Hornigold K, Baker M, Machin P, Chetwynd S, Johnsson A, Pantarelli C, Islam
P, Stammers M, Crossland L, Oxley D, Okkenhaug H, Walker S, Walker R, Segonds-Pichon
A, Fukui Y, Malliri A, Welch H
The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses.
Front. Immunol. 14:1223653, 2023 (IF=8.8)
Hata K, Yanagihara T, Matsubara K, Kunimura K, Eto D, Suzuki K, Tsubouchi K, Ikegame S, Fukui Y, Okamoto I
Altered macrophage phenotypes in a case of autoimmune pulmonary alveolar
proteinosis.
ERJ Open Res. 9:00500, 2023 (IF=4.2)
Yanagihara T, Hata K, Matsubara K, Kunimura K, Suzuki K, Tsubouchi K, Ikegame
S, Baba Y, Fukui Y, Okamoto I
Mass cytometry analysis of B-cell populations in extranodal marginal-zone
lymphoma of mucosa-associated lymphoid tissue of the lung.
Ann Hematol.102(10):2959-2961, 2023 (IF=3.5)
Ueda Y, Higasa K, Kamioka Y, Kondo N, Horitani S, Ikeda Y, Bergmeier W,
Fukui Y, Kinashi T
Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1.
iScience 26(8):107292, 2023 (IF=6.1)
Exploratory mass cytometry analysis reveals immunophenotypes of cancer
treatment-related pneumonitis..
eLife 2023
Machin P, Johnsson A, Massey E, Pantarelli C, Chetwynd S, Chu J, Okkenhaug
H, Segonds-Pichon A, Walker S, Malliri A, Fukui Y, Welch H
Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.
Front. Immunol. 14:1180886, 2023 (IF=8.8)
Kunimura K, Akiyoshi S, Uruno T, Matsubara K, Sakata D, Morino K, Hirotani
K, Fukui Y
DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis.
J. Allergy Clin. Immunol. 151: 1585-1594, 2023. (IF=14.3)
Yanagihara T, Hata K, Suzuki K, Matsubara K, Kunimura K, Tsubouchi K ,
Eto D, Ando H, Uehara M, Ikegame S, Fukui Y, Okamoto I
Expansion of ST2-expressing macrophages in a patient with bronchiolitis
obliterans syndrome.
ERJ Open Res. 9:00033, 2023 (IF=4.2)
Hata K, Yanagihara T, Matsubara K, Kunimura K, Suzuki K, Tsubouchi K ,
Eto D, Ando H, Uehara M, Ikegame S, Baba Y, Fukui Y, Okamoto I
Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar
lavage fluid from interstitial lung diseases.
Front. Immunol. 14:1145814, 2023 (IF=8.8)
Kukimoto-Niino M, Ihara K, Mishima-Tsumagari C, Inoue M, Fukui Y, Yokoyama S, Sirouzu M
Structural basis for the dual GTPase specificity of the DOCK10 guanine
nucleotide exchange factor.
Biochem. Biophys. Res. Commun. 653:12-20, 2023 (IF=3.3)
Morino K, Kunimura K, Sugiura Y, Izumi Y, Matsubara K, Akiyoshi S, Maeda
Cholesterol sulfate limits neutrophil recruitment and gut inflammation
during mucosal injury.
Front. Immunol. 14:1131146, 2023 (IF=8.8)
Namkoong H, (他473名) Fukui Y, (他14名) Okada Y
DOCK2 is involved in the host genetics and biology of severe COVID-19.
Nature 609:754-760, 2022 (IF=69.5)
Kunimura K, Yamamura K, Nakahara T, Kido-Nakahara M, Uruno T, Fukui Y
Identification of a functional DOCK8 gene polymorphism associated with
atopic dermatitis.
Allergy 77:3670-3672, 2022 (IF=14.7)
Tatsuguchi T, Uruno T, Sugiura Y, Oisaki K, Takaya D, Sakata D, Izumi Y, Togo H, Hattori Y, Kunimura K, Sakurai T, Honma T, Bamba T, Nakamura M, Kanai M, Suematsu M, Fukui Y
Pharmacological intervention of cholesterol sulfate-mediated T Cell exclusion
promotes.
Biochem. Biophys. Res. Commun. 609:183-188, 2022 (IF=3.3)
Tatsuguchi T, Uruno T, Sugiura Y, Sakata D, Izumi Y, Sakurai T, Hattori
Y, Oki E, Kubota N, Nishimoto K, Oyama M,
Kunimura K, Ohki T, Bamba T, Tahara H, Sakamoto M, Nakamura M, Suematsu
M, Fukui Y
Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration
by effector T cells..
Int. Immunol., 34:277-289, 2022 (IF=5.0)
Kamikaseda Y, Uruno T, Kunimura K, Harada A, Saiki K, Oisaki K, Sakata D, Nakahara T, Kido-Nakahara M, Kanai M, Nakamura S, Ohkawa Y, Furue M, Fukui Y
Target inhibition of EPAS1-driven IL-31 production by a small-molecule
compound.
J. Allergy Clin. Immunol. 148:633-638, 2021 (IF=14.3)
Matsubara K, Kunimura K, Yamane N, Aihara R, Sakurai T, Sakata D, Uruno
T, Fukui Y
DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion
of group 2 innate lymphoid cells.
