九州大学・エピゲノムネットワーク研究センター

研究内容

エピゲノムは人体を構成する個々の細胞が持つDNAやクロマチン蛋白質の化学修飾（メチル化やアセチル化等）の総体であり、これが細胞の種類に特異的な遺伝子発現を制御する。即ち、ゲノムをコンピューターのハードウェアに例えるなら、エピゲノムはそれを使いこなすソフトウェアである。このエピゲノムに破綻が生じるとがんをはじめとする病気を生じ、人為的に操作を加えるとiPS細胞やクローン動物を作ることができる。

本センターでは、超高速DNAシーケンサーを用いた最先端技術を駆使して、発生、疾患等の過程におけるエピゲノム変化を網羅的に解析するパイプラインを確立し（インフォーマティクスを含む）、学内外の共同利用・共同研究に供すると共に、DNAメチル化、ヒストン修飾、小分子RNA、クロマチン構造・立体配置等から成るエピゲノム制御ネットワークの解明を目指す。さらに、このネットワークの破綻ががんや生活習慣病などの病気を引き起こす過程を理解し、人為的に修復・改変する方法を探り、がん治療、再生医療、創薬等に生かす。

エピゲノム制御研究部門: 基本的なエピゲノム制御のネットワークを研究する
細胞機能制御研究部門: 正常と疾患の細胞機能制御ネットワークを研究する
発生・分化制御研究部門: 発生・分化における制御ネットワークを研究する
エピゲノミクス研究部門: エピゲノミクス技術の開発と医学・生物学への応用を行う

研究成果

原著論文　 Original Research Papers

Sakata, Y., Nagao, K., Hoki, Y., Sasaki, H., Obuse, C. & Sado, T.: Defects in dosage compensation impact global gene regulation in the mouse trophoblast.; Development 144, 2784-2797 (2017); PubMed

Fukuda, K., Inoguchi, Y., Ichiyanagi, K., Ichiyanagi, T., Go, Y., Nagano, M., Yanagawa, Y., Takaesu, N., Ohkawa, Y., Imai, H. & Sasaki, H.: Evolution of the sperm methylome of primates is associated with retrotransposon insertions and genome instability.; Hum. Mol. Genet. 26, 3508-3519 (2017); PubMed

Ohta, H., Kurimoto, K., Okamoto, I., Nakamura, T., Yabuta, Y., Miyauchi, H., Yamamoto, T., Okuno, Y., Hagiwara, M., Shirane, K., Sasaki, H. & Saitou, M.: In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.; EMBO J. 36, 1888-1907 (2017); PubMed

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Ueda, J., Harada, A., Urahama, T., Machida, S., Maehara, K., Hada, M., Makino, Y., Nogami, J., Horikoshi, N., Osakabe, A., Taguchi, H., Tanaka, H., Tachiwana, H., Yao, T., Yamada, M., Iwamoto, T., Isotani, A., Ikawa, M., Tachibana, T., Okada, Y., Kimura, H., Ohkawa, Y., Kurumizaka, H. & Yamagata, K.: Testis-specific histone variant H3t gene is essential for entry into spermatogenesis.; Cell Rep. 112, 18, 593-600 (2017); PubMed

Kabayama, Y., Toh, H., Katanaya, A., Sakurai, T., Chuma, S., Kuramochi-Miyagawa, S., Saga, Y., Nakano, T. & Sasaki, H.: Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes.; Nucl. Acids Res. 45, 5387-5398 (2017); PubMed

Toh, H., Shirane, K., Miura, F., Kubo, N., Ichiyanagi, K., Hayashi, K., Saitou, M., Suyama, M., Ito, T. & Sasaki, H.: Software updates in the Illumina HiSeq platform affect whole-genome bisulfite sequencing.; BMC Genomics 18, 31 (2017); PubMed

Kobayashi, M., Kato, H., Hada, H., Itoh-Nakadai, A., Fujiwara, T., Muto, A., Inoguch, Y., Ichiyanagi, K., Houjou, W., Tomosugi, N., Sasaki, H., Harigae, H., & Igarashi, K.: Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency.; Haematologica 102, 454-465 (2017); PubMed

Ishikura, Y., Yabuta, Y., Ohta, H., Hayashi, K., Nakamura, T., Okamoto, I., Yamamoto, T., Kurimoto, K., Shirane, K., Sasaki, H. & Saitou, M.: In vitro derivation and propagation of spermatogonial stem cell activity from mouse pluripotent stem cells.; Cell Rep. 17, 2789-2804 (2016); PubMed

