{"id":863,"date":"2026-02-05T20:17:16","date_gmt":"2026-02-05T11:17:16","guid":{"rendered":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/?post_type=informationen&#038;p=863"},"modified":"2026-02-05T20:17:16","modified_gmt":"2026-02-05T11:17:16","slug":"a-new-preprint-from-the-fukaya-lab-has-been-posted-on-biorxiv-2","status":"publish","type":"informationen","link":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/archives\/informationen\/a-new-preprint-from-the-fukaya-lab-has-been-posted-on-biorxiv-2","title":{"rendered":"A new preprint from the Fukaya Lab has been posted on bioRxiv!"},"content":{"rendered":"\n<p><strong>The Drosophila ZAD zinc finger protein Mulberry shapes the organization of the regulatory genome in the early embryo<\/strong><\/p>\n\n\n\n<p>Yusuke Umemura, Takashi Fukaya<\/p>\n\n\n\n<p><strong>Abstract<\/strong><br>Long-range regulatory interactions play a fundamentally important role in the control of gene activity during animal development, yet the underlying mechanisms remain largely unclear. Here, we identified a zinc finger-associated domain (ZAD)-C2H2 zinc finger protein, CG31365\/Mulberry, as a looping factor that mediates long-range tethering activity in the early Drosophila embryo. Evidence is provided that Mulberry is specifically recruited to a subset of loop anchors and topological boundaries at key developmental loci to shape genome organization and gene activity. Super-resolution imaging analysis revealed that Mulberry forms nuclear condensates that associate with its target loci through the structured N-terminal ZAD domain. Micro-C analysis further demonstrated that the formation of loops and boundaries is lost in the condensation-deficient Mulberry mutant in a locus-specific manner. We propose that Mulberry acts as a condensation-dependent structural regulator of genome topology, organizing &#8220;multi-way regulatory hubs&#8221; that mediate long-range gene activation during early embryogenesis.<\/p>\n\n\n\n<p><strong><em>bioRxiv<\/em><\/strong>, doi: 10.64898\/2026.02.03.703437. (2026)<br><a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.02.03.703437v1\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.biorxiv.org\/content\/10.64898\/2026.02.03.703437v1<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Drosophila ZAD zinc finger protein Mulberry shapes the organization of the r &#8230; <\/p>\n","protected":false},"author":2,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-863","informationen","type-informationen","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen"}],"about":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/types\/informationen"}],"author":[{"embeddable":true,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/users\/2"}],"version-history":[{"count":1,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/863\/revisions"}],"predecessor-version":[{"id":864,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/863\/revisions\/864"}],"wp:attachment":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/media?parent=863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}