Biochem. Biophys. Res. Commun. 559:135-140, 2021 (IF=3.3)
Koga T, Sasaki F, Saeki K, Tsuchiya S, Okuno T, Ohba M, Ichiki T, Iwamoto
S, Uzawa H, Kitajima K, Meno C, Nakamura F, Tada N, Fukui Y, Kikuta J, Ishii M, Sugimoto Y, Nakao M, Yokomizo T
Expression of leukotriene B4 receptor 1 difines functionally distinct DCs
that control allergic skin inflammation.
Cell. Mol. Immunol. 18:1437-1449, 2020 (IF=8.4)
Sakurai T, Kukimoto-Niino M, Kunimura K, Yamane N, Sakata D, Aihara R,
Yasuda T, Yokoyama S, Shirouzu M, Fukui Y, Uruno T
A conserved PI (4,5) P2-binding domain is critical for immune regulatory
function of DOCK8.
Life Sci. Alliance 4:e202000873, 2021 (IF=5.8)
Aihara R, Kunimura K, Watanabe M, Uruno T, Yamane N, Sakurai T, Sakata
D, Nishimura F, Fukui Y
DOCK8 controls survival of group 3 innate lymphoid cells in the gut through
Cdc42 activation.
Int. Immunol. 33:149-160, 2021 (IF=5.0)
Okumura F, Fujiki Y, Oki N, Fukui Y, Nakatsukasa K, Kamura T
Cul5-type ubiquitin ligase KLHDC1 contributes to the elimination of truncated
SELENOS produced by failed UGA/Sec decoding.
iScience 23:100970, 2020 (IF=6.1)
Kunimura K, Sakata D, Tun X, Uruno T, Ushijima M, Katakai T, Shiraishi
A, Aihara R, Kamikaseda Y, Matsubara K, Kanegane H, Sawa S, Eberl G, Ohga
S, Yoshikai Y, Fukui Y
S100A4 protein is essential for the development of mature microfold cells
in Peyer's patches.
Cell Rep. 29:2823-2834, 2019 (IF=10.0)
Sakata D, Uruno T, Matsubara K, Andoh T, Yamamura K, Magoshi Y, Kunimura
K, Kamikaseda Y, Furue M, Fukui Y
Selective role of neurokinin B in IL-31-induced itch response in mice.
J.Allergy Clin. Immunol. 144:1130-1133, 2019 (IF=14.3)
Gotoh K, Morisaki T, Setoyama D, Sasaki K, Yagi M, Igami K, Mizuguchi S,
Uchiumi T, Fukui Y, Kang D
Mitochondrial p32/C1 qbp is a critical regulator of dendritic cell metabolism
and maturation.
Cell Rep. 25:1800-1815, 2018 (IF=10.0)
Sakurai T, Uruno T, Sugiura Y, Tatsuguchi T, Yamamura K, Ushijima M, Hattori
Y, Kukimoto-Niino M, Mishima-Tsumagari C, Watanabe M, Suematsu M, Fukui Y
Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific
immune evasion in the eye.
Science Signaling 11:1-11, 2018 (IF=9.5)
Tomino T, Tajiri H, Tatsuguchi T, Shirai T, Oisaki K, Matsunaga S, Sanematsu F, Sakata D, Yoshizumi T, Maehara Y, Kanai M, Cote JF, Fukui Y, Uruno T
DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced
by self-activating Rac1P29S mutation.
Biochem. Biophys. Res. Commun. 497:298-304, 2018 (IF=3.5)
Ushijima M, Uruno T, Nishikimi A, Sanematsu F, Kamikaseda K, Kunimura K,
Sakata D, Okada T, Fukui Y
The rac activator DOCK2 mediates plasma cell differentiation and IgG antibody
production.
Front Immunol. 9:243, 2018 (IF=7.5)
Yamazaki S, Tanaka Y, Araki H, Kohda A, Sanematsu F, Arasaki T, Duan X,
Miura F, Katagiri T, Shindo R, NakanoH, Ito T, Fukui Y, Endo S, Sumimoto H
The AP-1 transcription factor JunB is required for Th17 cell diferentiation.
Sci. Rep. 7:17402, 2017 (IF=4.3)
Okumura F, Joo-Okumura A, Obara K, Petersen A, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T
Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by
EphB2.
Mol. Biol. Cell. 28:3532-3541, 2017 (IF=3.7)
Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, Losic B, Shah H, Lee E, Wang M, Faith JJ, Kasarskis A, Brodmerkel C, Curran M, Das A, Friedman JR, Fukui Y, Humphrey MB, Iritani BM, Sibinga N, Tarrant TK, Argmann C, Hao K, Roussos
P, Zhu J, Zhang B, Dobrin R, Mayer LF, Schadt EE
A functional genomics predictive network model identifies regulators of
inflammatory bowel disease.
Nature Genetics 49:1437-1449, 2017 (IF=28.0)
Ackerknecht M, Gollmer K, Germann P, Ficht X, Abe J, Fukui Y, Swoger J, Ripoll J, Sharpe J, Sharpe J, Stein JV
Antigen availability and DOCK2-driven motility govern CD4+ T cell interactions
with dendritic cells in vivo.