Hamada, H., Okae, H., Toh, H., Chiba, H., Hiura, H., Shirane, K., Sato, T., Suyama, M., Yaegashi, N., Sasaki, H. & Arima, T.: Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placenta.; Am. J. Hum. Genet. 99, 1045-1058 (2016); PubMed

Shirane, K., Kurimoto, K., Yabuta, Y., Yamaji, M., Satoh, J., Ito, S., Watanabe, A., Hayashi, K., Saitou, M. & Sasaki, H.: Global landscape and regulatory principles of DNA methylation reprogramming for germ cell specification by mouse pluripotent stem cells.; Dev. Cell 39, 87-103 (2016); PubMed

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T. & Nakayama, K. I.: CHD8 haploinsufficiency results in autistic-like phenotypes in mice.; Nature. 537, 675-679 (2016); PubMed

Kaimori, JY., Maehara, K., Hayashi-Takanaka, Y., Harada, A., Fukuda, M., Yamamoto, S., Ichimaru, N., Umehara, T., Yokoyama, S., Matsuda, R., Ikura, T., Nagao, K., Obuse, C., Nozaki, N., Takahara, S., Takao, T., Ohkawa, Y., Kimura, H. & Isaka, Y.: Histone H4 lysine 20 acetylation is associated with gene repression in human cells.; Sci Rep. 6, 24318 (2016); PubMed

Kobayashi, W., Takaku, M., Machida, S., Tachiwana, H., Maehara, K., Ohkawa, Y. & Kurumizaka, H.: Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing.; Sci. Rep. 6, 24228 (2016); PubMed

Hatanaka, Y., Inoue., K, Oikawa, M., Kamimura, S., Ogonuki, N., Kodama, E. N., Ohkawa, Y., Tsukada, Y. & Ogura, A.: Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation embryos from endogenous retrotransposons.; Proc. Natl. Acad. Sci. USA 112, 14641-14646 (2015); PubMed

Tsukada, Y., Akiyama, T. & Nakayama, K. I.: Maternal TET3 is dispensable for embryonic development but is required for neonatal growth.; Sci. Rep. 5, 15876 (2015); PubMed

Maehara, K., Harada, A., Sato, Y., Matsumoto, M., Nakayama, K. I., Kimura, H. & Ohkawa, Y.: Tissue-specific expression of histone H3 variants diversified after species separation.; Epigenet. Chromatin 8, 35 (2015); PubMed

Kubo, N., Toh, H., Shirane, K., Shirakawa, T., Kobayashi, H., Sato, T., Sone, H., Sato, Y., Tomizawa, S., Tsurusaki, Y., Shibata, H., Saitsu, H., Suzuki, Y., Matumoto, N., Suyama, M., Kono, T., Ohba, K. & Sasaki, H.: DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.; BMC Genomics 16, 624 (2015); PubMed

Sano, K., Miura, S., Fujiwara, T., Fujioka, R., Yorita, A., Noda, K., Kida, H., Azuma, K., Kaieda, S., Yamamoto, K., Taniwaki, T., Fukumaki, Y. & Shibata, H.: A novel missense mutation of RYR1 in familial idiopathic hyper CK-emia.; J. Neurol. Sci. 356, 142-147 (2015); PubMed

Thijssen, P.E., Ito, Y., Grillo, G., Wang, J., Velasco, G., Nitta, H., Unoki, M., Yoshihara, M., Suyama, M., Sun, Y., Lemmers, R.J.L.F., de Greef, J.C., Gennery, A., Picco, P., Kloeckener-Gruissem, B., Gungor, T., Reisli, I., Picard, C., Kebaili, K., Roquelaure, B., Iwai, T., Kondo, I., Kubota, T., van Ostaijen-Ten Dam, M.M., van Tol, M.J.D., Weemaes, C., Francastel, C., van der Maarel, S.M. & Sasaki. H.: Mutations in CDCA7 and HELLS cause immunodeficiency-centromeric instability-facial anomalies syndrome.; Nat. Commun. 6, 7870 (2015); PubMed

