第782回 生医研セミナー(多階層生体防御システム研究拠点)

下記の通り、Eunhee Kim 先生によるセミナーを開催致します。皆様のご来聴を心より歓迎いたします。

※セミナーは英語で行われます。(Seminar in English)


演題 / Title

First-in-class drug development strategy for Parkinson’s disease via interruption of death signaling

演者 / Speaker

Dr. Eunhee Kim

Department of Biological Sciences, Chungnam National University, Daejeon 34134, Korea,
Visiting Professor, MIB

日時 / Date

2018年11月21日(水) Nov. 21(Wed), 2018
15:00~16:30

場所 / Venue

病院キャンパス 生体防御医学研究所 本館1階 会議室
以下の地図の31番です。
(http://www.kyushu-u.ac.jp/f/33951/2018hospital_2.pdf)

Seminar Room, 1F, Main Building, Medical Institute of Bioregulation, Hospital Campus
No.31 on the following linked map.
(http://www.kyushu-u.ac.jp/f/33952/2018hospital_2-en.pdf)

要 旨 / Abstract

Fas-associated factor 1 (FAF1), a death–promoting protein, plays disease-promoting roles in neurodegenerative diseases, especially the Parkinson’s disease (PD). PD is the second most common neurodegenerative disease characterized by the selective loss of dopaminergic neurons. FAF1 expression was increased in the PD patients’ brains, leading us to explore FAF1’s role in the pathogenesis of PD. We identified FAF1 as a substrate of Parkin and found that FAF1 promotes α-synuclein accumulation, demonstrating the presence of Parkin–FAF1–α-synuclein signaling axis. FAF1 drove dopaminergic neuronal death by programmed necrosis as well as apoptosis upon oxidative stress. Such characteristic portrayed FAF1 as an advantageous drug target over proteins driving single type of cell death. Subsequently, we screened FAF1 inhibitory compounds and developed a compound targeting FAF1 (CTF), a first-in-class small molecule, and performed pre-clinical study. CTF demonstrated excellent efficacies in cell and in vivo models. At present, the molecule completed phase I clinical trial.

[This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HI16C0947)]

連絡先 / Contact

生体防御医学研究所 脳機能制御学分野
中別府 雄作
092(642)6800

Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation
Yusaku Nakabeppu
TEL: 092(642)6800