J. Immunol. 199:520-530, 2017(IF=4.9)
Yanagihara T, Tomino T, Uruno T, Fukui Y
Thymic epithelial cell-specific deletion of Jmjd6 reduces Aire protein
expression and exacerbates disease development in a mouse model of autoimmune
diabetes.
Biochem. Biophys. Res. Commun. 491:1126, 2017(IF=2.5)
Tajiri H, Uruno T, Shirai T, Takaya D, Matsunaga S, Setoyama D, Watanabe
M, Kukimoto-Niino M, Oisaki K, Ushijima M, Sanematsu F, Honma T, Terada
T, Oki E, Shirasawa S, Maehara Y, Kang D, Cote JF, Yokoyama S, Kanai M,
Fukui Y
Targeting Ras-Driven cancer cell survival and invasion through selective
inhibition of DOCK1.
Cell Rep. 19:969-980, 2017(IF=8.3)
Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe
M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation
via IL-31 induction.
Nature Commun. 8:13946, 2017 (IF=11.3)
Shiraishi A, Uruno T, Sanematsu F, Ushijima M, Sakata D, Hara T, Fukui Y
DOCK8 regulates macrophage migration through Cdc42 activation and LRAP35a
interaction.
J. Biol. Chem. 292:2191-2202, 2017 (IF=4.3)
Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi
A, Fukui Y, Nakatsukasa K, Kamura T
ASB7 regulates spindle dynamics and genome integrity by targeting DDA3
for proteasomal degradation.
J. Cell. Biol. 215:95-106, 2016 (IF=8.7)
Liu Z, Man SM, Zhu Q, Vogel P, Frase S, Fukui Y, Kanneganti TD
DOCK2 confers immunity and intestinal colonization resistance to Citrobacter
rodentium infection.
Sci. Rep. 6:27814, 2016 (IF=5.2)
Okumura F, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin
T, Fukui Y, Nakatsukasa K, Kamura T
Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation
of B-Myb and Hypoxia-Inducible Factor α
Mol. Cell. Biol. 36:1803-1817, 2016 (IF=4.4)
Yanagihara T, Sanematsu F, Sato T, Uruno T, Duan X, Tomino T, Harada Y,
Watanabe M, Wang Y, Tanaka Y, Nakanishi Y, Suyama M, Fukui Y
Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction
in the thymus.
Nature Commun. 6:8820, 2015 (IF=11.5)
Guo X, Shi N, Cui X-B, Wang J-N, Fukui Y, Chen S-Y
Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic
modulation and vascular remodeling.
Cir. Res. 116:e71-80, 2015 (IF=11.8)
Moalli F, Cupovic J, Thelen F, Halbherr P, Fukui Y, Narumiya S, Ludewig B, Stein JV
Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell-dendritic cell interactions.
J. Exp. Med. 211:2507-2517, 2014 (IF=13.2)
Sreeramkumar V, Adrover JM, Ballesteros I, Cuartero MI, Rossaint J, Bilbao
I, Nacher M, Pitaval C, Radovanovic I, Fukui Y, McEver RP, Filippi M-D, Lizasoain I, Ruiz-Cabello J, Zarbock A, Moro
MA, Hidalgo A
Neutrophils scan for activated platelets to initiate inflammation.
Science 346:1234-1238, 2014 (IF=31.5)
Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Cote JF, Sumimoto H, Fukui Y
DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide
production, and extracellular trap formation.
J. Immunol. 193:5660-5667, 2014 (IF=5.3)
Abu-Thuraia A, Gauthier R, Chidiac R, Fukui Y, Screaton RA, Gratton JP, Cote JF
Axl phosphorylates Elmo scraffold proteins to promote Rac activation and
cell invasion.
Mol. Cell. Biol. 35:76-87, 2015 (IF=5.0)
Wen Y, Elliott MJ, Huang Y, Miller TO, Corbin DR, Hussain L-R, Ratajczak
MZ, Fukui Y, Ildstad ST
DOCK2 is critical for CD8＋TCR－ graft facilitating cells to enhance engraftment of hematopoietic stem
and progenitor cells.
Stem Cells 32:2732-2743, 2014 (IF=7.1)
Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, Sanematsu F, Yamamura K,
Terasawa M, Nishikimi A,
Cote JF, Fukui Y
DOCK5 functions as a key signaling adaptor that links FcεRI signals to
microtubule dynamics during mast cell degranulation.
J. Exp. Med. 211:1407-1419, 2014 (IF=13.2)
Damoulakis G, Gambardella L, Rossman K, Lawson C, Anderson K, Fukui Y, Welch H, Der CJ, Stephens L, Hawkins P
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signaling and
actin polarity in neutrophils.
J. Cell Sci. 127:2589-2600, 2014 (IF=5.9)
Laurin M, Dumouchel A, Fukui Y, Cote JF
The Rac-specific exchange factors Dock1 and Dock5 are dispensable for the
establishment of the glomerular filtration barrier in vivo.
Small GTPases 4:4, 2013 (IF=xx)
Floc'h AL, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M
Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at
the immunological synapse.
