Associate Professor (Tokyo University) : Motoko Unoki
Original Research Papers
- Uemura, S., Maenohara, S., Inoue, K., Ogonuki, N., Matoba, S., Ogura, A., Kurumizaka, M., Yamagata, K., Sharif, J., Koseki, H., Ueda, K., Unoki, M. & Sasaki, H.
- UHRF1 is essential for proper cytoplasm architecture and function of mouse oocyte and derived embryo.
- Life Sci. Alliance 6:e202301904 (2023).
- Pubmed
- Unoki, M., Velasco, G., Kori, S., Arita, K., Daigaku, Y., Au Yeung, W.K., Fujimoto, A., Ohashi, H., Kubota, T., Miyake, K. & Sasaki, H.
- Novel compound heterozygous mutations in UHRF1 are associated with atypical immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome with distinctive genome-wide DNA hypomethylation.
- Hum. Mol. Genet. 32:1439-1456 (2023).
- Pubmed
- Haratake, N., Hu, Q., Okamoto, T., Jogo, T., Toyokawa, G., Kinoshita, F., Takenaka, T., Tagawa, T., Iseda, N., Itoh, S., Yamada, Y., Oda, Y., Shimokawa, M., Kikutake, C., Suyama, M., Unoki, M., Sasaki, H. & Mori, M.
- Identification of SLC38A7 as a prognostic marker and potentially targetable driver gene of lung squamous cell carcinoma.
- Ann. Surg. 274, 500-507 (2021)
- PubMed
- Velasco, G., Ulveling, D., Rondeau, S., Marzin, P., Unoki, M., Cormier-Daire, V., & Francastel, C.
- Interplay between histone and DNA Methylation seen through comparative methylomes in rare mendelian disorders.
- Int. J. Mol. Sci. 22, 3735 (2021)
- PubMed
- Morikawa, T., Ohishi, H., Kosaka, K., Shimojo T., Nagano, A., Taniguchi, I., Fujioka, R., Moriyama, K., Unoki, M., Takahashi, M., Nakao, M., Izumi, Y., Bamba, T., Sasaki, H., Miura, S. & Shibata, H.
- Ddhd1 knockout mouse as a model of locomotive and physiological abnormality in familial spastic paraplegia.
- Biosci. Rep. 41, BSR20204171 (2021)
- PubMed
- Unoki, M., Sharif, J., Saito, Y., Velasco, G., Francastel, C., Koseki, H. & Sasaki, H.
- CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats.
- Sci. Rep. 10, 17865 (2020)
- PubMed
- Kori, S.*, Jimenji, T.*, Ekimoto, T.*, Sato, M., Kusano, F., Oda, T., Unoki, M., Ikeguchi, M., & Arita, K. (*These authors equally contributed to the work.)
- Serine 298 phosphorylation in linker 2 of UHRF1 regulates ligand-binding property of its tandem Tudor domain.
- J. Mol. Biol. 432, 4061-4075 (2020)
- PubMed
- Ohishi, H.*, Au Yeung, W.K.*, Unoki, M., Ichiyanagi, K., Fukuda, K., Maenohara, S., Shirane, K., Chiba, H., Sado, T. & Sasaki, H. (*These authors equally contributed to the work.)
- Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells.
- Genes Cells 25, 54-64 (2020)
- PubMed
- Aktar, S., Sasaki, H. & Unoki, M.
- Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation.
- Genes Cells 24, 746-755 (2019)
- PubMed
- Unoki, M., Funabiki, H., Velasco, G., Francastel, C. & Sasaki, H.
- CDCA7 and HELLS mutations undermine non-homologous end joining in centromeric instability syndrome.
- J. Clin. Invest. 129, 78-92 (2019)
- PubMed
- Matsuda, S., Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotoh, K., Fukuda, K., Sasaki, H., Suzuki, T. & Kang, D.
- Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA.
- Sci. Rep. 8, 5801 (2018)
- PubMed
- Maenohara, S., Unoki, M., Toh, H., Ohishi, H., Sharif, J., Koseki, H. & Sasaki, H.
- Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos.
- PLoS Genet. 13, e1007042. (2017)
- PubMed
- Thijssen, P.E., Ito, Y., Grillo, G., Wang, J., Velasco, G., Nitta, H., Unoki, M., Yoshihara, M., Suyama, M., Sun, Y., Lemmers, R.J.L.F., de Greef, J.C., Gennery, A., Picco, P., Kloeckener-Gruissem, B., Gungor, T., Reisli, I., Picard, C., Kebaili, K., Roquelaure, B., Iwai, T., Kondo, I., Kubota, T., van Ostaijen-Ten Dam, M.M., van Tol, M.J.D., Weemaes, C., Francastel, C., van der Maarel, S.M. & Sasaki. H.
- Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.