Kawaguchi, T., Tanigawa, A., Naganuma, T., Ohkawa, Y., Souquere, S., Pierron, G. & Hirose, T.: SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies.; Proc. Natl. Acad. Sci. USA 112, 4304-4309 (2015); PubMed

Harada, A., Mallappa, C., Okada, S., Butler, JT., Baker, SP., Lawrence, JB., Ohkawa, Y. & Imbalzano, AN.: Spatial re-organization of myogenic regulatory sequences temporally controls gene expression.; Nucleic Acids Res. 43, 2008-21(2015); PubMed

Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Nakayama, KI., Matusik, R. & Chen, Z.: SKP2 inactivation suppresses prostate tumorigenesis by enhancing JARID1B ubiquitination for H3K4me3 reduction.; Oncotarget 6, 771-788 (2015); PubMed

Nakamura, M., Shibata, K., Hatano, S., Sato, T., Ohkawa, Y., Yamada, H., Ikuta, K. & Yoshikai, Y.: A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.; J. Immunol. 194, 243-251 (2015); PubMed

Harada, A., Maehara, K., Sato, Y., Konno, D., Tachibana, T., Kimura, H. & Ohkawa, Y.: Incorporation of histone H3.1 suppresses the lineage potential of skeletal muscle.; Nucleic Acids Res. 43, 775-786 (2015); PubMed

Takahashi, H., Takigawa, I., Watanabe, M., Anwar, D., Shibata, M., Tomomori-Sato, C., Sato, S., Ranjan, A., Seidel, C.W., Tsukiyama, T., Mizushima, W., Hayashi, M., Ohkawa, Y., Conaway, J.W., Conaway, R.C. & Hatakeyama, S.: MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.; Nat. Commun. 6, 5941 (2015); PubMed

Yamaguchi, K., Chijiwa, T., Ikeda, N., Shibata, H., Fukumaki, Y., Oda-Ueda, N., Hattori, S. & Ohno, M.: The finding of a group IIE phospholipase A2 gene in a specified segment of Protobothrops flavoviridis genome and its possible evolutionary relationship to group IIA phospholipase A2 genes.; Toxins 6, 3471-3487 (2014); PubMed

Stasevich, T.J., Hayashi-Takanaka, Y., Sato, Y., Maehara, K., Ohkawa, Y., Sakata-Sogawa, K., Tokunaga, M., Nagase, T., Nozaki, N., McNally, J.G. & Kimura, H.: Regulation of RNA polymerase II activation by histone acetylation in single living cells.; Nature 516, 272-275 (2014); PubMed

Oki, S., Maehara, K., Ohkawa, Y. & Meno, C.: SraTailor: graphical user interface software for processing and visualizing ChIP-seq data.; Genes Cells 12, 919-926 (2014); PubMed

Matsumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nutt, S.L., Sakaguchi, S., Takeda, K., Kurosaki, T. & Baba, Y.: Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation.; Immunity 41, 1040-1051 (2014); PubMed

Ichiyanagi, T., Ichiyanagi, K., Ogawa, A., Kuramochi-Miyagawa, S., Nakano, T., Chuma, S., Sasaki, H. & Udono, H.: HSP90α plays an important role in piRNA biogenesis and retrotransposon repression in mouse.; Nucl. Acids Res. 42, 11903-11911 (2014); PubMed

Kobayakawa, K., Kumamaru, H., Saiwai, H., Kubota, K., Ohkawa, Y., Kishimoto, J., Yokota, K., Ideta, R., Shiba, K., Tozaki-Saitoh, H., Inoue, K., Iwamoto, Y. & Okada, S.: Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans.; Sci. Transl. Med. 6, 256ra137 (2014); PubMed

Tamura, I., Ohkawa, Y., Sato, T., Suyama, M., Jozaki, K., Okada, M., Lee, L., Maekawa, R., Asada, H., Sato, S., Yamagata, Y., Tamura, H. & Sugino, N.: Genome-wide analysis of histone modifications in human endometrial stromal cells.; Mol Endocrinol. 28, 1656-1669 (2014); PubMed

Liu, S., Brind’Amour, J., Karimi, M.M., Shirane, K., Bogutz, A., Lefebvre, L., Sasaki, H., Shinkai, Y. & Lorincz, M.C.: Setdb1 is required for germ line development and silencing of H3K9me3 marked endogenous retroviruses in primordial germ cells.; Genes Dev. 28, 2041-2055 (2014); PubMed