J. Exp. Med. 210:2721-2737, 2013 (IF=13.2)
Kamakura S, Nomura M, hayase J, Iwakiri Y, Nishikimi A, Takayanagi R, Fukui Y, Sumimoto H
The cell polarity protein mlnsc regulates neutrophil chemotaxis via a noncanonical
G protein signaling pathway.
Dev. Cell. 26:292-302, 2013 (IF=12.9)
Sakai Y, Tanaka Y, Yanagihara T, Watanabe M, Duan X, Terasawa M, Nishikimi
A, Sanematsu F, Fukui Y
The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity
in mice through the lytic synapse formation.
Blood 122:386-393, 2013 (IF=9.1)
Laurin M, Huber J, Pelletier A, Houalla T, Park M, Fukui Y, Haibe-Kains B, Muller WJ, Cote JF
Rac-specific guanine uncleotide exchange factor DOCK1 is a critical regulator
of HER2-mediated breast cancer metasis.
Proc. Natl. Acad. Sci. USA 110:7434-7439, 2013 (IF=9.7)
Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Cote
JF, Fukui Y
Phosphatidic acid-dependent recruitment and function of the Rat activator
DOCK1 during dorsal ruffle formation.
J. Biol. Chem. 288:8092-8100, 2013 (IF=4.8)
Cimino PJ, Yang Y, Li X, Hemingway JF, Cherne MK, Khademi SB, Fukui Y, Montine KS, Montine TJ, Keene CD
Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse
model of Alzheimer's disease.
Exp. Mol. Pathol. 94:366-371, 2013 (IF=2.4)
Unoki M, Masuda A, Dohmae N, Arita K, Yoshimatsu M, Iwai Y, Fukui Y, Ueda K, Hamamoto R, Shirakawa M, Sasaki H, Nakamura Y
Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain
containing 6 (JMJD6).
J. Biol. Chem. 288:6053-6062, 2013 (IF=4.8)
Fujimori S, Hirai N, Ohashi H, Masuoka K, Nishikimi A, Fukui Y, Washio T, Oshikubo T, Yamashita T, Miyamoto-Sato E
Next-generation sequencing coupled with a cell-free display technology
for high-throughput production of reliable interactome data.
Scientific Reports. 2:1-5, 2012 (IF=5.2)
Terasawa M, Uruno T, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y.
Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and
lymphocyte migration.
PLOS ONE 7(9):e46277, 2012 (IF=4.1)
Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration
during immune responses.
Blood 119:4451-4461, 2012 (IF=10.6)
Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sasaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y
Blockade of inflammatory responses by a small-molecule inhibitor of the
Rac activator DOCK2.
Chem. Biol. 19:488-497, 2012 (IF=5.8)
Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa
N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M,
Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S
Structual basis for mutual relief of the Rac guanine nucleotide exchange
factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Proc. Natl. Acad. Sci. USA 109:3305-3310, 2012 (IF=9.8)
Ippagunta SK, Subbarao Malireddi RK, Shaw PJ, Neale GA, Walle LV, Green
DR, Fukui Y, Lamkanfi M, Kanneganti T-D
The inflammasome adaptor ASC regulates the function of adaptive immune
cells by controlling Dock2-mediated Rac activation and actin polymerization.
Nature Immunol. 12:1010-1018, 2011 (IF=25.7)
Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding
G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Cote JF, Nagasawa
T, Fukui Y
DOCK180 is a rac activator that regulates cardiovascular development by
acting downstream of CXCR4.
Circ. Res. 107:1102-1105, 2010 (IF=9.2)
Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AC, Martin AM, Soriano SF,
Natale D, Henrickson SE, Andrian UH,
Fukui Y, Mellado M, Deutsch U, Engelhardt B, Stein JV
Comprehensive analysis of lymph node stroma-expressed Ig superfamily members
reveals redundant and
non-redundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing..
Blood 116:915-925, 2010 (IF=10.6)
Kumar V, Scandella E, Danuser R, Onder L, Nitschke M, Fukui Y, Halin C, Ludewig B, Stein JV
Global lymphoid tissue remodeling during a viral infection is orchestrated
by a B cell-lymphotoxin-dependent pathway.
Blood 115:4725-4733, 2010 (IF=10.6)
Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Maeda N, Ishikawa
T, Hoshino K, Uruno T, Cao Q,
Higashi S, Kawaguchi Y, Enjoji M, Takayanagi R, Kaisho T, Yoshikai Y, Fukui Y
Selective control of type I IFN induction by the Rac activator DOCK2 during
TLR-mediated plasmacytoid
dendritic cell activation.
J. Exp. Med. 207:721-730, 2010 (IF=15.5)
Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira A, Mimuro H, Sasakawa C, Fukui Y, Fujihashi K, Akiyama T, Inoue J, Enninger JM, Kunisawa J, Kiyono H
Id2-RORγt-, and LTβR-independent lymphoid organogenesis in ocular immunity.
J. Exp. Med. 206:2351-2364, 2009 (IF=15.5)
Lei Y, Liu C, Saito F, Fukui Y, Takahama Y
Role of DOCK2 and DOCK180 in fetal thymus colonization.
