九州大学 生体防御医学研究所

下記の通り、R. Manjunatha Kini先生によるセミナーを開催します。皆様のご来聴を心より歓迎致します。

※セミナーは英語で行われます。(Seminar in English)

演題 / Title

Venom and Toxin Research: Biochemist’s Bliss and Pharmacologist’s Paradise

演者 / Speaker

Prof. R. Manjunatha Kini (Ph.D.)
Department of Biological Sciences,
Faculty of Science, National University of Singapore, Singapore

日時 / Date

2019年11月5日（火） Nov. 5 (Tue), 2019
17：00〜18：30

場所 / Venue

病院キャンパス　生体防御医学研究所 本館1階 会議室
以下の地図の29番です。
（http://www.kyushu-u.ac.jp/f/35767/2019hospital_2.pdf）

Seminar Room, Main Building 1F, Medical Institute of Bioregulation, Hospital Campus
No.29 on the following linked map.
（http://www.kyushu-u.ac.jp/f/35768/2019hospital-en_2.pdf）

要 旨 / Abstract

Venoms form the armory of several animals in prey capture and/or predator deterrence. They have evolved as cocktails of several toxins and induce various pharmacological effects in key systems. These toxins are thought as villains as they cause death and debilitation. In reality, they have contributed more to improving our lives than cause death. Toxins have played crucial roles in the discovery and development of therapeutic and diagnostic agents for human diseases. They have also contributed as important research tools and helped us to understand molecular mechanisms of normal physiological processes such as neurotransmission, blood coagulation and platelet aggregation. Our lab in NUS has been studying structure-function relationships and mechanism of actions of novel toxins from various sources. Our research has contributed to both basic and applied sciences. Based on the functional sites of the toxins, we have developed several therapeutic agents for various human diseases. This talk will provide an overview of toxin research and the distinct dimension of both basic and applied research in the field.

参考論文 / References

1. Sridharan S, Kini RM.
   Decoding the molecular switches of natriuretic peptides which differentiate its vascular and renal functions.
   Biochem J. 475(2):399-413 (2018).
2. Iyer JK, Koh CY, Kazimirova M, Roller L, Jobichen C, Swaminathan K, Mizuguchi J, Iwanaga S, Nuttall PA, Chan MY and Kini RM.
   Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum.
   FASEB J. 31(17): 2981-2995 (2017).
3. Sridharan S, Kini RM.
   Tail wags the dog: activity of krait natriuretic peptide is determined by its C-terminal tail in a natriuretic peptide receptor-independent manner.
   Biochem J. 469(2):255-66 (2015).
4. Koh CY, Kazimirova M, Trimnell A, Takac P, Labuda M, Nuttall PA and Kini, RM.
   Variegin, a novel fast and tight binding thrombin inhibitor from the tropical bont tick.
   J Biol Chem. 282(40): 29101-13 (2007).

連絡先 / Contact

生体防御医学研究所　ゲノミクス分野
柴田 弘紀

Division of Genomics, Medical Institute of Bioregulation
Hiroki Shibata

TEL: 092 (642) 6168
Email: hshibata@gen.kyushu-u.ac.jp