- Nat. Commun. 6, 7870 (2015)
- PubMed
- Nitta, H., Unoki, M., Ichiyanagi, K., Kosho, T., Shigemura, T., Takahashi, H., Velasco, G., Francastel, C., Picard, C., Kubota, T. & Sasaki, H.
- Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients.
- J. Hum. Genet. 58, 455-460 (2013)
- PubMed
- Unoki, M., Masuda, A., Dohmae, N., Arita, K., Yoshimatsu, M., Iwai, Y., Fukui, Y., Ueda, K., Hamamoto, R., Shirakawa, M., Sasaki, H. & Nakamura, Y.
- Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6).
- J. Biol. Chem. 288, 6053-6062 (2013)
- PubMed
- Kofunato, Y., Kumamoto, K., Saitou, K., Hayase, S., Okayama, H., Miyamoto, K., Sato, Y., Katakura, K., Nakamura, I., Ohki, S., Koyama, Y., Unoki, M. & Takenoshita S.
- UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer.
- Oncol. Rep. 28, 1997-2002 (2012)
- PubMed
- Arita, K., Isogai, S., Oda, T., Unoki, M., Sugita, K., Sekiyama, N., Kuwata, K., Hamamoto, R., Tochio, H., Sato, M., Ariyoshi, M. & Shirakawa, M.
- Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.
- Proc. Natl. Acad. Sci. USA 109, 12950-12955 (2012)
- PubMed
- Cho, H.S., Suzuki, T., Dohmae, N., Hayami, S., Unoki, M., Yoshimatsu, M., Toyokawa, G., Takawa, M., Chen, T., Kurash, J.K., Field, H.I., Ponder, B.A., Nakamura, Y. & Hamamoto, R.
- Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.
- Cancer Res. 71, 655-660 (2011)
- PubMed
- Unoki, M., Daigo, Y., Koinuma, J., Tsuchiya, E., Hamamoto, R. & Nakamura Y.
- UHRF1 is a novel diagnostic marker of lung cancer.
- Br. J. Cancer 103, 217-222 (2010)
- PubMed
- Yoshimatsu, M., Toyokawa, G., Hayami, S., Unoki, M., Tsunoda, T., Field, H.I., Kelly, J.D., Neal, D.E., Maehara, Y., Ponder, B.A.J., Nakamura, Y. & Hamamoto R..
- Dysregulation of PRMT1 and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers.
- Int. J. Can.128, 562-573 (2011)
- PubMed
- Hayami, S., Kelly, J.D., Cho, H.S., Yoshimatsu, M., Unoki, M., Tsunoda, T., Field, H.I., Neal, D.E., Yamaue, H., Ponder, B.A.J., Nakamura, Y. & Hamamoto, R.
- Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers.
- Int. J. Can.128, 574-586 (2011)
- PubMed
- Hayami, S., Yoshimatsu, M., Veerakumarasivam, A., Unoki, M., Iwai, Y., Tsunoda, T., Field, H.I., Kelly, J.D., Neal, D.E., Yamaue, H., Ponder, B.A.J., Nakamura, Y. & Hamamoto, R.
- Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.
- Mol. Cancer.9, 59 (2010)
- PubMed
- Unoki, M., Kelly, J.D., Neal, D.E., Ponder, B.A., Nakamura, Y. & Hamamoto, R.
- UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer.
- Br. J. Cancer. 101, 98-105 (2009)
- PubMed
- Kumamoto, K., Fujita, K., Kurotani, R., Saito, M., Unoki, M., Hagiwara, N., Shiga, H., Bowman, E.D., Yanaihara, N., Okamura, S., Nagashima, M., Miyamoto, K., Takenoshita, S., Yokota, J. & Harris C.C.
- ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.
- Int. J. Can. 125, 1306-1315 (2009)
- PubMed
- Unoki, M., Kumamoto, K., Robles, A.I., Shen, J.C., Zheng, Z.M. & Harris, C.C.
- A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.
- FEBS. Lett.582, 3868-3874 (2008)
- PubMed
- Unoki, M., Bronner, C. & Mousli, M.
- A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1.
- Radiat. Res. 169, 240-244 (2008)
- PubMed
- Brunet, J., Pfaff, A.W., Abidi, A., Unoki, M., Nakamura, Y., Guinard, M., Klein, J.P., Candolfi, E. & Mousli, M.
- Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation.
- Cell. Microbiol. 10, 908-920 (2008)
- PubMed
- Shen, J.C., Unoki, M., Ythier, D., Duperray, A., Varticovski, L., Kumamoto, K., Pedeux, R. & Harris, C.C.
- Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1.
- Cancer. Res. 67, 2552-2558 (2007)
- PubMed
- Unoki, M., Shen, J.C., Zheng, Z.M. & Harris, C.C.
- Novel splice variants of ING4 and their possible roles in regulation of cell growth and motility.