Yamauchi, T., Nishiyama, M., Moroishi, T., Yumimoto, K. & Nakayama, KI.: MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-box RNA helicase DDX24.; Mol. Cell. Biol. 34, 3321-3340 (2014); PubMed

Yokoyama, A., Igarashi, K., Sato, T., Takagi, K., Otsuka, I. M., Shishido, Y., Baba, T., Ito, R., Kanno, J., Ohkawa, Y., Morohashi, K. & Sugawara, A.: Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.; J. Biol. Chem. 289, 18152-1862 (2014); PubMed

Ueda, J., Maehara, K., Mashiko, D., Ichinose, T., Yao, T., Hori, M., Sato, Y., Kimura, H., Ohkawa, Y. & Yamagata, K.: Heterochromatin dynamics during the differentiation process revealed by the DNA methylation reporter mouse, MethylRO.; Stem Cell Reports. 2, 910-924 (2014); PubMed

Yokomizo, H., Inoguchi, T., Sonoda, N., Sakaki, Y., Maeda, Y., Inoue, T., Hirata, E., Takei, R., Ikeda, N., Fujii, M., Fukuda, K., Sasaki, H. & Takayanagi, R.: Maternal high fat diet induces insulin resistance and deterioration of pancreatic β cell function in adult offspring with gender differences in mice.; Am. J. Physiol. Endocrinol. Metab. 306, E1163-1175 (2014); PubMed

Shiura, H., Okamoto, A., Sasaki, H. & Abe, K.: Whole-mount MeFISH: a novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression.; PLoS One 9, e95750 (2014); PubMed

Velasco, G., Walton, L. E., Sterlin, D., Hedouin, S., Nitta, H., Ito, Y., Fouyssac F., Megarbane, A., Sasaki, H., Picard, C. & Francastel, C.: Germline genes hypomethylation and expression define a molecular signature in peripheral blood of ICF patients: implications for diagnosis and etiology.; Orphanet J. Rare Dis. 9, 56 (2014); PubMed

Baba, T., Otake, H., Sato, T., Miyabayashi, K., Shishido, Y., Wang, CY., Shima, Y., Kimura, H., Yagi, M., Ishihara, Y., Hino, S., Ogawa, H., Nakao, M., Yamazaki, T., Kang, D., Ohkawa, Y., Suyama, M., Chung, BC. & Morohashi, K.: Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1..; Nat. Commun. 5, 3634 (2014); PubMed

Matsumoto, A., Takeishi, S. & Nakayama, KI.: p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling.; Blood 123, 3429-3439 (2014); PubMed

Lu, Z., Bauzon, F., Fu, H., Cui, J., Zhao, H., Nakayama, K., Nakayama, KI. & Zhu, L.: Skp2 suppresses apoptosis in Rb1 deficient tumors by limiting E2F1 activity.; Nature Commun. 5, 3463 (2014); PubMed

Okae, H., Matoba, S. Nagashima, T., Mizutani, E., Inoue, K., Ogonuki, N., Chiba, H., Funayama, R., Tanaka, S., Yaegashi, N., Nakayama, K., Sasaki, H., Ogura, A. & Arima, T.: RNA sequencing-based identification of aberrant imprinting in cloned mice.; Hum. Mol. Genet. 23, 992-1001 (2014); PubMed

Harada, A.., Okazaki, E., Okada, S., Tachibana, T. & Ohkawa, Y.: Production of a monoclonal antibody for C/EBPβ: the subnuclear localization of C/EBPβ in mouse L929 cells.; Monoclon Antib Immunodiagn Immunother 33, 34-37 (2014); PubMed

Harada, A., Hayashi, M., Kuniyoshi, Y., Semba, Y., Sugahara, S., Tachibana, T., Ohkawa, Y. & Fujita, M.: Generation of a monoclonal antibody for INI1/hSNF5/BAF47.; Monoclon Antib Immunodiagn Immunother 33, 49-51 (2014); PubMed

LeBlanc, SE., Wu, Q., Barutcu, AR., Xiao, H., Ohkawa, Y. & Imbalzano, AN.: The PPARγ locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner.; PLoS One. 9, e86140 (2014); PubMed

Katahira, J., Okuzaki, D., Inoue, H., Yoneda, Y., Maehara, K. & Ohkawa, Y.: Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I.; Nucleic Acids Res. 41, 7060-7072 (2013); PubMed

