 variants




S-06: Timothy J. Stasevich (Colorado State University, USA)


Real-time imaging of single mRNA translation dynamics in living cells




Coffee break



Session 3:

Short Talks by Young Scientists           Chair: Tohru Ishitani


Short talks of 12 minutes each (see p.4 for details)




Coffee break



Session 4:

Development and Differentiation          Chair: Atsushi Suzuki


S-07: Hiroyuki Sasaki (Kyushu University, Japan)


Multiple functions of the epigenetic regulator UHRF1 in mouse oocytes revealed by trans-omics approaches




S-08: Akira Nakamura (Kumamoto University, Japan)


Search for new factors that direct germ cell formation in the Drosophila embryo




S-9: Naoki Irie (University of Tokyo, Japan)


Why are vertebratesf organogenesis stages evolutionarily conservative?




Dinner party (by invitation only)










Thursday, November 3, 2016

Session 5:

Disease_I                              Chair: Hiroki Shibata


S-10: Tatsuhiko Tsunoda (Tokyo Medical and Dental University, Japan)


Trans-omic analysis strategy for precision medicine




S-11: Yoshiyuki Minegishi (Tokushima University, Japan)


Identification of the molecular pathogenesis of hyper-IgE syndrome




S-12: Yong Hou (Beijing Genomics Institute, China)


Efforts to push single cell trans-omics for cancer research







Session 6:

Disease_I I                             Chair: Yoshihiro Yamanishi


S-13: Keiichi Nakayama (Kyushu University, Japan)


Next-generation proteomics unveils a global landscape of
cancer metabolism




S-14: Jun Koseki (Osaka University, Japan)


Trans-omics analysis shows novel functional change in the ornithine metabolic pathway between cancer stem cells and non-cancer stem cells




S-15: Marie Evangelista (Genentech, USA)


Lessons from targeting metabolic dependencies in PDAC




Closing Remarks: Hiroyuki Sasaki (Kyushu University, Japan)





Session3: Short-Talk Session for Young Scientists   Chair: Tohru Ishitani

Wednesday, November, 2 2016


14:45-16:45  Short talks of 12 minutes each


Y-01: Shinjiro Hino (Kumamoto University, Japan)

Regulation of cellular metabolism by histone demethylase LSD1


Y-02: Kou Motani (Tokushima University, Japan)

Identification of STING-dependent secreted proteins using quantitative proteomic analysis


Y-03: Kenji Shimazu (Tokushima University, Japan)

Characterization of target genes for inhibitory co-receptor PD-1 by CAGE


Y-04: Yuki Kawasaki (Tokyo Medical and Dental University, Japan)

Development of the novel method gEnIGMAh for simultaneous identification of methylcytosine and hydroxymethylcytosine


Y-05: Yuki Akieda (Kyushu University, Japan)

Apoptosis-mediated elimination of "Wnt/ƒΐ-catenin signaling noise" supports precise embryonic patterning


Y-06: Yuta Katayama (Kyushu University, Japan)

CHD8 haploinsufficiency results in autistic-like phenotypes in mice


Y-07: Ryusuke Sawada (Kyushu University, Japan)

Transomics-based drug repositioning for a wide range of diseases


Y-08: Kai Inui (Kyushu University, Japan)

Analysis of nonsense-mediated mRNA decay (NMD) using genomic and transcriptomic data


Y-09: Yuuta Imoto (Kyushu University, Japan)

Post-genomic analysis of supramolecular nanomachinery for membrane-bounded organelle division


Y-10: Yuki Sohma (Kyushu University, Japan)

Metabolomics on designed metabolic dynamics by synthetic genetic circuits