第761回 生医研セミナー(多階層生体防御システム研究拠点)


下記の通り、伊藤 貴浩 先生によるセミナーを開催致します。皆様方のご参加を心よりお待ちしております。

※セミナーは英語で行われます。(Seminar in English)

演題 / Title

Don’t misbehave: reprogramming cell fates in the regulation of stem cells and cancer

演者 / Speaker

伊藤 貴浩 先生
ジョージア大学 生化学分子生物学部 助教授

Takahiro Ito, Ph.D.
Assistant Professor
University of Georgia, Department of Biochemistry & Molecular Biology

日時 / Date

2018年1月29日(月)  Jan. 29 (Mon), 2018
14:30~15:30

場所 / Venue

病院キャンパス 生体防御医学研究所 本館1階 会議室
以下の地図の26番です。
(http://www.kyushu-u.ac.jp/f/30078/Hospital_jp-2017.pdf)

Seminar Room, Main Building 1F, Medical Institute of Bioregulation
No.26 on the following linked map.
(http://www.kyushu-u.ac.jp/f/30074/Hospital_en-2017.pdf)

要 旨 / Abstract

Stem cells and cancer share a characteristic ability of self-renewal, which is essential for long-term maintenance of both cell types in vivo. Similar to a hierarchy of stem and progenitor cells in normal tissues, many types of tumors are maintained by a population of self-renewing cancer cells while the bulk of the tumor is consisted of more differentiated cells with no or limited renewal activity. The self-renewing cancer cells, or tumor-initiating cells, are often resistant to conventional therapies and thereby mediate tumor relapse and provide a basis for cancer progression. Because the ability to self-renew is modulated via cell fate decision, the regulatory mechanisms of stem cell fates have emerged as one of the promising areas for targeted cancer therapies. We are particularly interested in the cell fate regulatory circuits governed by RNA binding proteins and cell metabolism, and I would like to share our recent findings on how these factors maintain self-renewal potential and contribute to cancer progression.

業績 / Publications

Hattori A. et al. Cancer progression by reprogrammed BCAA metabolism in myeloid leukemia. Nature 545, 500-504 (2017)

連絡先 / Contact

生体防御医学研究所
中別府 雄作 092(642)6800

Medical Institute of Bioregulation, Yusaku Nakabeppu
Tel:092-642-6800