この度、生体防御医学研究所・防御分子構築学分野・客員准教授に選任されました千葉大学大学院医学研究院・薬理学の松本明郎博士に生体防御医学研究所でのセミナーをお願いしました。
セミナーでは、生体サンプルの一酸化窒素(NO)とNO誘導体の検出と測定方法を中心にご講演いただきます。講演は英語で行われます。皆様是非ご来聴下さい。
The speaker will give his lecture in English. Please join us on this occasion.
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| 日時 | 平成２３年１月２７日（木）１４時〜１６時 |
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| 場所 | 馬出医学系キャンパス内 生体防御医学研究所 本館１階 会議室
Medical Institute of Bioregulation, Main Building 1F, Seminar Room
以下の地図の20番になります。
（http://www.kyushu-u.ac.jp/access/map/hospital/hospital.html）
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| 演題 | Detection and measurement of NO and its derivatives in biological samples
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| 演者 | 松本 明郎 先生
千葉大学大学院医学研究院 薬理学 准教授
Dr. Akio Matsumoto (Associate Professor, Department of Pharmacology, Graduate School of Medicine, Chiba University)
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| 要旨 |
Physiological cellular regulation is achieved through a highly complicated signal transduction system with a myriad of signal elements that allow adaptation to various environmental changes in well-governed stimulus-response mechanisms. Besides roles of messenger molecules that transduce and refine signals, modifications on signal element provide further potential to adapt abrupt environmental changes.
Nitric oxide (NO) is a unique molecule in signaling since it works as both a second messenger and a modifier of signal component. Moreover, enzymatic NO production in biological system reflects environmental changes resulting in the alteration of NO availability, thus NO-based regulatory system on signal transduction has an advantage to reflect environmental changes in signaling through two ways, signal transmission and signal modification.
Investigation of regulatory mechanism in signaling by NO has wide application in biological science; however, NO itself requires higher attention on its nature when handling and measuring its activities in biological materials. This seminar initially provides basic concept on NO in chemistry and biochemistry, with focus on synthesis and decomposition of NO. Then, will provide methods to detect and measure NO and its derivatives, with particular emphasis on factors to avoid technical glitches. Finally, an overview of therapeutic opportunities of NO and derivatives in human disease will be presented.
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| 連絡先 | 生体防御医学研究所 脳機能制御学分野
中別府 雄作
電話：092-642-6800 |
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