{"id":449,"date":"2025-03-10T13:09:29","date_gmt":"2025-03-10T04:09:29","guid":{"rendered":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/?post_type=informationen&#038;p=449"},"modified":"2025-03-10T13:09:29","modified_gmt":"2025-03-10T04:09:29","slug":"the-review-paper-by-nakayama-lab-has-been-published-in-the-biochimica-et-biophysica-acta-general-subjects","status":"publish","type":"informationen","link":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/archives\/informationen\/the-review-paper-by-nakayama-lab-has-been-published-in-the-biochimica-et-biophysica-acta-general-subjects","title":{"rendered":"The review paper by Nakayama Lab has been published in the Biochimica et Biophysica Acta &#8211; General Subjects!"},"content":{"rendered":"\n<p><strong>Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin<\/strong><\/p>\n\n\n\n<p>Chikashi Obuse, Jun-ichi Nakayama<\/p>\n\n\n\n<p>Abstract<br>Heterochromatin is a highly condensed chromatin structure observed in the nuclei of eukaryotic cells. It plays a pivotal role in repressing undesired gene expression and establishing functional chromosomal domains, including centromeres and telomeres. Heterochromatin is characterized by specific histone modifications and the formation of higher-order chromatin structures mediated by proteins, such as HP1 and Polycomb repressive complexes (PRCs), which recognize the specific histone modifications. Recent studies have identified the involvement of non-coding RNAs (ncRNAs) and intrinsically disordered proteins (IDPs) in heterochromatin, leading to the proposal of a new model in which liquid-liquid phase separation (LLPS) contributes to heterochromatin formation and function. This emerging model not only broadens our understanding of heterochromatin&#8217;s molecular mechanisms but also provides insights into its dynamic regulation depending on cellular context. Such advancements pave the way for exploring heterochromatin&#8217;s role in genome organization and stability, as well as its implications in development and disease.<\/p>\n\n\n\n<p><strong><em>Biochimica et Biophysica Acta &#8211; General Subjects<\/em><\/strong>, doi: 10.1016\/j.bbagen.2025.130790. (2025)<br><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0304416525000352?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0304416525000352?via%3Dihub<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Functional involvement of RNAs and intrinsically disordered proteins in the asse &#8230; <\/p>\n","protected":false},"author":2,"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-449","informationen","type-informationen","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/449","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen"}],"about":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/types\/informationen"}],"author":[{"embeddable":true,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/users\/2"}],"version-history":[{"count":1,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/449\/revisions"}],"predecessor-version":[{"id":450,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/informationen\/449\/revisions\/450"}],"wp:attachment":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/media?parent=449"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}