第727回 生医研セミナー(多階層生体防御システム研究拠点)
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下記の通り、Chukwuemeka George Anene-Nzelu先生によるセミナーを開催致します。 多くの方々のご来聴をお待ちしております。
演題
Role of OGG1-dependent DNA repair in stress-induced heart failure
演者
Dr. Chukwuemeka George Anene-Nzelu
Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore
日時
2016年12月9日（金） Dec. 9(Fri), 2016
14：00 ～15：30
場所
病院キャンパス内 総合研究棟 1階 101
以下の地図の1番です。
（https://www.kyushu-u.ac.jp/f/28545/hospital_jp.pdf）
Seminar Room101, 1F, Biomedical Research Station
No.1 on the following linked map.
（https://www.kyushu-u.ac.jp/f/28551/hospital_en.pdf）
要 旨
Heart failure is associated with high levels of DNA damage and defective repair due to oxidative stress. 8-oxoguanine (8-oxoG) is one of the most common DNA lesions in heart failure and its presence has been correlated to mutations, apoptosis and mitochondrial dysfunction. The principal base excision repair enzyme responsible for repair of this DNA damage is OGG1 and its expression has been shown to be reduced in heart failure. We are elucidating the role of OGG1 in stress-induced heart failure and repair by using Ogg1-/- mice. Heart failure in the mice is induced using a pressure-overload model of transverse aortic constriction (TAC) and we compare the progression of heart failure in the knock out mice with wild type mice. First we are employing RNA-Seq and qPCR to look at the effect of OGG1 loss on cardiac transcriptome. Cardiac Echocardiography is used to assess important physiological parameters such as ejection fraction, fractional shortening and wall dimensions. In addition histological stains are used to evaluate fibrosis and hypertrophy.
連絡先
生体防御医学研究所 脳機能制御学分野
中別府 雄作 092(642)6800