Eur. J. Immunol. 39:2695-2702, 2009 (IF=4.9)
Cimino PJ, Sokal I, Leverenz J, Fukui Y, Montine TJ
DOCK2 is microglial specific regulator of CNS innate immunity found in
normal and Alzheimer's disease brain.
Am. J. Pathol. 175:1622-1630, 2009 (IF=5.7)
Gollmer K, Asperti-Boursin F, Tanaka Y, Okkenhaug K, Vanhaesebroeck B, Peterson JR, Fukui Y, Donnadieu E, Stein JV
CCL21 mediated CD4+ T cell costimulation via DOCK2/Rac-dependent pathway.
Blood 114:580-588, 2009 (IF=10.9)
Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu
F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman
MA, Fukui Y
Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil
chemotaxis.
Science 324:384-387, 2009 (IF=28.1)
Nakasaki T, Tanaka T, Okudaira S, Hirosawa M, Umemoto E, Otani K, Jin
S, Bai Z, Hayasaka H, Fukui Y, Aozasa K, Fujita N, Tsuruo T, Ozono K, Aoki J, Miyasaka M
Involvement of the lysophosphatidic acid-generating enzyme autotaxin in
lymphocyte-endothelial cell interactions.
Am. J. Pathol. 173:1566-1576, 2008 (IF=5.5)
Gotoh K, Tanaka Y, Nishikimi A, Inayoshi A, Enjoji M, Takayanagi R, Sasazuki
T, Fukui Y
Differential requirement for DOCK2 in migration of plasmacytoid dendritic
cells versus myeloid dendritic cells.
Blood 111:2973-2976, 2008 (IF=10.４)
Kikuchi T, Kubonisni S, Shibakura M, Namba T, Fukui Y, Tanimoto M, Katayama Y
Dock2 participates in bone marrow lympho-hematopoiesis.
Biochem. Biophys. Res. Commun. 367:90-96, 2008 (IF=2.9)
Tanaka Y, Hamano S, Gotoh K, Murata Y, Kunisaki Y, Nishikimi A, Takii R,
Kawaguchi M, Inayoshi A, Masuko S, Himeno K, Sasazuki T, Fukui Y
T helper type 2 differentiation and intracellular trafficking of the interleukin
4 receptor-α subunit controlled by the Rac activator Dock2.
Nature Immunol. 8:1067-1075, 2007 (IF=27.6)
Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E,
Martinez-A C, Fukui Y, von Andrian UH, Stein JV
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated
egress.
J. Exp. Med. 204:497-510, 2007 (IF=14.0)
Handa Y, Suzuki M, Ohya K, Iwai H, Ishijima N, Koleske AJ, Fukui Y, Sasakawa C
Shignella IpgB1 promotes bacterial entry through the ELMO-Dock 180 machinery.
Nature Cell Biol. 9:121-128, 2007 (IF=19.7)
Higuchi N, Kato M, Kotoh K, Kohjima M, Aishima S, Nakamuta M, Fukui Y, Takayanagi R, Enjoji M
Methylprednisolone injection via the portal vein suppresses inflammation
in acute liver failure induced in rats by lipopolysaccharide and d-galactosamine.
Liver Int. 27:1342-1348, 2007 (IF=2.3)
Garcia-Bernal D, Sotillo-Mallo E, Nombela-Arrieta C, Samaniego R, Fukui Y, Stein JV, Texidio J
DOCK2 is required for chemokine-promoted human T lymphocyte adhesion under
shear stress mediated by the integrin α4β1.
J. Immunol. 177:5215-5225, 2006 (IF=6.4)
Kunisaki Y, Nishikimi A, Tanaka Y, Takii R, Noda M, Inayoshi A, Watanabe
K, Sanematsu F, Sasazuki T, Sasaki T, Fukui Y
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil
chemotaxis.
J. Cell Biol. 174:647-652, 2006 (IF=11.0)
Shulman Z, Pasvolsky R, Woolf E, Grabovsky V, Feigelson SW, Erez N, Fukui Y, Alon R
DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not
transendothelial migration.
Blood 108:2150-2158, 2006 (IF=10.1)
Kunisaki Y, Tanaka Y, Sanui T, Inayoshi A, Noda M, Nakayama T, Harada M,
Taniguchi M, Sasazuki T, Fukui Y
DOCK2 is required in T cell precursors for development of Vα14 NK T cells
J. Immunol. 176:4640-4645, 2006 (IF=6.4)
Jiang H,Pan F, Erickson LM, Jang M-S, Sanui T, Kunisaki Y, Sasazuki T,
Kobayashi M, Fukui Y.
Deletion of Dock2,a regulator of the actin cytoskelton in lymphocytes,suppresses
cardiac allograft rejection.
J. Exp. Med. 202:1121-1130, 2005 (IF=14.6)
Nombela-Arrieta C, Lacalle RA, Montoya MC, Kunisaki Y, Megias D Marques
M, Carrera AC, Manes S, Fukui Y, Carlos Martinez-A, Stein, JV
Differential requirements for DOCK2 and phosphoinositide-3-Kinase γ during
T and B lymphocyte homing
Immunity 21:429-441, 2004 (IF=15.4)
Kunisaki Y, Masuko S, Noda M, Inayoshi A, Sanui T, Harada M, Sasazuki T,
Fukui Y
Defective fetal liver erythropoiesis and T-lymphopoiesis in mice lacking
phosphatidylserine receptor.
