{"id":620,"date":"2025-07-11T16:12:26","date_gmt":"2025-07-11T07:12:26","guid":{"rendered":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/?post_type=information&p=620"},"modified":"2025-07-11T16:19:02","modified_gmt":"2025-07-11T07:19:02","slug":"%e6%9c%8d%e9%83%a8%e8%a8%88%e7%94%bb%e7%a0%94%e7%a9%b6%e4%bb%a3%e8%a1%a8%e3%81%ab%e3%82%88%e3%82%8b%e6%88%90%e6%9e%9c%e3%81%8cembo-reports%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c","status":"publish","type":"information","link":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/archives\/information\/%e6%9c%8d%e9%83%a8%e8%a8%88%e7%94%bb%e7%a0%94%e7%a9%b6%e4%bb%a3%e8%a1%a8%e3%81%ab%e3%82%88%e3%82%8b%e6%88%90%e6%9e%9c%e3%81%8cembo-reports%e8%aa%8c%e3%81%ab%e6%8e%b2%e8%bc%89%e3%81%95%e3%82%8c","title":{"rendered":"\u670d\u90e8\u8a08\u753b\u7814\u7a76\u4ee3\u8868\u306b\u3088\u308b\u6210\u679c\u304cEMBO Reports\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f!"},"content":{"rendered":"\n

Growth phase diets diminish histone acetyltransferase Gcn5 function and shorten lifespan of Drosophila males<\/strong><\/p>\n\n\n\n

Shoko Mizutani, Kanji Furuya, Ayumi Mure, Yuuki Takahashi, Akihiro Mori, Nozomu Sakurai, Takuto Suito, Kohjiro Nagao, Masato Umeda, Kaori Watanabe, Yukako Hattori, and Tadashi Uemura<\/p>\n\n\n\n

Abstract<\/strong>
The nutritional environment in early life, referred to as the nutrition history, exerts far-reaching health effects beyond the developmental stage. Here, with Drosophila melanogaster as a model, we fed larvae on diets consisting of a variety of yeast mutants and explored the resulting histories that impacted adult lifespan. A larval diet comprised of yeast nat3 KO shortened the lifespan of male adults; and remarkably, this diet diminished the function of histone acetyltransferase Gcn5 in larvae. Concordantly, perturbation of Gcn5-mediated gene regulation in the larval whole body or neurons significantly contributed to the earlier death of adults. The nat3 KO diet is much more abundant in long-chain fatty acids and branched-chain amino acids (BCAAs) than the control yeast diet. Supplementing the control diet with a combination of oleic acid, valine, and acetic acid recapitulated the effects of the nat3 KO diet on the larval transcriptome and the lifespan of males. Our findings strongly suggest a causal link between a fatty acids- and BCAA-rich diet in developmental stages and lifespan reduction via the adverse effect on the Gcn5 function.<\/p>\n\n\n\n

EMBO Reports<\/em><\/strong>, doi: 10.1038\/s44319-025-00503-8. (2025)
https:\/\/www.embopress.org\/doi\/full\/10.1038\/s44319-025-00503-8<\/a><\/p>\n\n\n\n

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