Kumamaru, H., Saiwai, H., Kubota, K., Kobayakawa, K., Yokota, K., Ohkawa, Y. Shiba, K., Iwamoto, Y. & Okada, S.: Therapeutic activities of engrafted neural stem/precursor cells are not dormant in the chronically injured spinal cord.; Stem Cells 31, 1535-1547 (2013); PubMed

Yoshimi, T., Ohkawa, Y., Azuma, M. & Tachibana, T.: A panel of specific monoclonal antibodies directed against various phosphorylated histones H3.; Monoclon Antib Immunodiagn Immunother 32, 119-124 (2014); PubMed

Nitta, H., Unoki, M., Ichiyanagi, K., Kosho, T., Shigemura, T., Takahashi, H., Velasco, G., Francastel, C., Picard, C., Kubota, T. & Sasaki, H.: Three novel ZBTB24 mutations identified in Japanese and Cape Verdean type 2 ICF syndrome patients.; J. Hum. Genet. 58, 455-460 (2013); PubMed

Fukuda, K., Ichiyanagi, K., Yamada, Y., Go, Y., Udono, T., Wada, S., Maeda, T., Soejima, H., Saitou, N., Ito, T. & Sasaki, H.: Regional DNA methylation differences between humans and chimpanzees are associated with genetic changes, transcriptional divergence and disease genes.; J. Hum. Genet. 58, 446-454 (2013); PubMed

Shirane, K., Toh, H., Kobayashi, H., Miura, F., Chiba, H., Ito, T., Kono, T. & Sasaki, H.: Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases.; PLoS Genet. 9, e1003439 (2013); PubMed

Unoki, M., Masuda, A., Dohmae, N., Arita, K., Yoshimatsu, M., Iwai, Y., Fukui, Y., Ueda, K., Hamamoto, R., Shirakawa, M., Sasaki, H. & Nakamura, Y.: Lysyl 5-Hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6).; J. Biol. Chem. 288, 6053-6062 (2013); PubMed

Yamamoto, Y., Watanabe, T., Hoki, Y., Shirane, K., Li, Y., Ichiyanagi, K., Kuramochi-Miyagawa, S., Toyoda, A., Fujiyama, A., Oginuma, M., Suzuki, H., Sado, T., Nakano, T. & Sasaki, H.: Targeted gene silencing in mouse germ cells by insertion of a homologous DNA into a piRNA generating locus.; Genome Res. 23, 292-299 (2013); PubMed

Ichiyanagi, T., Ichiyanagi, K., Miyake, M. & Sasaki, H.: Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development.; Nucl. Acids Res. 41, 738-745 (2013); PubMed

Sekiya, S., Suzuki, A.: Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes.; J. Clin. Invest. 122, 3914-3918 (2012); PubMed

Nishiyama, M., Skoultchi, AI. & Nakayama, KI.: Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-beta-catenin signaling pathway.; Mol. Cell. Biol. 32, 501-12 (2012); PubMed

Kita Y., Nishiyama M., Nakayama KI.: Identification of CHD7S as a novel splicing variant of CHD7 with functions similar and antagonistic to those of the full-length CHD7L; Genes Cells 17, 536-547 (2012); PubMed

Okita, Y., Matsumoto, A., Yumimoto, K., Isoshita, R. & Nakayama, KI.: Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation.; Genes Cells 17, 768-777 (2012); PubMed

Harada, A., Okada, S., Konno, D., Odawara, J., Yoshimi, T., Yoshimura, S., Kumamaru, H., Saiwai, H., Tsubota, T., Kurumizaka, H., Akashi, K., Tachibana, T., Imbalzano, A.N., & Ohkawa, Y.: Chd2 interacts with H3.3 to determine myogenic cell fate.; EMBO J. 31, 2994-3007 (2012); PubMed

Kofunato Y., Kumamoto K., Saitou K., Hayase S., Okayama H., Miyamoto K., Sato Y., Katakura K., Nakamura I., Ohki S., Koyama Y., Unoki M., Takenoshita S.: UHRF1 expression is upregulated and associated with cellular proliferation in colorectal cancer.; Oncol. Rep. 28, 1997-2002 (2012); PubMed

Liu, Y., Toh, H., Sasaki, H., Zhang, X. & Cheng, X.: An atomic model of ZFP57 recognition of CpG methylation within a specific DNA sequence.; Genes Dev. 26, 2374-2379 (2012); PubMed