Blood 103:3362-3364, 2004 (IF=9.8)
Sanui T, Inayoshi A, Noda M, Iwata E, Oike M, Sasazuki T, Fukui Y
DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts,
but not PKC-θ and LFA-1, in T cells.
Immunity 19:119-129, 2003 (IF=15.4)
Sanui T, Inayoshi A, Noda M, Iwta E, Stein JV, Sasazuki T, Fukui Y
DOCK2 regurates Rac activation and cytoskeltal reorganization through
the interaction with ELMO1.
Blood 102:2948-2950, 2003 (IF=9.8)
Fukui Y, Hashimoto O, Sanui T, Koga H, Abe M,Inayoshi A, Noda M, Oike M, Shirai T, Sasazuki T
Haematopoietic cell-specific CDM family protein DOCK2 is essential for
lymphocyte migration.
Nature 412:826-831, 2001 (IF=32.2)
Oono T, Fukui Y, Masuko S, Hashimoto O, Sanui T, Inayoshi A, Noda M, Sata M, Sasazuki
T
Organ-specific autoimmunity in mice whose T cell repertoire is shaped by
a single antigenic peptide.
J. Clin. Invest. 108: 1589-1596, 2001 (IF=14.2)
Fukui Y, Oono T, Cabaniols JP, Nakao K, Hirokawa K, Inayoshi A, Sanui T, Kanellopoulos
J, Iwata E, Noda M, Katsuki M, Kourilsky P, Sasazuki T
Diversity of T cell repertoire shaped by a single peptide ligand is critically
affected by its amino acid residue at a T cell receptor-contact.
Proc. Natl. Acad. Sci. USA. 97:13760-13765, 2000 (IF=10.5)
Kawamura K, Yamamura T, Yokoyama K, Chui DH, Fukui Y, Sasazuki T, Inoko H, David CD, Tabira T
HLA-DR2-restricted responses to proteolipid protein 95-116 peptide cause
autoimmune encephalitis in transgenic mice.
J. Clin. Invest. 105:977-984, 2000 (IF=14.2)
Sano T, Yamamoto K, Fukui Y, Sasazuki T
Spontaneous clustering of Thy-1 antigens on CD4+CD8+ thymocytes lacking TCR engagement by MHC/peptide complexes.
Eur. J. Immunol. 29:403-412, 1999 (IF=5.0)
Nishimura H, Washizu J, Naiki Y, Hara T, Fukui Y, Sasazuki T, Yoshikai Y
MHC class -dependent NK1.1+γδ T cells are induced in mice by Salmonella infection.
J. Immunol. 162:1573-1581, 1999 (IF=6.5)
Matsuki N, Ogasawara K, Takami K, Namba K, Takahashi A, Fukui Y, Sasazuki T, Iwabuchi K, Good RA, Onoe K
Prevention of Infection of influenza virus in DQ6 mice, a human model by
a peptide vaccine prepared according to the cassette theory.
Vaccine 17:1161-1168, 1999 (IF=2.8)
Fukui Y, Hashimoto O, Inayoshi A, Gyotoku T, Sano T, Koga T, Gushima T, Sasazuki
T
Highly restricted T cell repertore shaped by a single major histocompatibility
complex-peptide ligand in the presense of a single rearranged T cell receptor
β chain.
J. Exp. Med. 188:897-907, 1998 (IF=14.6)
Gapin L, Fukui Y, Kanellopoulos J, Sano T, Casrouge A, Mailer V, Beaudoing E, GautheretD,
Claverie JM, Sasazuki T, Kourilsky P
Quantiative analysis of the T-cell repertoire by a single peptide/MHC complex..
J. Exp. Med. 187:1871-1883, 1998 (IF=14.6)
Gyotoku T, Fukui Y, Sasazuki T
An endogenously processed self peptide and the corresponding exogenous
peptide bound to the same MHC class II molecule could be distinct ligands
for TCR with different kinetic stability.
Eur. J. Immunol. 28:4050-4061, 1998 (IF=5.0)
Takahashi A, Ogasawara K, Matsuki N, Fujinaga K, Nakaya T, Ikuta K, Auwanit
W, Honda M, Fukui Y, Sasazuki T, Iwabuchi K, Onoe K.
Development of peptide vaccines inducing production of neutralizing antibodies
against HIV-1 viruses in HLA-DQ mice.
Vaccine 16:1537-1543, 1998 (IF=2.8)
Fukui Y, Ishimoto T, Utsuyama M, Gyotoku T, Koga T, Nakao K, Hirokawa K, Katsuki
M, Sasazuki T
Positive and negative CD4+ thymocyte selection by a single MHC classII/peptide ligand affected by
its expression level in the thymus.
Immunity 6:401-410, 1997 (IF=15.4)
Fukui Y, Yamamoto K, Koga T, Yamane K, Sasazuki T
Differential requirement of MHC class I molecules expressed on haematopoietic
cells for positive selection of CD4+ thymocytes in TCRαβ and TCRβ transgenic mice.
