{"id":947,"date":"2026-06-12T16:53:46","date_gmt":"2026-06-12T07:53:46","guid":{"rendered":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/?post_type=informationen&#038;p=947"},"modified":"2026-06-12T16:53:46","modified_gmt":"2026-06-12T07:53:46","slug":"the-research-paper-from-the-kurumizaka-lab-has-been-published-in-the-communications-biology","status":"publish","type":"informationen","link":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/archives\/informationen\/the-research-paper-from-the-kurumizaka-lab-has-been-published-in-the-communications-biology","title":{"rendered":"The research paper from the Kurumizaka Lab has been published in the Communications Biology!"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation and alters its dynamics<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ayako Furukawa, Kenta Echigoya, Samuel Blazquez, Masatoshi Wakamori, Hideaki Ohtomo, Yasuo Tsunaka, Takashi Umehara, Tsuyoshi Terakawa, Yoshimasa Takizawa, Hitoshi Kurumizaka, Yoshifumi Nishimura<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract<\/strong><br>The nucleosome is the fundamental chromatin unit, containing two copies of histones H2A, H2B, H3, and H4 wrapped by ~146 bp of core DNA plus linker DNA; addition of linker histone H1 forms a chromatosome. Tetra-acetylation of the H4 N-terminal tail (H4-4Kac) enhances H3 N-tail acetylation by altering their mutual dynamics, but how H1 influences these dynamics remains unclear. Using cryo-electron microscopy and coarse-grained molecular dynamics simulations, we show that H4-4Kac and unmodified chromatosomes share essentially identical core histone\u2013DNA structures and similar H3 N-tail dynamics. However, nuclear magnetic resonance spectroscopy reveals that in the H4-4Kac chromatosome, the H3 N-tail adopts a dynamically robust DNA-contact state distinct from that in the unmodified chromatosome, resulting in markedly reduced H3 N-tail acetylation. These findings suggest that linker histone H1 suppresses the progression of euchromatin formation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>Communications Biology<\/em><\/strong>, 9, 496. doi: 10.1038\/s42003-026-09926-y. (2026)<br><a href=\"https:\/\/www.nature.com\/articles\/s42003-026-09926-y\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.nature.com\/articles\/s42003-026-09926-y<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Linker histone H1 represses H3 tail acetylation induced by H4 tail acetylation a &#8230; <\/p>\n","protected":false},"author":2,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-947","informationen","type-informationen","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen"}],"about":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/types\/informationen"}],"author":[{"embeddable":true,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/users\/2"}],"version-history":[{"count":1,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/947\/revisions"}],"predecessor-version":[{"id":948,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/947\/revisions\/948"}],"wp:attachment":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/media?parent=947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}