{"id":618,"date":"2025-07-11T16:11:45","date_gmt":"2025-07-11T07:11:45","guid":{"rendered":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/?post_type=informationen&#038;p=618"},"modified":"2025-07-11T16:11:45","modified_gmt":"2025-07-11T07:11:45","slug":"the-research-paper-from-the-hattori-lab-has-been-published-in-the-embo-reports","status":"publish","type":"informationen","link":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/archives\/informationen\/the-research-paper-from-the-hattori-lab-has-been-published-in-the-embo-reports","title":{"rendered":"The research paper from the Hattori Lab has been published in the EMBO Reports!"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Growth phase diets diminish histone acetyltransferase Gcn5 function and shorten lifespan of Drosophila males<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Shoko Mizutani, Kanji Furuya, Ayumi Mure, Yuuki Takahashi, Akihiro Mori, Nozomu Sakurai, Takuto Suito, Kohjiro Nagao, Masato Umeda, Kaori Watanabe, Yukako Hattori, and Tadashi Uemura<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract<\/strong><br>The nutritional environment in early life, referred to as the nutrition history, exerts far-reaching health effects beyond the developmental stage. Here, with Drosophila melanogaster as a model, we fed larvae on diets consisting of a variety of yeast mutants and explored the resulting histories that impacted adult lifespan. A larval diet comprised of yeast nat3 KO shortened the lifespan of male adults; and remarkably, this diet diminished the function of histone acetyltransferase Gcn5 in larvae. Concordantly, perturbation of Gcn5-mediated gene regulation in the larval whole body or neurons significantly contributed to the earlier death of adults. The nat3 KO diet is much more abundant in long-chain fatty acids and branched-chain amino acids (BCAAs) than the control yeast diet. Supplementing the control diet with a combination of oleic acid, valine, and acetic acid recapitulated the effects of the nat3 KO diet on the larval transcriptome and the lifespan of males. Our findings strongly suggest a causal link between a fatty acids- and BCAA-rich diet in developmental stages and lifespan reduction via the adverse effect on the Gcn5 function.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>EMBO Reports<\/em><\/strong>, doi: 10.1038\/s44319-025-00503-8. (2025)<br><a href=\"https:\/\/www.embopress.org\/doi\/full\/10.1038\/s44319-025-00503-8\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.embopress.org\/doi\/full\/10.1038\/s44319-025-00503-8<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Growth phase diets diminish histone acetyltransferase Gcn5 function and shorten  &#8230; <\/p>\n","protected":false},"author":2,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-618","informationen","type-informationen","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen"}],"about":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/types\/informationen"}],"author":[{"embeddable":true,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/users\/2"}],"version-history":[{"count":1,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/618\/revisions"}],"predecessor-version":[{"id":619,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/618\/revisions\/619"}],"wp:attachment":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/media?parent=618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}