Int. Immunol. 9:1385-1391,1997 (IF=3.5)
Ishimoto T, Yamamoto K, Fukui Y, Fukuda Y, Dohi K, Sasazuki T
In vitro and in vivo evidence for high frequency of I-Ab-reactive CD4+ T cells in HLA-DQ or HLA-DRA transgenic mice lacking MHC class I and/or
class II expression
J. Immunol. 159:3717-3722, 1997 (IF=6.5)
Takeshita T, Fukui Y, Yamamoto K, Yamane K, Inamitsu T, Kamikawaji N, Sasazuki T
Identification of HLA-DQ-derived peptide recognized by mouse MHC class I H-2Db-restricted CD8+ T cells in HLA-DQ6 transgenic mice.
J. Human Genet. 42:225-232, 1997 (IF=2.3)
Yamamoto K, Fukui Y, Esaki Y, Inamitsu T, Sudo T, Yamane K, Kamikawaji N, Kimura A, Sasazuki T
Functional interaction between human histocompatibility leukocyte antigen
(HLA) class II and mouse CD4 molecule in antigen recognition by T cells
in HLA-DR and DO transgenic mice.
J. Exp. Med. 180:165-171, 1994 (IF=14.6)
Esaki Y, Fukui Y, Sudo T, Yamamoto K, Inamitsu T, Nishimura Y, Hirokawa K, Kimura A, Sasazuki
T
Role of human major histocompatibility complex DQ molecules in superantigenicity
of of Streptococcus-derived protein.
Infect. Immun. 62:1228-1235, 1994 (IF=4.0)
Fukui Y, Yamamoto K, Yokoyama N, Iwanaga T, Kurashima C, Esaki Y, Kimura A, Akashi
T, Hirokawa K, Sasazuki T
Restricted expression of transgenic HLA-DRA gene in thymic epithelial cells
and its role in acquisition of T cell tolerance to self-superantigens and
processed DR-derived peptide.
Eur. J. Immunol. 23:1678-1686, 1993 (IF=5.0)
Fukui Y, Ezaki Y, Kimura A, Hirokawa K, Nishimura Y, Sasazuki T
T cell repertoire in a strain of transgenic C57BL/6 mice with HLA-DRA gene
on the X chromosome.
Immunogenetics 37:204-211, 1993 (IF=2.9)
Esaki I, Kaneda H, Sakai K, Fukui Y, Singu M, Nobunaga M, Watanabe T
Restricted diversity of the variable region nucleotide sequences of the
heavy and light chains of a human rheumatoid factor.
Arthritis and Rheumatism 34:343-350, 1991 (IF=7.4)
Todd JA, Fukui Y, Kitagawa T, Sasazuki T
The A3 allele of the HLA-DQA1 locus is associated with susceptibility to
type 1 diabetes in Japanese.
Proc. Natl. Acad. Sci., USA 87:1094-1098, 1990 (IF=10.5)
Fukui Y, Nishimura Y, Iwanaga T, Kimura A, Inamitsu T, Hanaoka Y, Kitagawa T, Sasazuki T
Glycosuria and insulitis in NOD mice expressing the HLA-DQw6 molecule.
J. Immunogenet. 16:445-453, 1989
総説
國村 和史、福井 宣規：薬剤性アナフィラキシーに関わるMRGPRX2/B2受容体を介したマスト細胞の脱顆粒制御機構、月刊 臨床免疫・アレルギー科(科学評論社) 第80巻・第6号、2023
國村 和史、福井 宣規：アトピー性皮膚炎におけるIL-31の産生制御機構、月刊 皮膚科 (科学評論社) 第4巻・第3号、2023
國村和史、福井宣規
創薬標的としてのＩL-31の分子基盤：DOCK8と転写因子EPAS1
臨床免疫・アレルギー科 (科学評論社)、第77巻・第3号、2022
Kunimura K, Fukui Y
The molecular basis for IL-31 production and IL-31-mediated itch transmission
: from biology to drug development.
Int. Immunol. 33:731-736, 2021 (IF=4.8)
Kunimura K, Uruno T, Fukui Y
DOCK family proteins : key players in immune surveillance mechanisms.
Int. Immunol. 32:5-15, 2020 (IF=4.8)
Furue M, Yamamura K, Kido-Nakahara M, Nakahara T, Fukui Y
Emerging role of interleukin-31 and interleukin-31 receptor in pruritus
in atopic dermatitis.
Allergy 73:29-36, 2018 (IF=13.1)
宇留野武人、福井宣規
免疫抑制剤開発の新しい分子標的としてのDOCK2
実験医学、32：330‐335、2014
福井宣規
新たな免疫抑制剤開発標的としてのRac活性化因子DOCK2
細胞工学、32:1227-1231、2013
Nishikimi A, Kukimoto-Niino M, Yokoyama S, Fukui Y
Immune regulatory functions of DOCK family proteins in health and disease.