Arita K., Isogai S., Oda T., Unoki M., Sugita K., Sekiyama N., Kuwata K., Hamamoto R., Tochio H., Sato M., Ariyoshi M., Shirakawa M.: Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.; Proc. Natl. Acad. Sci. USA 109, 12950-12955 (2012); PubMed

Takahashi, T., Matsuzaki, H., Tomizawa, S., Okamura, E., Ichiyanagi, T., Fukamizu, A., Sasaki, H. & Tanimoto, K.: Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice.; Gene 508, 26-34 (2012); PubMed

Ichiyanagi, K.: Inhibition of MspI cleavage activity by hydroxymethylation of the CpG site: A concern for DNA modification studies using restriction endonucleases.; Epigenetics 7,131-136 (2012); PubMed

Ohnishi, Y., Totoki, Y., Toyoda, A., Watanabe, T., Yamamoto, Y., Tokunaga, K., Sakaki, Y., Sasaki, H. & Hohjoh, H.: Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development.; Mol. Biol. Rep. 39, 903-909 (2012); PubMed

Okae, H., Hiura, H., Miyauchi, N., Abe, C., Nishida, Y., Funayama, R., Tanaka, S., Chiba, H., Yaegashi, N., Nakayama, K., Sasaki, H. & Arima, T.: Re-investigation and RNA sequencing-based identification of genes with placenta-specific imprinted expression.; Hum. Mol. Genet. 21, 548-558 (2012); PubMed

Ichiyanagi, K., Li, Y., Watanabe, T., Ichiyanagi, T., Fukuda, K., Kitayama, J., Yamamoto, Y., Kuramochi-Miyagawa, S., Nakano, T., Yabuta, Y., Seki, Y., Saitou, M., & Sasaki, H.: Locus- and domain-dependent control of DNA methylation at mouse B1 retrotransposons during male germ cell development.; Genome Res. 21, 2058-2066 (2011); PubMed

Odawara, J., Harada, A., Yoshimi, T., Maehara, K., Tachibana, T., Okada, S., Akashi, K. & Ohkawa, Y.: The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach; BMC Genomics 12, 516 (2011); PubMed

Hoki, Y., Ikeda, R., Mise, N., Sakata, Y., Ohhata, T., Sasaki, H., Abe, K., & Sado, T.: Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse; Development 138, 2649-59 (2011); PubMed

Sekiya, S. & Suzuki A.: Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors; Nature 475, 390-393 (2011); Pubmed

Watanabe, T., Tomizawa, S., Mitsuya, K., Totoki, Y., Yamamoto, Y., Kuramochi-Miyagawa, S., Iida, N., Hoki, Y., Murphy, P.J., Toyoda, A., Gotoh, K., Hiura, H., Arima, T., Fujiyama, A., Sado, T., Shibata, T., Nakano, T., Lin, H., Ichiyanagi, K., Soloway, P.D. & Sasaki, H.: Role for piRNAs and non-coding RNA in de novo DNA methylation of the imprinted mouse Rasgrf1 locus.; Science 332, 848-852 (2011); Pubmed

総説　 Reviews

Sado, T. & Brockdorff, N.: Advances in understanding chromosome silencing by the long non-coding RNA Xist.; Philos. Trans. R. Soc. Lond. B. Biol. Sci. 368, 20110325 (2013); PubMed

Ichiyanagi, K.: Epigenetic regulation of transcription and possible functions of mammalian short interspersed elements, SINEs.; Genes Genet. Syst. 88, 19-29 (2013); PubMed

Ichiyanagi, K.: Transposable elements in eukaryotic genomes: epigenetic regulation by the host and functionalization for the host.; Genes Genet. Syst. 88, 1 (2013); PubMed

Okita, Y. & Nakayama, KI.: UPS delivers pluripotency.; Cell Stem Cell 11, 728-730 (2012); PubMed

Mori T., Ikeda D.D., Yamaguchi Y., Unoki M., NIRF Project.: NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape.; FEBS Lett. 586, 1570-1583 (2012); PubMed

Tomizawa, S. & Sasaki, H.: Genomic imprinting and its relevance to congenital disease, infertility, molar pregnancy and induced pluripotent stem cells; J. Hum. Genet. 57, 84-91 (2012); PubMed

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