{"id":447,"date":"2025-03-10T13:08:33","date_gmt":"2025-03-10T04:08:33","guid":{"rendered":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/?post_type=information&#038;p=447"},"modified":"2025-03-10T13:08:33","modified_gmt":"2025-03-10T04:08:33","slug":"%e4%b8%ad%e5%b1%b1%e8%a8%88%e7%94%bb%e7%a0%94%e7%a9%b6%e4%bb%a3%e8%a1%a8%e3%81%ab%e3%82%88%e3%82%8b%e7%b7%8f%e8%aa%ac%e3%81%8cbiochimica-et-biophysica-acta-general-subjects%e8%aa%8c%e3%81%ab","status":"publish","type":"information","link":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/archives\/information\/%e4%b8%ad%e5%b1%b1%e8%a8%88%e7%94%bb%e7%a0%94%e7%a9%b6%e4%bb%a3%e8%a1%a8%e3%81%ab%e3%82%88%e3%82%8b%e7%b7%8f%e8%aa%ac%e3%81%8cbiochimica-et-biophysica-acta-general-subjects%e8%aa%8c%e3%81%ab","title":{"rendered":"\u4e2d\u5c71\u8a08\u753b\u7814\u7a76\u4ee3\u8868\u306b\u3088\u308b\u7dcf\u8aac\u304cBiochimica et Biophysica Acta &#8211; General Subjects\u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f!"},"content":{"rendered":"\n<p><strong>Functional involvement of RNAs and intrinsically disordered proteins in the assembly of heterochromatin<\/strong><\/p>\n\n\n\n<p>Chikashi Obuse, Jun-ichi Nakayama<\/p>\n\n\n\n<p><strong>Abstract<\/strong><br>Heterochromatin is a highly condensed chromatin structure observed in the nuclei of eukaryotic cells. It plays a pivotal role in repressing undesired gene expression and establishing functional chromosomal domains, including centromeres and telomeres. Heterochromatin is characterized by specific histone modifications and the formation of higher-order chromatin structures mediated by proteins, such as HP1 and Polycomb repressive complexes (PRCs), which recognize the specific histone modifications. Recent studies have identified the involvement of non-coding RNAs (ncRNAs) and intrinsically disordered proteins (IDPs) in heterochromatin, leading to the proposal of a new model in which liquid-liquid phase separation (LLPS) contributes to heterochromatin formation and function. This emerging model not only broadens our understanding of heterochromatin&#8217;s molecular mechanisms but also provides insights into its dynamic regulation depending on cellular context. Such advancements pave the way for exploring heterochromatin&#8217;s role in genome organization and stability, as well as its implications in development and disease.<\/p>\n\n\n\n<p><strong><em>Biochimica et Biophysica Acta &#8211; General Subjects<\/em><\/strong>, doi: 10.1016\/j.bbagen.2025.130790. (2025)<br><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0304416525000352?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0304416525000352?via%3Dihub<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Functional involvement of RNAs and intrinsically disordered proteins in the asse &#8230; <\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"","format":"standard","meta":{"footnotes":""},"class_list":["post-447","information","type-information","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/information\/447","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/information"}],"about":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/types\/information"}],"version-history":[{"count":1,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/information\/447\/revisions"}],"predecessor-version":[{"id":448,"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/information\/447\/revisions\/448"}],"wp:attachment":[{"href":"https:\/\/www.bioreg.kyushu-u.ac.jp\/ext\/epicode\/wp-json\/wp\/v2\/media?parent=447"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}