第759回 生医研セミナー(多階層生体防御システム研究拠点)


下記の通り、岡田 誠司 先生によるセミナーを開催致します。皆様方のご参加を心よりお待ちしております。

※セミナーは英語で行われます。(Seminar in English)

演題 / Title

Spinal cord regeneration based on glial biology

演者 / Speaker

岡田 誠司 先生
九州大学医学研究院 先端医療医学部門 准教授

Seiji Okada, M.D., Ph.D.
Associate Professor, Dept.of Advanced Medical Initiatives
Graduate School of Medical Sciences, Kyushu University

日時 / Date

2018年1月29日(月)  Jan. 29 (Mon), 2018
9:30~10:30

場所 / Venue

病院キャンパス 生体防御医学研究所 本館1階 会議室
以下の地図の26番です。
(http://www.kyushu-u.ac.jp/f/30078/Hospital_jp-2017.pdf)

Seminar Room, Main Building 1F, Medical Institute of Bioregulation
No.26 on the following linked map.
(http://www.kyushu-u.ac.jp/f/30074/Hospital_en-2017.pdf)

要 旨 / Abstract

In recent years, stem cell transplantation has emerged as a potential therapeutic strategy for spinal cord injury (SCI), and several early-phase clinical trials have been completed. However, its efficacy and long-term safety remain unproven, especially in the chronic transplantation for SCI. One of the failure causes can be ascribed to the glial scar, which strictly segregates the lesion and the spared area after SCI. The process of glial scar formation, astrogliosis, has long been considered to be unidirectional and irreversible, however, we recently demonstrated that the process of glial scar formation is regulated by environmental cues, such as fibrotic extracellular matrix material. In this seminar, I will talk about the new concept for spinal cord regeneration based on glial biology.

業績 / Publications

Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T, Kijima K, Harimaya K, Nakashima Y, Okada S*. Interaction of reactive astrocytes with collagen type I induces astrocytic scar formation through the integrin/N-cadherin pathway after spinal cord injury. Nature Medicine. 23:818-28, 2017.

Koabayakawa K, Kumamaru H, Saiwai H, Kubota K, Ohkawa Y, Yokota K, Ideta R, Shiba K, Inoue K, Iwamoto Y, Okada S*. Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans. Science Transl. Med. 6:256ra137, 2014.

連絡先 / Contact

生体防御医学研究所
中別府 雄作 092(642)6800

Medical Institute of Bioregulation, Yusaku Nakabeppu
Tel:092-642-6800