- J. Biol. Chem. 281, 34677-34686 (2006)
- PubMed
- Unoki, M., Nishidate, T. & Nakamura, Y.
- ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.
- Oncogene 23, 7601-7610 (2004)
- PubMed
- Unoki, M. & Nakamura Y.
- Methylation at CpG-islands in intron1 of EGR2 confers enhancer-like activity.
- FEBS. Lett. 554, 67-72 (2003)
- PubMed
- Unoki, M. & Nakamura Y.
- EGR2 induces apoptosis in various cancer-cell lines by direct transactivation of BNIP3L and BAK.
- Oncogene 22, 2172-2185 (2003)
- PubMed
- Unoki, M., Okutsu, J. & Nakamura Y.
- Identification of ZFP91 gene involved in acute myelogenous leukemia.
- Int. J. Oncol. 22, 1217-1224 (2003)
- PubMed
- Unoki, M. & Nakamura Y.
- Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.
- Oncogene 20, 4457-4465 (2001)
- PubMed
- Suzuki, C., Unoki M. & Nakamura Y.
- Identification and allelic frequencies of novel single-nucleotide polymorphisms in the DUSP1 and BTG1 genes.
- J. Hum. Genet. 46, 155-157 (2001)
- PubMed
- Matsushima-Nishiu, M., Unoki, M., Ono, K., Tsunoda, T., Minaguchi, T., Kuramoto, H., Nishida, M., Satoh, T., Tanaka, T. & Nakamura Y.
- Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.
- Cancer Res. 61, 3741-3749 (2001)
- PubMed
- Takeoka, S., Unoki, M., Onouchi, Y., Doi, S., Fujiwara, H., Miyatake, A., Fujita, K., Inoue, I., Nakamura, Y. & Tamari, M.
- Amino-acid substitutions in the IKAP gene product significantly increase risk for bronchial asthma in children.
- J. Hum. Genet. 46, 57-63 (2001)
- PubMed
- Yamada, R., Tanaka, T., Unoki, M., Nagai, T., Sawada, T., Ohnishi, Y., Tsunoda, T., Yukioka, M., Maeda, A., Suzuki, K., Tateishi, H., Ochi, T., Nakamura, Y. & Yamamoto, K.
- Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease.
- Am. J. Hum. Genet. 68, 674-685 (2001)
- PubMed
- Unoki, M., Furuta, S., Onouchi, Y., Watanabe, O., Doi, S., Fujiwara, H., Miyatake, A., Fujita, K., Tamari, M. & Nakamura, Y.
- Association studies of 33 single nucleotide polymorphisms (SNPs) in 29 candidate genes for bronchial asthma: positive association a T924C polymorphism in the thromboxane A2 receptor gene.
- Hum. Genet. 106, 440-446 (2000)
- PubMed
Publication List Page Top
Reviews
- Unoki, M. & Sasaki, H.
- The UHRF protein family in epigenetics, development, and carcinogenesis.
- Proc. Japan Acad. Ser. B 98, 401-415 (2022).
- Pubmed
- Unoki, M.
- Chromatin remodeling in replication-uncoupled maintenance DNA methylation and chromosome stability: Insights from ICF syndrome studies.
- Genes Cells 26, 349-359 (2021)
- PubMed
- Mori, T., Ikeda, D.D., Yamaguchi, Y., Unoki, M., NIRF Project.
- NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape.
- FEBS Lett. 586, 1570-1583 (2012)
- PubMed
- Unoki, M.
- Current and potential anticancer drugs targeting members of the UHRF1 complex including epigenetic modifiers.
- Recent Pat. Anticancer Drug Discov. 6, 116-130 (2011)
- PubMed
- Unoki, M., Brunet, J. & Mousli M.
- Drug discovery targeting epigenetic codes: the great potential of UHRF1, which links DNA methylation and histone modifications, as a drug target in cancers and toxoplasmosis.
- Biochem. Pharmacol. 78, 1279-1288 (2009)
- PubMed
- Unoki, M., Kumamoto, K. & Harris, C.C.
- ING proteins as potential anticancer drug targets.
- Curr. Drug Targets 10, 442-454 (2009)
- PubMed
- Unoki, M., Kumamoto, K., Takenoshita, S. & Harris, C.C.
- Reviewing the current classification of inhibitor of growth family proteins.
- Cancer Sci. 100, 1173-1179 (2009)
- PubMed
Books
- Unoki, M.
- Recent Insights into the Mechanisms of De Novo and Maintenance of DNA Methylation in Mammals.
- DNA methylation mechanism, InTech (2019)
- Unoki, M. & Sasaki, H.
- ICF syndrome.
- Encyclopedia of Cancer 1-5, Springer Berlin Heidelberg (2015)
- Unoki, M.
- UHRF1 is a potential molecular marker for diagnosis and prognosis of bladder cancer.
- Bladder Cancer 129-146, InTech (2012)
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