|下記のとおり、Eckhard R. Podack博士によるセミナーを開催致します。多くの皆様のご来聴をお待ちしております。
|場所||馬出医学系キャンパス内 総合研究棟 セミナー室 １０５ （１階）
|演題||TNFRSF25 in vaccination
|演者||Eckhard R. Podack, M.D., Ph.D.
Professor and Chairman of Microbiology and Immunology
University of Miami Miller School of Medicine
|要旨||FoxP3+ Tregs are composed of nTreg cells generated in the thymus with TCR specificities for self antigen and of inducible iTreg cells which have TCRs specificities for non-self or foreign antigens. We recently identified TNFRSF25 as a powerful regulator of Treg proliferation in vivo downstream of TCR and IL-2 signals, however it remained unclear whether both nTreg and iTreg cells were responsive to TNFRSF25-triggered proliferation. Here we provide evidence that in vitro generated iTregs unlike nTregs after adoptive transfer do not proliferate in response to TNFRSF25 signaling. In contrast, both in vivo induced polyclonal iTreg and TCR transgenic iTreg proliferate in response to TNFRSF25 signaling in a cognate antigen dependent fashion. TNFRSF25 induced iTreg proliferation is especially strong in mesenteric lymph nodes. These studies demonstrate that both nTreg and iTreg require cognate-antigen to respond to TNFRSF25 induced proliferation and that cognate antigen for iTreg is more abundant in gut associated lymphoid tissue, which is also a preferential site of FoxP3 induction and iTreg accumulation.
Schreiber TH, Wolf D, Tsai MS, Chirinos J, Deyev VV, Gonzalez L, Malek TR, Levy RB, Podack ER. Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J Clin Invest. 2010 120:3629-40
Podack ER. How to polymerize in order to survive. Immunity. 2009 3:668-70
- Fang L, Adkins B, Deyev V, Podack ER.Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation. J Exp Med. 2008 205:1037-48.