{"id":861,"date":"2026-02-05T20:16:38","date_gmt":"2026-02-05T11:16:38","guid":{"rendered":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/?post_type=information&#038;p=861"},"modified":"2026-02-05T20:16:38","modified_gmt":"2026-02-05T11:16:38","slug":"%e6%b7%b1%e8%b0%b7%e8%a8%88%e7%94%bb%e7%a0%94%e7%a9%b6%e4%bb%a3%e8%a1%a8%e3%81%ab%e3%82%88%e3%82%8b%e6%88%90%e6%9e%9c%e3%81%8c-biorxiv%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97-2","status":"publish","type":"information","link":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/archives\/information\/%e6%b7%b1%e8%b0%b7%e8%a8%88%e7%94%bb%e7%a0%94%e7%a9%b6%e4%bb%a3%e8%a1%a8%e3%81%ab%e3%82%88%e3%82%8b%e6%88%90%e6%9e%9c%e3%81%8c-biorxiv%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c%e3%81%be%e3%81%97-2","title":{"rendered":"\u6df1\u8c37\u8a08\u753b\u7814\u7a76\u4ee3\u8868\u306b\u3088\u308b\u6210\u679c\u304c bioRxiv\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f!"},"content":{"rendered":"\n<p><strong>The Drosophila ZAD zinc finger protein Mulberry shapes the organization of the regulatory genome in the early embryo<\/strong><\/p>\n\n\n\n<p>Yusuke Umemura, Takashi Fukaya<\/p>\n\n\n\n<p><strong>Abstract<\/strong><br>Long-range regulatory interactions play a fundamentally important role in the control of gene activity during animal development, yet the underlying mechanisms remain largely unclear. Here, we identified a zinc finger-associated domain (ZAD)-C2H2 zinc finger protein, CG31365\/Mulberry, as a looping factor that mediates long-range tethering activity in the early Drosophila embryo. Evidence is provided that Mulberry is specifically recruited to a subset of loop anchors and topological boundaries at key developmental loci to shape genome organization and gene activity. Super-resolution imaging analysis revealed that Mulberry forms nuclear condensates that associate with its target loci through the structured N-terminal ZAD domain. Micro-C analysis further demonstrated that the formation of loops and boundaries is lost in the condensation-deficient Mulberry mutant in a locus-specific manner. We propose that Mulberry acts as a condensation-dependent structural regulator of genome topology, organizing &#8220;multi-way regulatory hubs&#8221; that mediate long-range gene activation during early embryogenesis.<\/p>\n\n\n\n<p><strong><em>bioRxiv<\/em><\/strong>, doi: 10.64898\/2026.02.03.703437. (2026)<br><a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.02.03.703437v1\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.biorxiv.org\/content\/10.64898\/2026.02.03.703437v1<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Drosophila ZAD zinc finger protein Mulberry shapes the organization of the r &#8230; <\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-861","information","type-information","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/information\/861","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/information"}],"about":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/types\/information"}],"version-history":[{"count":1,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/information\/861\/revisions"}],"predecessor-version":[{"id":862,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/information\/861\/revisions\/862"}],"wp:attachment":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/media?parent=861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}