Exp. Cell. Res., 319:2343-2349, 2013
實松史幸、福井宣規
心血管形成におけるDOCK180の機能とその制御機構
感染・炎症・免疫、42:50-53、2013
福井宣規
免疫系細胞高次機能を司るCDMファミリー分子DOCK2
感染・炎症・免疫、39:20-29、2010
錦見昭彦、福井宣規
２つのリン脂質を介した好中球遊走におけるDOCK2細胞内動態の連続的制御
細胞工学、28:824-825、2009
田中芳彦、後藤和人、福井宣規
樹状細胞の遊走を制御するCDMファミリー分子DOCK2
実験医学、26:53-58、2008
福井宣規
好中球遊走を制御するRac活性化分子DOCK2
実験医学、24:3269-3276、2006
福井宣規
リンパ球の運動性を制御する分子DOCK2
医学のあゆみ、11: 2915-2920、2005
福井宣規
MHCによる免疫システムの構築
ゲノム医学、4: 331-336、2004
讃井彰一、福井宣規
CDMファミリー分子DOCK2による免疫シナプス形成の制御
細胞工学、22: 1204-1207、2003
讃井彰一、福井宣規
免疫応答におけるリンパ球の動態-HCH欠損マウスの情報-
感染・炎症・免疫,33:52-54、2003
福井宣規
CDMファミリー分子DOCK2によるリンパ球遊走の制御
Molecular Medicine 増刊「免疫2003」39:22-30、2002
福井宣規
リンパ球遊走に不可欠なCDMファミリー分子DOCK2
蛋白質核酸酵素増刊「免疫研究の最前線：高次複雑免疫システムの包括的理解をめざして」47: 2194-2199、2002
讃井彰一、福井宣規、笹月健彦
CDMファミリー分子DOCK2によるリンパ球遊走の制御
Medical Science Digest 28:550-551、2002
福井宣規
リンパ球遊走、ホーミングの制御機構
医学のあゆみ増刊「免疫疾患?state of arts」342-346、2002
福井宣規
CDMファミリー分子DOCK2によるリンパ球遊走の制御
細胞工学、20:1549-1551、2001
福井宣規
リンパ球遊走に不可欠なCDMファミリー分子DOCK2
実験医学、19:2409-2414、2001
福井宣規
胸腺内Ｔ細胞のセレクション
血液・免疫・腫瘍 BIC Forum別冊、14:41-48、1999
福井宣規
胸腺Ｔ細胞の正と負の選択
遺伝子医学、3:94-100、1999
福井宣規、笹月健彦
胸腺内Ｔ細胞の正の選択におけるTCR-MHC-ペプチド相互作用
Molecular Medicine 増刊「免疫1998-99」、35:56-64、1998
福井宣規
MHCクラスⅡ／ペプチド複合体の形成とそのＴ細胞受容体による認識
実験医学増刊「免疫研究の最前線'97?'98」15:86-93,199
福井宣規
MHC class I
Molecular Medicine 増刊号ノックアウトマウス・データブック、34:324-325、1997
福井宣規
胸腺Ｔ細胞の正と負の選択におけるＴ細胞レセプターとMHC／抗原ペプチド複合体との相互作用
臨床免疫、28:1363-1370、1996
福井宣規、笹月健彦
HLAトランスジェニックマウス
Medical Immunology 21:687-698、1991
福井宣規、笹月健彦
IDDMの成因と分子生物学-HLA遺伝子とIDDMの発症-
Diabetes Frontier、35-41、1991
福井宣規、西村泰治、笹月健彦
遺伝要因としてのHLA
ホルモンと臨床、39:3-11、1991
福井宣規
インスリン依存性糖尿病
細胞工学、8:973-980、1990
著書
福井宣規
T細胞レセプターとMHC分子
「免疫学イラストレイテッド」高津聖志・清野宏・三宅健介 監訳、105-124,
2009
福井宣規
抗原提示細胞
「戸田新細菌学」吉田眞一・柳 雄介・吉開泰信編、南山堂、390-399, 2007
福井宣規
Ｔ細胞による抗原の認識
「エッセンシャル免疫学」笹月健彦 監訳、67-96, 2007
Sakaguchi S, Hori S, Fukui Y, Sasazuki T, Sakaguchi N, Takahashi T
Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological serf-tolerance.
Novartis Found Symp., 252:6-16, 2003
Sasazuki T, Fukui Y
Contribution of MHC and non-MHC loci to the susceptibility to the organ-specific
autoimmune disease.
Allergy & Clinical Immunology Supplement (Hogrefe & Huber Publishers). 2000
Sasazuki T, Fukui Y
Positive and negative CD4+ thymocyte selection by a single MHC class II/peptide ligand invivo.
HLA 1996 (Oxford University Press). 1997
福井宣規、笹月健彦
遺伝子導入で動物を作り変える
「免疫工学の進歩」多田富雄・谷口克編、医学書院、pp1-8,1993
Fukui Y, Esaki Y, Yasunami M, Kimura A, Hirokawa K, Nishimura Y, Sasazuki T
T cell repertoire and self-tolerance in the transgenic mice with HLA-DRAon X chromosome.
HLA 1991 vol.II(Tsuji K, Aizawa M, Sasazuki
T. eds.) pp648-650, Oxford University Press, Oxford, 1992
Esaki Y, Fukui Y, Yasunami M, Kimura A, Hirokawa K, Sasazuki T
Functional expression of HLA-DQ4 genes in a line of transgenic C57BL/6 mouse.
HLA 1991 vol.II(Tsuji K, Aizawa M, Sasazuki T. eds.) pp651-653, Oxford University
Press, Oxford, 1992